|
Parameter
|
Intervention (n = 1918)
|
Control (n = 1952)
|
|---|
|
Age, years
|
55.7 (3.2) [n = 1919]
|
56.1 (5.3) [n = 1952]
|
|
Women, No (%)
|
732 (38) [n = 1918]
|
750 (38) [n = 1952]
|
|
PaO2/FIO2 at enrolment, mmHg
|
135.8 (14.4) [n = 1859]
|
134.7 (17.4) [n = 1892]
|
|
Respiratory system compliance, mL/cmH2O
|
32.9 (5.1) [n = 969]
|
32.0 (4.4) [n = 975]
|
|
Causes of lung injury
| | |
|
Pneumonia, No. (%)
|
920 (49) [n = 1878]
|
933 (49) [n = 1911]
|
|
Aspiration, No. (%)
|
175 (13) [n = 1373]
|
185 (13) [n = 1376]
|
|
Sepsis, No. (%)
|
495 (26) [n = 1908]
|
538 (28) [n = 1942]
|
|
Multiple trauma, No. (%)
|
54 (4) [n = 1394]
|
72 (5) [n = 1432]
|
|
Ventilation parameters
| | |
|
Tidal volume, mL/kg of predicted body weight
|
7.3 (1.1) [n = 1909]
|
7.4 (1.2) [n = 1942]
|
|
Set PEEP, cmH2O
|
11.2 (1.8) [n = 1643]
|
11.1 (2.1) [n = 1679]
|
|
Driving pressure, cmH2O
|
15.4 (2.4) [n = 1575]
|
15.2 (2.1) [n = 1615]
|
|
Plateau pressure, cmH2O
|
27.0 (2.8) [n = 1575]
|
26.8 (2.7) [n = 1615]
|
- Data are mean (standard deviation) or frequency (proportion). Number of patients for each variable is also reported, as data was missing or not reported as mean in all studies. Values are estimated means (standard deviations) calculated with a mixed-effects model using the DerSimonian-Laird method. PEEP positive end-expiratory pressure
