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Table 1 Overview of various sulfide donors and their sulfide release

From: H2S in acute lung injury: a therapeutic dead end(?)

Donor category Compounds Sulfide release
Inhalation Gaseous H2S Rapid, high risk of toxic peak concentrations
Sulfide-releasing salts Na2S, NaHS, IK-1001 Rapid, high risk of toxic peak concentrations
Slow-releasing donors GYY4137, AP39, DATS, SG-1002 Slow, toxicity ultimately not clear
Clinically available compounds Sodium thiosulfate (STS), Ammonium tetrathiomolybdate (ATTM), Zofenopril Slow, good safety profile