Table 1 Overview of various sulfide donors and their sulfide release
Donor category | Compounds | Sulfide release |
|---|---|---|
Inhalation | Gaseous H2S | Rapid, high risk of toxic peak concentrations |
Sulfide-releasing salts | Na2S, NaHS, IK-1001 | Rapid, high risk of toxic peak concentrations |
Slow-releasing donors | GYY4137, AP39, DATS, SG-1002 | Slow, toxicity ultimately not clear |
Clinically available compounds | Sodium thiosulfate (STS), Ammonium tetrathiomolybdate (ATTM), Zofenopril | Slow, good safety profile |