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Table 2 Lung function in a resuscitated comorbid porcine model of hemorrhagic shock [122]

From: H2S in acute lung injury: a therapeutic dead end(?)

Timepoint Group assignment Horowitz index (mmHg) PEEP (cmH2O)
Baseline Control 400 (338, 448) 0
Thiosulfate 351 (328, 427) 0
After shock (start of STS infusion) Control 376 (322, 431) 0
Thiosulfate 352 (283, 405) 0
24 h after shock (end of STS infusion) Control 387 (326, 418) 10 (10, 10)
Thiosulfate 385 (355, 417) 10 (10, 10)
48 h after shock Control 230 (195, 270)# 12.5 (12.5, 15)
Thiosulfate 299 (263, 339)* 11.3 (10, 12.5)
72 h after shock Control 289 (106, 323)# 15 (12.5, 15)
Thiosulfate 337 (300, 387) 10 (10, 12.5)*
  1. Atherosclerotic pigs were surgically instrumented and, after a short recovery period, underwent 3 h of hemorrhagic shock (target mean arterial pressure 40 ± 5 mmHg). Seventy-two hours of resuscitation comprised re-transfusion of the shed blood and fluid and catecholamine administration targeted to the pre-shock mean arterial pressure. Further details about the experimental protocol can be found in [122]. STS was administered during the first 24 h of resuscitation after hemorrhagic shock. Effects on lung function were most pronounced at 48 h after hemorrhagic shock. Data shown are median (lower quartile, upper quartile)
  2. *Significant to control group
  3. #Significant to baseline (p < 0.05 in two-way ANOVA)