TY - JOUR AU - Wirtz, Mathijs R. AU - van den Brink, Daan P. AU - Roelofs, Joris J. T. H. AU - Goslings, J. Carel AU - Juffermans, Nicole P. PY - 2020 DA - 2020/12/18 TI - Therapeutic application of recombinant human ADAMTS-13 improves shock reversal and coagulation status in a trauma hemorrhage and transfusion rat model JO - Intensive Care Medicine Experimental SP - 42 VL - 8 IS - 1 AB - In hemorrhaging trauma patients, the endothelium is activated, resulting in excessive endothelial synthesis of von Willebrand Factor (vWF), which may enhance micro-thrombi formation, resulting in obstruction of the microcirculation and endothelial injury, aggravating bleeding, as well as contributing to organ failure. Under normal conditions, vWF is cleaved by the metalloprotease ADAMTS-13. After trauma, ADAMTS-13 levels are reduced. SN - 2197-425X UR - https://doi.org/10.1186/s40635-020-00328-w DO - 10.1186/s40635-020-00328-w ID - Wirtz2020 ER -