In vivo testing of the low-flow CO2 removal application of a compact, platform respiratory device

Intensive Care Medicine Experimental

Table 2 Hematologic and end organ function parameters

Parameter	Pre-Op	POD 0	POD 1^a	POD 3^b	POD 6^c	POD 7^d,e
PAF activated [%]	71 ± 9	70 ± 10	77 ± 11	72 ± 11	75 ± 12	76 ± 3
CD62P [%]	3 ± 1	4 ± 2	2 ± 1	5 ± 5	5 ± 3	4 ± 2
Platelet count [k/μL]	576 ± 252	397 ± 110	499 ± 186	703 ± 281	520 ± 115	552 ± 198
WBC [K/μL]	9 ± 3	7 ± 2	12 ± 4	11 ± 4	12 ± 5	12 ± 1.7^f
HCT [%]	36 ± 3	24 ± 2^f	29 ± 2^f	27 ± 6^f	24 ± 4^f	27 ± 7^f
Creatinine [mg/dL]	1 ± 0	1 ± 0	2 ± 1	3 ± 3	1 ± 0	1 ± 0
BUN [mg/dL]	11 ± 2	11 ± 3	11 ± 5	27 ± 21	26 ± 16^f	14 ± 4
CK [U/L]	103 ± 23	155 ± 51	143 ± 72	71 ± 11	149 ± 88	126 ± 80
ALT [U/L]	12 ± 5	9 ± 3	9 ± 4	5 ± 3	5 ± 2	5 ± 5
AST [U/L]	71 ± 14	58 ± 11	73 ± 19	56 ± 10	53 ± 12	59 ± 9
ALP [U/L]	218 ± 56	165 ± 55	158 ± 41	141 ± 33	101 ± 26	128 ± 64

ALT alanine transferase, ALP alkaline phosphatase, AST aspartate aminotransferase, BUN blood urea nitrogen, CK creatine kinase, HCT hematocrit, PAF platelet-activating factor, WBC white blood cell count
^aMissing platelet count from animal 6
^bMissing platelet count from animals 2, 5, and 6
^cMissing all data, except HCT, for animals 3, 4, and 6
^dMissing all data, except HCT, for animals 4 and 5
^eMissing CD62P and PAF activated for animal 3
^fStatistically significant compared to pre-op value (p < 0.05)