Table 1 Characteristics of the 99 donor lungs stratified by 6 experimental conditions.
From: The endogenous capacity to produce proinflammatory mediators by the ex vivo human perfused lung
With blood n=55 | Without Blood n=44 | P-value | |||||
|---|---|---|---|---|---|---|---|
Control lungs n=22 | IV bacteria n=19 | Airspace bacteria n=14 | Control lungs n=18 | IV bacteria n=23 | Airspace bacteria n=3 | ||
Donor age b | 44 (30, 55) | 45 (32, 54) | 45.5 (30, 55) | 40 (38, 46) | 53 (32, 64) | 59 (55, 69) | 0.4 |
Donor sex | 15 (68%) | 13 (68%) | 9 (64%) | 11 (61%) | 16 (70%) | 3 (100%) | 0.9 |
Donor weight (kg) b | 88.5 (83.1, 104.3) | 86.9 (72.7, 96) | 83.9 (66.5, 112) | 89.7 (75, 104) | 83 (73.4, 96) | 108 (85, 171) | 0.5 |
Donor height (cm) a | 172.5 (±14.5) | 174.4 (±7) | 172.1 (±8.8) | 173.7 (±10.8) | 169.9 (±10.6) | 179.3 (±4) | 0.5 |
Cold ischemia Time (h) a | 20 (±13.5) | 23.7 (±13.3) | 19.3 (±14) | 24.6 (±10.6) | 19.7 (±10) | 28 (±8.5) | 0.6 |
Pre-procurement antibiotics | 13 (59%) | 13 (68%) | 13 (93%) | 16 (89%) | 12 (52%) | 2 (67%) | 0.05 |
NDD | 19 (86%) | 18 (95%) | 13 (93%) | 17 (94%) | 20 (87%) | 3 (100%) | 0.9 |
Trauma | 6 (27%) | 5 (26%) | 4 (29%) | 5 (28%) | 8 (35%) | 2 (67%) | 0.8 |
CPR | 14 (64%) | 10 (53%) | 10 (71%) | 9 (50%) | 12 (52%) | 1 (33%) | 0.7 |
PaO2:FiO2 ratio a | 224 (±74) | 268 (±103) | 237 (±136) | 251 (±111) | 242 (±100) | 251 (±104) | 0.7 |
Normal baseline AFC | 17 (77%) | 15 (79%) | 11 (79%) | 16 (89%) | 20 (87%) | 2 (67%) | 0.9 |
AFC at baseline b | 33.4 (9.5, 45.5) | 27.3 (9.2, 40) | 18.4 (15.4, 32.2) | 28.8 (15, 33.3) | 28 (18.2, 38.9) | 20.6 (4.3, 49.1) | 0.9 |
AFC at 5h b | 14 (9.5, 36.2) | 18.7 (9.5, 29.7) | 2.7 (0, 16.9) | 22.7 (14.8, 32) | 15.2 (13.3, 32.4) | 5 (0, 10) | 0.02 |
Start lung weight (g) b | 402 (330, 532) | 383 (351, 438) | 372 (294, 396) | 365 (297, 406) | 360 (328, 414) | 555 (373, 562) | 0.2 |
End lung weight (g) b | 631 (564, 958) | 784 (720, 1232) | 767 (603, 891) | 722 (630, 774) | 779 (696, 987) | 1328 (1312, 1344) | 0.1 |
% weight gain b | 62 (44, 99) | 115 (69, 186) | 98 (83, 154) | 99 (80, 128) | 101 (82, 134) | 138 (133, 142) | 0.04 |