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Intensive Care Medicine Experimental

Table 1 Characteristics of the 99 donor lungs stratified by 6 experimental conditions.

From: The endogenous capacity to produce proinflammatory mediators by the ex vivo human perfused lung

 

With blood

n=55

Without Blood

n=44

P-value

Control lungs

n=22

IV bacteria

n=19

Airspace bacteria

n=14

Control lungs

n=18

IV bacteria

n=23

Airspace bacteria

n=3

Donor age b

44 (30, 55)

45 (32, 54)

45.5 (30, 55)

40 (38, 46)

53 (32, 64)

59 (55, 69)

0.4

Donor sex

15 (68%)

13 (68%)

9 (64%)

11 (61%)

16 (70%)

3 (100%)

0.9

Donor weight (kg) b

88.5 (83.1, 104.3)

86.9 (72.7, 96)

83.9 (66.5, 112)

89.7 (75, 104)

83 (73.4, 96)

108 (85, 171)

0.5

Donor height (cm) a

172.5 (±14.5)

174.4 (±7)

172.1 (±8.8)

173.7 (±10.8)

169.9 (±10.6)

179.3 (±4)

0.5

Cold ischemia Time (h) a

20 (±13.5)

23.7 (±13.3)

19.3 (±14)

24.6 (±10.6)

19.7 (±10)

28 (±8.5)

0.6

Pre-procurement antibiotics

13 (59%)

13 (68%)

13 (93%)

16 (89%)

12 (52%)

2 (67%)

0.05

NDD

19 (86%)

18 (95%)

13 (93%)

17 (94%)

20 (87%)

3 (100%)

0.9

Trauma

6 (27%)

5 (26%)

4 (29%)

5 (28%)

8 (35%)

2 (67%)

0.8

CPR

14 (64%)

10 (53%)

10 (71%)

9 (50%)

12 (52%)

1 (33%)

0.7

PaO2:FiO2 ratio a

224 (±74)

268 (±103)

237 (±136)

251 (±111)

242 (±100)

251 (±104)

0.7

Normal baseline AFC

17 (77%)

15 (79%)

11 (79%)

16 (89%)

20 (87%)

2 (67%)

0.9

AFC at baseline b

33.4 (9.5, 45.5)

27.3 (9.2, 40)

18.4 (15.4, 32.2)

28.8 (15, 33.3)

28 (18.2, 38.9)

20.6 (4.3, 49.1)

0.9

AFC at 5h b

14 (9.5, 36.2)

18.7 (9.5, 29.7)

2.7 (0, 16.9)

22.7 (14.8, 32)

15.2 (13.3, 32.4)

5 (0, 10)

0.02

Start lung weight (g) b

402 (330, 532)

383 (351, 438)

372 (294, 396)

365 (297, 406)

360 (328, 414)

555 (373, 562)

0.2

End lung weight (g) b

631 (564, 958)

784 (720, 1232)

767 (603, 891)

722 (630, 774)

779 (696, 987)

1328 (1312, 1344)

0.1

% weight gain b

62 (44, 99)

115 (69, 186)

98 (83, 154)

99 (80, 128)

101 (82, 134)

138 (133, 142)

0.04

  1. *Abbreviations: NDD Neurological declaration of death, CPR Cardiopulmonary resuscitation, AFC Alveolar fluid clearance
  2. *Continuous data presented as means ± standard deviation (a) or medians with interquartile range (b)
  3. *Group comparisons of continuous variables made using Kruskal–Wallis test
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