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Table 1 Characteristics of the 99 donor lungs stratified by 6 experimental conditions.

From: The endogenous capacity to produce proinflammatory mediators by the ex vivo human perfused lung

  With blood
n=55
Without Blood
n=44
P-value
Control lungs
n=22
IV bacteria
n=19
Airspace bacteria
n=14
Control lungs
n=18
IV bacteria
n=23
Airspace bacteria
n=3
Donor age b 44 (30, 55) 45 (32, 54) 45.5 (30, 55) 40 (38, 46) 53 (32, 64) 59 (55, 69) 0.4
Donor sex 15 (68%) 13 (68%) 9 (64%) 11 (61%) 16 (70%) 3 (100%) 0.9
Donor weight (kg) b 88.5 (83.1, 104.3) 86.9 (72.7, 96) 83.9 (66.5, 112) 89.7 (75, 104) 83 (73.4, 96) 108 (85, 171) 0.5
Donor height (cm) a 172.5 (±14.5) 174.4 (±7) 172.1 (±8.8) 173.7 (±10.8) 169.9 (±10.6) 179.3 (±4) 0.5
Cold ischemia Time (h) a 20 (±13.5) 23.7 (±13.3) 19.3 (±14) 24.6 (±10.6) 19.7 (±10) 28 (±8.5) 0.6
Pre-procurement antibiotics 13 (59%) 13 (68%) 13 (93%) 16 (89%) 12 (52%) 2 (67%) 0.05
NDD 19 (86%) 18 (95%) 13 (93%) 17 (94%) 20 (87%) 3 (100%) 0.9
Trauma 6 (27%) 5 (26%) 4 (29%) 5 (28%) 8 (35%) 2 (67%) 0.8
CPR 14 (64%) 10 (53%) 10 (71%) 9 (50%) 12 (52%) 1 (33%) 0.7
PaO2:FiO2 ratio a 224 (±74) 268 (±103) 237 (±136) 251 (±111) 242 (±100) 251 (±104) 0.7
Normal baseline AFC 17 (77%) 15 (79%) 11 (79%) 16 (89%) 20 (87%) 2 (67%) 0.9
AFC at baseline b 33.4 (9.5, 45.5) 27.3 (9.2, 40) 18.4 (15.4, 32.2) 28.8 (15, 33.3) 28 (18.2, 38.9) 20.6 (4.3, 49.1) 0.9
AFC at 5h b 14 (9.5, 36.2) 18.7 (9.5, 29.7) 2.7 (0, 16.9) 22.7 (14.8, 32) 15.2 (13.3, 32.4) 5 (0, 10) 0.02
Start lung weight (g) b 402 (330, 532) 383 (351, 438) 372 (294, 396) 365 (297, 406) 360 (328, 414) 555 (373, 562) 0.2
End lung weight (g) b 631 (564, 958) 784 (720, 1232) 767 (603, 891) 722 (630, 774) 779 (696, 987) 1328 (1312, 1344) 0.1
% weight gain b 62 (44, 99) 115 (69, 186) 98 (83, 154) 99 (80, 128) 101 (82, 134) 138 (133, 142) 0.04
  1. *Abbreviations: NDD Neurological declaration of death, CPR Cardiopulmonary resuscitation, AFC Alveolar fluid clearance
  2. *Continuous data presented as means ± standard deviation (a) or medians with interquartile range (b)
  3. *Group comparisons of continuous variables made using Kruskal–Wallis test