Table 1 Outcomes grouped by peak TNF-α post-LPS challenge
Tertile 1 (Low TNF-α levels) (n = 67) | Tertile 2 (Medium TNF-α levels) (n=67) | Tertile 3 (High TNF-α levels) (n=67) | Total cohort (n=201) | P-value | |
|---|---|---|---|---|---|
Suspected nosocomial infection: N (%) | 31 (46%) | 39 (58%) | 39 (58%) | 109 (54%) | |
Total positive adjudicated infections: n | 16 | 22 | 29 | 67 | 0.494 |
Adjudicated positive infections per subject: Mean ± SD | 0.2 ± 0.5 | 0.3 ± 0.7 | 0.4 ± 0.8 | 0.3 ± 0.7 | 0.066 |
Source of positive infections | |||||
Surgical | 2 (12.5%) | 1 (4.5%) | 1 (3.4%) | 4 (2.0%) | |
Skin-soft tissue | 0 (0.0%) | 1 (4.5%) | 2 (6.9%) | 3 (1.5%) | |
Catheter BSI | 0 (0.0%) | 1 (4.5%) | 4 (13.8%) | 5 (2.5%) | |
Primary BSI | 0 (0.0%) | 3 (13.6%) | 3 (10.3%) | 6 (3.0%) | |
UTI | 0 (0.0%) | 4 (18.2%) | 6 (20.7%) | 10 (14.9%) | |
Intra-abdominal | 0 (0.0%) | 2 (9.1%) | 0 (0.0%) | 2 (1.0%) | |
Lower RTI | 6 (37.5%) | 2 (9.1%) | 2 (6.9%) | 10 (5.0%) | |
ICU Pneumonia | 6 (37.5%) | 7 (31.8%) | 11 (37.9%) | 24 (11.9%) | |
Other | 2 (12.5%) | 1 (4.5%) | 0 (0.0%) | 3 (1.5%) | |
ICU Mortality: n (%) | 21 (31.3%) | 21 (31.3%) | 23 (34.3%) | 65 (32.3%) | 0.913 |
Hospital mortality: n (%) | 23 (34.3%) | 21 (31.3%) | 26 (38.8%) | 70 (34.8%) | 0.659 |
90-day mortality: n (%) | 24 (35.8%) | 24 (35.8%) | 28 (41.8%) | 76 (37.8%) | 0.713 |
ICU length of stay | 0.552 | ||||
Median [IQR] | 9.1 [5.5 to 13.8] | 9.0 [6.9 to 13.3] | 9.0 [5.3 to 15.9] | 9.0 [5.9 to 15.2] | |
Hospital length of stay | 0.237 | ||||
Median [IQR] | 17.6 [7.7 to 30.3] | 14.6 [8.5 to 33.9] | 19.1 [9.0 to 34.0] | 16.8 [8.5 to 32.3] | |