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Table 2 Outcomes grouped by change in TNF-α post-LPS challenge

From: The relationship between immune status as measured by stimulated ex-vivo tumour necrosis factor alpha levels and the acquisition of nosocomial infections in critically ill mechanically ventilated patients

 

Tertile 1

((Post-LPS) - (Pre-LPS) <= -3.09

(n=66)

Tertile 2

((Post-LPS) - (Pre-LPS) <= 19.42

(n=67)

Tertile 3

((Post-LPS) - (Pre-LPS) > 19.42

(n=67)

Total cohort

(n=200)

P-value

Suspected nosocomial infection: N (%)

34 (52%)

35 (52%)

39 (58%)

108 (54%)

 

Total positive adjudicated infections: n

21

16

29

66

0.489

Adjudicated positive infections per subject: Mean ± SD

0.3 ± 0.7

0.2 ± 0.5

0.4 ± 0.8

0.3 ± 0.7

0.22

Source of positive infections

 Surgical

2 (9.5%)

1 (6.3%)

1 (3.4%)

4 (2.0%)

 

 Skin-soft tissue

1 (4.8%)

0 (0.0%)

2 (6.9%)

3 (1.5%)

 

 Catheter BSI

1 (4.8%)

0 (0.0%)

4 (13.8%)

5 (2.5%)

 

 Primary BSI

3 (14.3%)

0 (0.0%)

3 (10.3%)

6 (3.0%)

 

 UTI

2 (9.5%)

2 (12.5%)

6 (20.7%)

10 (14.9%)

 

 Intra-abdominal

1 (4.8%)

1 (6.3%)

0 (0.0%)

2 (1.0%)

 

 Lower RTI

2 (9.5%)

6 (37.5%)

2 (6.9%)

10 (5.0%)

 

 ICU Pneumonia

9 (42.9%)

4 (25.0%)

10 (34.5%)

23 (11.5%)

 

 Other

0 (0.0%)

2 (12.5%)

1 (3.4%)

3 (1.5%)

 

ICU Mortality: n (%)

24 (36.4%)

20 (29.9%)

21 (31.3%)

65 (32.5%)

0.703

Hospital mortality: n (%)

25 (37.9%)

21 (31.3%)

24 (35.8%)

70 (35.0%)

0.721

90-day mortality: n (%)

26 (39.4%)

24 (35.8%)

26 (38.8%)

76 (38.0%)

0.901

ICU length of stay

    

0.743

 Median [IQR]

9.1 [5.5 to 13.8]

9.0 [6.9 to 13.3]

9.0 [5.3 to 15.9]

9.0 [5.9 to 15.2]

 

Hospital length of stay

    

0.699

 Median [IQR]

17.6 [7.7 to 30.3]

14.6 [8.5 to 33.9]

19.1 [9.0 to 34.0]

16.8 [8.5 to 32.3]