Table 4 Baseline characteristics grouped by change in TNF-α post-LPS challenge
Tertile 1 ((Post-LPS) - (Pre-LPS) <= -3.09 (n=66) | Tertile 2 ((Post-LPS) - (Pre-LPS) <= 19.42 (n=67) | Tertile 3 ((Post-LPS) - (Pre-LPS) > 19.42 (n=67) | Total Cohort (n=200) | P-value | |
|---|---|---|---|---|---|
Age: Mean ± SD | 68.6 ± 12.8 | 62.6 ± 15.7 | 61.1 ± 15.7 | 64.1 ± 15.1 | 0.021 |
Sex: Female | 36 (54.5%) | 32 (47.8%) | 29 (43.3%) | 97 (48.5%) | 0.425 |
Primary Diagnosis | 0.045 | ||||
Cardiovascular | 13 (19.7%) | 12 (17.9%) | 7 (10.4%) | 32 (16.0%) | |
Respiratory | 19 (28.8%) | 21 (31.3%) | 16 (23.9%) | 56 (28.0%) | |
Neurologic | 5 (7.6%) | 9 (13.4%) | 15 (22.4%) | 29 (14.5%) | |
Sepsis | 13 (19.7%) | 17 (25.4%) | 14 (20.9%) | 44 (22.0%) | |
Trauma | 3 (4.5%) | 6 (9.0%) | 6 (9.0%) | 15 (7.5%) | |
Other | 13 (19.7%) | 2 (3.0%) | 9 (13.4%) | 14 (7.0%) | |
APACHE II: Mean ± SD | 26.7 ± 6.1 | 23.8 ± 7.7 | 25.0 ± 9.7 | 25.2 ± 8.0 | 0.037 |
Vasopressor support: N (%) | 59 (89.4%) | 49 (73.1%) | 42 (62.7%) | 150 (75.0%) | 0.002 |
Temperature: Mean °C ± SD | 37.9 ± 0.8 | 37.8 ± 1.0 | 38.0 ± 0.9 | 37.9 ± 0.9 | 0.397 |
On Antibiotics | 0.388 | ||||
N (%) | 46 (69.7%) | 40 (59.7%) | 40 (59.7%) | 126 (63.0%) | |
Positive culture 48 hrs prior to/after randomization: N (%) | 58 (87.9%) | 60 (89.6%) | 54 (80.6%) | 172 (86.0%) | 0.284 |
Highest white blood cell: mean ± SD | 15.5 ± 8.0 | 17.0 ± 8.2 | 16.4 ± 8.0 | 16.3 ± 8.0 | 0.617 |
Serum TNF-α: Mean pg/mL ± SD | 31.0 ± 68.5 | 3.7 ± 3.4 | 9.9 ± 19.0 | 14.8 ± 42.4 | <0.001 |
Post-LPS TNF-α: Mean pg/mL ± SD | 6.4 ± 18.0 | 6.0 ± 7.8 | 253.0 ± 301.0 | 88.9 ± 209.3 | <0.001 |
Serum IL-6: Mean pg/mL ± SD | 1600.6 ± 6195.2 | 130.5 ± 443.0 | 200.9 ± 484.8 | 636.6 ± 3615.2 | 0.01 |
Serum IL-10: Mean pg/mL ± SD | 147.2 ± 695.7 | 45.6 ± 75.3 | 52.7 ± 74.8 | 81.3 ± 403.9 | 0.775 |