Table 1 Systemic hemodynamics, arterial lactate levels and whole-body venous lactate efflux
Parameters | BL | 3 h | 6 h | 12 h | 18 h | End |
|---|---|---|---|---|---|---|
Heart rate (beats/min) | 106 (74–178) | 124 (83–214) | 142 (81–222) | 162 (86–222) | 157 (77–200) | 149 (74–206) |
MAP (mm Hg) | 70 (46–117) | 78 (40–123) | 73 (45–131) | 75 (38–116) | 74 (33–109) | 68 (31–135) |
MPAP (mm Hg) | 17 (11–29) | 23 (11–55) | 21 (12–37) | 24 (14–38) | 23 (15–38) | 25 (14–43) |
CVP (mm Hg) | 4 (0–10) | 5 (1–12) | 6 (2–12) | 7 (1–15) | 7 (2–14) | 8 (2–18) |
Cardiac output (ml/kg/min) | 78 (50–120) | 88 (38–154) | 93 (53–146) | 90 (47–202) | 101 (40–167) | 105 (38–301) |
SVRI (mm Hg l/kg/min) | 836 (501–1347) | 869 (346–2274) | 808 (408–1972) | 776 (410–1249) | 684 (151–1471) | 598 (198–1315) |
SvO2 (%) | 50 (33–67) | 55 (18–70) | 55 (8–75) | 55 (19–69) | 57 (16–70) | 53 (6–73) |
DO2 (ml/min) | 384 (224–654) | 421 (200–991) | 447 (236–781) | 407 (190–816) | 441 (161–700) | 440 (150–980) |
VO2 (ml/min) | 181 (96–274) | 178 (108–310) | 184 (109–311) | 181 (115–393) | 190 (105–282) | 197 (105–363) |
O2ER | 0.48 (0.32–0.66) | 0.42 (0.27–0.74) | 0.44 (0.23–0.91) | 0.43 (0.26–0.75) | 0.41 (0.28–0.84) | 0.43 (0.24–0.94) |
Lactate (mmol/l) | 0.6 (0.4–2.3) | 0.8 (0.2–2.7) | 0.7 (0.4–2.2) | 0.8 (0.5–3.6) | 0.7 (0.4–2.0) | 1.0 (0.4–7.0) |
Lactate disappearance (%) | − 16 (− 286 to 43) | 1 (− 339 to 54) | − 5 (− 184 to 49) | − 7 (− 308 to 34) | ||
Whole-body venous lactate efflux (µmol/kg/min) | 47.5 (28.9–139.0) | 68.8 (22.9–222.6) | 71.8 (27.8–301.4) | 70.8 (30.0–183.4) | 79.9 (30.4–237.8) | 91.9 (29.3–513.8) |