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Intensive Care Medicine Experimental

Table 3 Regional blood flow, lactate uptake and venous–arterial CO2 to arterial–venous O2 content difference ratio

From: Regional venous–arterial CO2 to arterial–venous O2 content difference ratio in experimental circulatory shock and hypoxia

Parameters

BL

3 h

6 h

12 h

18 h

End

Total hepatic blood flow (ml/kg/min)

22.3 (9.7–37.8)

22.5 (12.0–35.2)

24.0 (12.0–41.0)

25.3 (8.7–49.1)

28.3 (9.4–50.3)

27.3 (8.4–55.7)

Total hepatosplanchnic blood flow (ml/kg/min)

23.7 (14.7–42.9)

23.5 (9.9–39.4)

25.4 (15.1–40.7)

27.6 (16.5–50.4)

31.4 (14.0–55.0)

31.1 (9.7–69.2)

Hepatic lactate uptake (µmol/kg/min)

8.5 (2.1–26.5)

10.0 (3.5–30.1)

9.8 (− 2.4 to 30.0)

10.9 (0.8–22.4)

9.8 (− 0.5 to 23.4)

10.8 (− 22.8–25.4)

Hepatosplanchnic lactate uptake (µmol/kg/min)

6.8 (0.0–60.1)

7.4 (− 7.2 to 43.9)

8.2 (− 3.8 to 27.6)

8.2 (− 0.7 to 25.1)

8.2 (− 2.3 to 33.7)

7.2 (− 32.3–31.6)

Lactate hepatic vein − hepatic artery (µmol/l)

− 0.3 (− 1.6 to 0.0)

− 0.3 (− 1.8 to 0.4)

− 0.3 (− 1.3 to 0.1)

− 0.3 (− 1.0 to 0.0)

− 0.3 (− 1.6 to 0.2)

− 0.3 (− 1.3 to 1.4)

Lactate hepatic vein − portal vein (µmol/l)

− 0.4 (− 0.6 to -0.1)

− 0.5 (− 2.1 to -0.1)

− 0.4 (− 1.0 to 0.1)

− 0.4 (− 1.2 to 0.0)

− 0.4 (− 1.6 to 0.0)

− 0.4 (− 0.9 to 1.7)

Hepatic Cv-aCO2/Ca-vO2

0.7 (0.0–1.6)

0.8 (0.1–3.2)

0.8 (0.1–2.9)

0.8 (0.2–2.2)

0.9 (0.5–2.1)

0.9 (0.2–6.9)

Hepatosplanchnic Cv-aCO2/Ca-vO2

1.0 (0.4–1.5)

1.0 (0.4–2.3)

1.0 (0.7–2.1)

1.0 (0.5–1.5)

1.0 (2.2–1.5)

1.0 (0.2–3.4)

Renal artery blood flow (ml/kg/min)

5.2 (1.4–9.5)

4.8 (1.1–9.3)

4.7 (2.0–12.5)

5.4 (1.7–10.7)

5.4 (1.8–10.4)

4.9 (0.8–11.8)

Renal lactate uptake (µmol/kg/min)

0.0 (− 3.9 to 8.5)

− 0.2 (− 5.1 to 6.9)

− 0.6 (− 5.4 to 1.2)

− 0.4 (− 5.9 to 3.0)

− 0.7 (− 5.2 to 3.4)

− 0.2 (− 5.7 to 6.3)

Renal lactate gradient (µmol/l)

0.0 (− 1.4 to 1.4)

0.0 (− 1.2 to 1.0)

0.1 (− 0.3 to 1.0)

0.1 (− 0.8 to 1.8)

0.2 (− 0.4 to 1.0)

0.1 (− 0.9 to 1.4)

Renal Cv-aCO2/Ca-vO2

1.2 (0.4–2.8)

1.0 (0.4–2.3)

1.1 (0.1–2.2)

1.2 (0.1–3.2)

1.1 (0.5–2.5)

1.1 (0.3–4.7)

Renal Pv-aCO2/Ca-vO2 (mmHg ml O2/dl)

1.4 (0.1–3.1)

1.4 (0.0–3.3)

1.3 (0.2–2.2)

1.7 (0.5–6.0)

1.7 (0.7–3.1)

1.7 (0.7–6.2)

Superior mesenteric artery blood flow (ml/kg/min)

15.5 (9.4–35.1)

15.9 (6.9–26.8)

16.7 (8.1–31.9)

17.5 (10.7–39.9)

18.3 (8.9–43.9)

18.8 (7.1–47.8)

Gut lactate uptake (µmol/kg/min)

− 1.7 (− 12.9–40.4)

− 2.0 (− 11.8–20.8)

− 2.0 (− 22.8–11.0)

− 2.1 (− 11.3–9.5)

− 2.5 (− 12.7–4.5)

− 2.6 (− 12.7–23.2)

Gut lactate gradient (µmol/l)

0.1 (− 1.2 to 0.8)

0.1 (− 1.2 to 0.8)

0.1 (− 0.6 to 1.3)

0.1 (− 0.5 to 0.6)

0.1 (− 0.3 to 0.5)

0.1 (− 1.9 to 0.8)

Gut Cv-aCO2/Ca-vO2

1.3 (0.5–3.9)

1.2 (0.3–2.8)

1.3 (0.5–3.0)

1.2 (0.1–2.1)

1.3 (0.4–2.0)

1.2 (0.4–5.0)

Gut Pv-aCO2/Ca-vO2 (mmHg ml O2/dl)

2.2 (0.2–6.8)

2.2 (0.7–4.2)

2.5 (1.1–4.0)

2.5 (1.5–4.5)

2.8 (1.5–4.2)

3.0 (1.1–8.4)

Spleen artery blood flow (ml/kg/min)

1.0 (0.2–3.3)

1.0 (0.4–4.6)

1.3 (0.2–4.9)

1.2 (0.2–5.2)

1.3 (0.2–6.6)

1.3 (0.1–8.2)

Spleen lactate uptake (µmol/kg/min)

− 0.1 (− 2.1 to 1.6)

− 0.3 (− 1.6 to 0.4)

− 0.3 (− 1.7 to 0.4)

− 0.2 (− 1.1 to 0.6)

− 0.2 (− 1.4 to 0.4)

− 0.3 (− 1.8 to 1.8)

Spleen lactate gradient (µmol/l)

0.1 (− 1.0 to 1.1)

0.2 (− 0.8 to 1.0)

0.2 (− 0.4 to 1.1)

0.2 (− 0.4 to 1.1)

0.2 (− 0.3 to 0.8)

0.2 (− 0.9 to 2.6)

Spleen Cv-aCO2/Ca-vO2

1.3 (0.4–3.2)

1.1 (0.3–2.9)

1.2 (0.2–3.1)

1.3 (0.0–5.6)

1.3 (0.3–3.9)

1.1 (0.5–6.0)

Spleen Pv-aCO2/Ca-vO2 (mmHg ml O2/dl)

2.2 (0.8–3.2)

2.3 (1.1–6.8)

2.4 (0.1–4.0)

2.4 (1.3–7.5)

2.6 (0.3–5.3)

2.9 (0.3–8.4)

  1. Values represent median and range. BL = baseline, End = end of the experiment (at 24 h of resuscitation or before death if earlier). Regional blood flow was expressed as ml/kg/min. Total hepatic blood flow = hepatic arterial blood flow + portal vein blood flow, total hepatosplanchnic blood flow = celiac trunk blood flow + superior mesenteric artery blood flow, hepatic lactate uptake = hepatic lactate influx − hepatic lactate efflux, hepatosplanchnic lactate uptake = (arterial lactate − hepatic venous lactate) * total hepatic blood flow, Cv-aCO2/Ca-vO2 = venous–arterial CO2 to arterial–venous O2 content difference ratio, regional lactate uptake (renal, gut and spleen) = regional lactate influx − regional lactate efflux, regional lactate gradient (renal, gut and spleen) = regional venous lactate − arterial lactate, Pv-aCO2/Ca-vO2 = ratio between venous-to-arterial carbon dioxide difference and arterial–venous oxygen content difference
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