From: Endotoxemia and circulating bacteriome in severe COVID-19 patients
Characteristic | Total (N = 19) | EAA ≥ 0.6 (N = 8) | EAA < 0.6 (N = 11) |
---|---|---|---|
Age, years | 54 (43, 59) | 49 (40, 59) | 57 (48, 58) |
Male | 15 (79%) | 6 (75) | 9 (82) |
APACHE II score | 8 (4, 11) N = 13 | 9 (5, 10) N = 5 | 7.5 (4.0, 11.5) N = 8 |
SOFA score | 6 (3, 10) | 5 (3, 11) N = 5 | 6 (3.5, 9) N = 8 |
PaO2/FiO2 ratio at enrollment | 233 (186, 261) N = 13 | 246 (186, 293) N = 5 | 223 (187, 254) N = 8 |
Underlying disease | |||
 Hypertension | 6 (32) | 1 (13) | 5 (45) |
 Diabetes | 8 (42) | 2 (25) | 6 (55) |
 Chronic kidney disease | 2 (11) | 0 | 2 (18) |
 Time from onset of fever to hospital admission (days) | 5 (3, 7) | 3.5 (2, 5) | 7 (5, 8) |
 Time from onset of fever to 1st EAA measurement (days) | 9 (9, 11) | 9 (6, 12.5) | 9 (9, 11) |
 ICU admission (%) | 13 (68.4) | 5 (62.5) | 8 (72.7) |
 Serum creatinine, mg/dL | 0.90 (0.80, 1.16) | 0.82 (0.69, 1.07) | 0.91 (0.86, 1.28) |
 EAA level | 0.57 (0.47, 0.86) | 0.86 (0.80, 0.90) | 0.48 (0.42, 0.57) |
 Cycle threshold | 23.9 (18.3, 27.7) | 23.7 (15.8, 27.0) | 24.9 (18.3, 30.1) |
 Ferritin | 872 (638, 2409) | 740 (417, 2047) | 1057 (750, 2771) |
 CRP | 127 (27.5, 1457) | 38 (27.5, 130) | 137 (70, 175) |
 Procalcitonin | 0.16 (0.07, 0.55) | 0.11 (0.03, 2.34) | 0.24 (0.09, 0.43) |
Treatment | |||
 Darunavir | 9 (47) | 6 (75) | 3 (27) |
 Ritonavir | 9 (47) | 6 (75) | 3 (27) |
 Favipiravir | 18 (95) | 7 (88) | 11 (100) |
 Antimalarial drug | 18 (95) | 8 (100) | 10 (91) |
 Azithromycin | 13 (68) | 6 (75) | 7 (64) |
 Corticosteroid | 4 (21) | 3 (38) | 1 (9) |
 Antibiotic | 13 (68) | 5 (63) | 8 (73) |