Table 2 Molecular mechanism of argon
From: Update of the organoprotective properties of xenon and argon: from bench to beside
Argon | ||||
|---|---|---|---|---|
Author | Effects revealed in human | Effects revealed in in vivo | Effects revealed in in vitro | Organprotection |
Loetscher et al. [101], Fahlenkamp et al. [102], Ulbrich et al. [103] | Activation of MEK-ERK 1/2pathway | Brain | ||
Abraini et al. [104] | Binding to GABAA-receptor | Brain | ||
Fahlenkamp et al. [105] | ↑ IL-1beta, ↑IL-6, ↑iNOS, ↑TGF-beta, | Brain | ||
Zhuang et al. [106] | ↑ Bcl-2 | Brain | ||
Ulbrich et al. [107] | Inhibition TLR 2/4 | Brain | ||
Ulbrich et al. [103] | ↑ERK1/2,↑Heme-oxygenase-1 | Brain | ||
Zhao et al. [108] | PI3K Signaling, ↑Nrf2 | Brain | ||