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Intensive Care Medicine Experimental
Fig. 2 | Intensive Care Medicine Experimental

Fig. 2

From: Cytokine pre-activation of cryopreserved xenogeneic-free human mesenchymal stromal cells enhances resolution and repair following ventilator-induced lung injury potentially via a KGF-dependent mechanism

Fig. 2

Pre-activated, cryopreserved, XF-hMSCs restore lung function after VILI. All MSC treatments significantly restored arterial PO2, with pre-activated cryopreserved cells statistically better than their naive alternatives (a). For static lung compliance, only activated fresh and activated frozen delivery showed significant restoration and were statistically different to their naive counterparts (b). All treatment groups restored the lung wet to dry ratio (c), but only pre-activated MSCs modulated BAL protein content (d). *, ** and ***P < 0.05, 0.01 and 0.001, respectively, versus PBS control groups; $P < 0.05 versus corresponding naive groups. Sham, n = 5–6; PBS control, n = 7–8; fresh, n = 7–8; fresh pre-activated, n = 6–8; cryopreserved, n = 5–6; cryopreserved pre-activated, n = 6–7

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