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Intensive Care Medicine Experimental
Fig. 5 | Intensive Care Medicine Experimental

Fig. 5

From: Cytokine pre-activation of cryopreserved xenogeneic-free human mesenchymal stromal cells enhances resolution and repair following ventilator-induced lung injury potentially via a KGF-dependent mechanism

Fig. 5

Pre-activation enhances the efficacy of hMSC CM in promoting pulmonary epithelial wound healing. FBS-hMSC CM and XF-hMSC CM comparably enhanced wound repair in comparison with the MEM-α control (a). Pre-activation of these MSCs further enhanced the ability of the CM to improve wound repair but this was attenuated by KGF neutralization (b). Representative images are provided (c). Note: * and *** = P < 0.05 and 0.001 versus MEM-α; and $ and $$ = P < 0.05 and 0.01, versus respective naive FBS or XF-hMSC CM; # = P < 0.05 versus respective pre-activated FBS or XF-hMSC CM. 0 h, n = 16; MEM-α control, n = 7–12; all other groups, n = 4–6

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