Fig. 3
From: Time-dependent effects of histone deacetylase inhibition in sepsis-associated acute kidney injury
Short-term effect. Treatment effects measured at treatment day 3. a Representative images of immune staining of markers of mononuclear cells and their phenotype. Scale bar = 20 μm. b–d Dot plots of F4/80+ MNC cell numbers per field, the stain intensities of iNOS+ and MR+ colocalized with F4/80+ for group animals (mean ± SD, N = 7~12). Tukey’s test was used to determine statistical significance. e Heat map of renal mRNA expressions of inflammation and matrix remodeling mediator markers (N = 6~8). *P < 0.05, **P < 0.01 compared to the CLP + vehicle group. iNOS, inducible nitric oxide synthases; F4/80, also known as EMR1, EGF-like module-containing mucin-like hormone receptor-like 1; MR, mannose receptor; nfkb, nuclear factor kappa B; ccl10, C-C Motif Chemokine Ligand 20; icam, intercellular adhesion molecule; traf, tumor necrosis factor receptor-associated factor; kim1, also known as HAVCR1, hepatitis A virus cellular receptor 1; lox, lysyl oxidase; loxl1, lysyl oxidase homolog 1