Fig. 1

Patient enrollment, study design and different clinical parameters of COVID-19 patients. a Summary of recruited COVID-19 patients, including 18 severe patients, 4 critical survivors, and 11 critical non-survivors. b Admission days and multi-omics sample collection time of COVID-19 patients. Datasets contained 113 transcriptome, 85 proteome, 85 metabolome, 85 lipidome were collected from 33 patients. Grey bar records time from disease onset to admission by weeks; colored bar records time from admission to outcome-time-point by days. Points represent multi-omics data sampling time. The details of enrolled patients were shown in Additional file 1: Table S1. c The age and gender distribution and comparison of 33 COVID-19 patients. *p < 0.05. d The clinical parameters of COVID-19 patients. 123 clinical data were collected. ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05. WBC, white blood cells; Lymph, lymphocyte; NEU, neutrophil; PLT, platelet; Hb, hemoglobin; ALT, alanine transaminase; AST, aspartate aminotransferase; TBIL, total bilirubin; ALB, albumin; GLO, globulin; CRP, C-reactive protein; IL6, interleukin-6; IL10, interleukin-10; IL8, interleukin-10; TNFα, tumor necrosis factor alpha; IL1β, interleukin-1 beta; IL2R, Interleukin-2 receptor; ESR, erythrocyte sedimentation rate; PCT, procalcitonin; D-dimer, fibrin D-dimer