Fig. 2
From: Haptoglobin treatment prevents cell-free hemoglobin exacerbated mortality in experimental rat sepsis
Mortality studies in septic rats. Septic rats were randomized to treatment with a bolus followed by a continuous infusion of saline, Hb, or Hb–haptoglobin over 24 h. All investigators were blinded for the treatment group. An additional group of non-septic rats was infused with Hb to exclude toxicity in healthy animals. a Heart rate recordings (mean ± S.E.M) during the 48 h experiments. b Kaplan–Meier survival curves. Results of the statistical analysis are provided in the table (c). Survival proportions (Kaplan–Meier) were compared using a two-tailed Gehan–Breslow–Wilcoxon test. The familywise significance level of 0.05 was divided by the number of all possible comparisons (n = 6), resulting in a Bonferroni-corrected multiple-comparison significance level of 0.00833. [GraphPad Prism software version 8.0 (GraphPad Software, San Diego, CA, USA)]. Numbers of dead animals/total animals per group are given in parentheses