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Table 1 Hemodynamics and blood gas values

From: The effect of targeting Tie2 on hemorrhagic shock-induced renal perfusion disturbances in rats

Parameter

HS

HS + VT

Baseline

1 h HS

R + 1 h

R + 4 h

Baseline

1 h HS

R + 1 h

R + 4 h

MAP (mmHg)

85 ± 13

27 ± 5 *

66 ± 14 *

65 ± 9 *

83 ± 9

26 ± 2 *

64 ± 11 *

57 ± 10 *

Heart rate (BPM)

369 ± 39

319 ± 36 *

336 ± 29 *

330 ± 30 *

367 ± 26

304 ± 25 *

342 ± 20 *

333 ± 24 *

Temperature

36.4 ± 0.7

36.0 ± 0.5

36.3 ± 0.5

36.2 ± 0.5

36.7 ± 0.6

36.1 ± 0.8 *

36.3 ± 0.6

36.3 ± 0.5

CVP (mmHg)

1 ± 1

2 ± 1

4 ± 2 *

6 ± 2 *

2 ± 1

2 ± 1

3 ± 1 *

5 ± 1 *

Respiratory rate (min−1)

65 ± 5

70 ± 5

75 ± 5 *

75 ± 5 *

65 ± 5

70 ± 5

75 ± 5 *

75 ± 5 *

pH

7.39 ± 0.07

7.30 ± 0.04 *

7.32 ± 0.05 *

7.29 ± 0.08 *

7.39 ± 0.04

7.31 ± 0.04 *

7.34 ± 0.04 *

7.29 ± 0.07 *

pCO2 (kPa)

5.47 ± 1.10

5.18 ± 0.81

6.06 ± 0.92

4.88 ± 0.91

5.03 ± 0.69

5.06 ± 0.60

5.57 ± 0.83

5.26 ± 1.33

HCO3− (mmol/L)

24.1 ± 1.4

18.5 ± 2.0 *

22.3 ± 1.6 *

17.5 ± 1.2 *

22.7 ± 2.3

19.1 ± 1.8 *

21.8 ± 2.1 *

17.8 ± 3.4 *

Base excess (mEq/L)

− 0.2 ± 1.0

− 6.8 ± 1.7 *

− 3.4 ± 1.5 *

− 7.8 ± 1.3 *

− 1.6 ± 2.0

− 6.5 ± 2.0 *

− 3.4 ± 1.6 *

− 7.4 ± 3.0 *

pO2 (kPa)

32.9 ± 8.2

33.7 ± 5.6

33.9 ± 5.1

33.5 ± 4.2

33.5 ± 7.7

33.5 ± 5.4

34.1 ± 5.6

32.1 ± 5.5

sO2 (%)

99.7 ± 0.3

99.8 ± 0.1

99.8 ± 0.1

99.8 ± 0.1

99.8 ± 0.3

99.8 ± 0.2

99.8 ± 0.1

99.7 ± 0.2

Hematocrit (%)

40 ± 2

31 ± 2 *

33 ± 2 *

24 ± 6 *

39 ± 4

32 ± 3 *

34 ± 3 *

26 ± 8 *

  1. Data are presented as mean ± SD. * P < 0.05 compared to the baseline value of the corresponding group. No differences were found between vasculotide (VT) and untreated HS rats. HS; hemorrhagic shock group, HS + VT; hemorrhagic shock group treated with vasculotide, 1 h HS; values measured at 1 h following start blood withdrawal, R + 1 h; values measured at 1 h following start of fluid resuscitation, R + 4 h; values measured at 4 h following of start fluid resuscitation, MAP; mean arterial pressure, CVP; central venous pressure,