From: The effect of targeting Tie2 on hemorrhagic shock-induced renal perfusion disturbances in rats
Parameter | HS | HS + VT | ||||||
---|---|---|---|---|---|---|---|---|
Baseline | 1 h HS | R + 1 h | R + 4 h | Baseline | 1 h HS | R + 1 h | R + 4 h | |
MAP (mmHg) | 85 ± 13 | 27 ± 5 * | 66 ± 14 * | 65 ± 9 * | 83 ± 9 | 26 ± 2 * | 64 ± 11 * | 57 ± 10 * |
Heart rate (BPM) | 369 ± 39 | 319 ± 36 * | 336 ± 29 * | 330 ± 30 * | 367 ± 26 | 304 ± 25 * | 342 ± 20 * | 333 ± 24 * |
Temperature | 36.4 ± 0.7 | 36.0 ± 0.5 | 36.3 ± 0.5 | 36.2 ± 0.5 | 36.7 ± 0.6 | 36.1 ± 0.8 * | 36.3 ± 0.6 | 36.3 ± 0.5 |
CVP (mmHg) | 1 ± 1 | 2 ± 1 | 4 ± 2 * | 6 ± 2 * | 2 ± 1 | 2 ± 1 | 3 ± 1 * | 5 ± 1 * |
Respiratory rate (min−1) | 65 ± 5 | 70 ± 5 | 75 ± 5 * | 75 ± 5 * | 65 ± 5 | 70 ± 5 | 75 ± 5 * | 75 ± 5 * |
pH | 7.39 ± 0.07 | 7.30 ± 0.04 * | 7.32 ± 0.05 * | 7.29 ± 0.08 * | 7.39 ± 0.04 | 7.31 ± 0.04 * | 7.34 ± 0.04 * | 7.29 ± 0.07 * |
pCO2 (kPa) | 5.47 ± 1.10 | 5.18 ± 0.81 | 6.06 ± 0.92 | 4.88 ± 0.91 | 5.03 ± 0.69 | 5.06 ± 0.60 | 5.57 ± 0.83 | 5.26 ± 1.33 |
HCO3− (mmol/L) | 24.1 ± 1.4 | 18.5 ± 2.0 * | 22.3 ± 1.6 * | 17.5 ± 1.2 * | 22.7 ± 2.3 | 19.1 ± 1.8 * | 21.8 ± 2.1 * | 17.8 ± 3.4 * |
Base excess (mEq/L) | − 0.2 ± 1.0 | − 6.8 ± 1.7 * | − 3.4 ± 1.5 * | − 7.8 ± 1.3 * | − 1.6 ± 2.0 | − 6.5 ± 2.0 * | − 3.4 ± 1.6 * | − 7.4 ± 3.0 * |
pO2 (kPa) | 32.9 ± 8.2 | 33.7 ± 5.6 | 33.9 ± 5.1 | 33.5 ± 4.2 | 33.5 ± 7.7 | 33.5 ± 5.4 | 34.1 ± 5.6 | 32.1 ± 5.5 |
sO2 (%) | 99.7 ± 0.3 | 99.8 ± 0.1 | 99.8 ± 0.1 | 99.8 ± 0.1 | 99.8 ± 0.3 | 99.8 ± 0.2 | 99.8 ± 0.1 | 99.7 ± 0.2 |
Hematocrit (%) | 40 ± 2 | 31 ± 2 * | 33 ± 2 * | 24 ± 6 * | 39 ± 4 | 32 ± 3 * | 34 ± 3 * | 26 ± 8 * |