Skip to main content
Intensive Care Medicine Experimental
Fig. 1 | Intensive Care Medicine Experimental

Fig. 1

From: Endothelial cell regulation of systemic haemodynamics and metabolism acts through the HIF transcription factors

Fig. 1

Effects of HIF-1α pulmonary and systemic endothelial knockout on constitutive cardiovascular function. Circadian variations in a systolic, b diastolic blood pressure, c heart rate, d subcutaneous temperature, e oxygen consumption and f carbon dioxide synthesis of HIF-1α Tie2 Cre (green, n = 4) and littermate HIF-1α flox/flox (grey, n = 4) mice were recorded by radio-telemetry. Black box represents nocturnal phase. Haemodynamic response to 10 mg/kg LPS bolus in HIF-1α Tie2 Cre (green, n = 3) and littermate HIF-1α flox/flox (grey, n = 3) mice on g systolic and H: diastolic blood pressures and i heart rate are displayed. Data are presented as a mean ± SEM for each 30 min period, p values for area under the curve followed by unpaired t test are shown

Back to article page