Table 1 Haemodynamics, ventricular function and volumes and heart failure markers in pulmonary artery-banded (PAB) animals and controls
Control (n = 6) | PAB (n = 5) | p | |
|---|---|---|---|
Biometrics | |||
Body weight (kg) | 37.7 (0.9) | 37.8 (4.5) | 1.0 |
BSA (m2) | 0.8 (0.01) | 0.8 (0.06) | 1.0 |
Haemodynamics | |||
HR (min−1) | 81.8 (11.3) | 71.2 (7,9) | 0.1 |
CI (L/min/m2) | 5.3 (1.1) | 4.1 (0.5) | 0.04 |
SVi (ml/m2) | 64.6 (6.8) | 57.5 (2.2) | < 0.05 |
SAP (mmHg) | 90.2 (1.7) | 78 (6) | 0.01 |
DAP (mmHg) | 58 (9) | 52 (7) | 0.2 |
MAP (mmHg) | 71.8 (9) | 63.8 (7.8) | 0.2 |
SVRI (dyn·s/cm5/kg) | 1226 (355) | 1423 (97) | 0.2 |
PVRI (dyn·s/cm5/kg) | 140 (81) | 358 (99) | 0.005 |
RV Ea (mmHg/ml) | 0.58 (0.09) | 1.36 (0.4) | 0.001 |
LV Ea (mmHg/ml) | 1.76 (0.28) | 2.09 (0.82) | 0.4 |
Ventricle | |||
RV Pmax (mmHg) | 27.4 (1.9) | 44.7 (9.7) | 0.02 |
LV Pmax (mmHg) | 84 (5.6) | 68 (4.8) | < 0.05 |
RV Pmean (mmHg) | 15.1 (1.0) | 23.2 (5.1) | 0.02 |
LV Pmean (mmHg) | 39.9 (5.0) | 42.7 (5.3) | 0.4 |
RV Pmin (mmHg) | 7.1 (1.1) | 6.6 (3.1) | 0.7 |
LV Pmin (mmHg) | 7.6 (1.8) | 7.6 (1.4) | 1.0 |
RV ESV (ml) | 36.6 (6.9) | 32.7 (18) | 0.7 |
LV ESV (ml) | 40.2 (6.7) | 12.7 (8.1) | 0.03 |
RV EDV (ml) | 65.3 (19.8) | 77.2 (10.1) | 0.2 |
LV EDV (ml) | 82.3 (7.9) | 55 (4.9) | 0.02 |
RV PRSW (mmHg·ml·ml−1) | 10 (3.5) | 15.2 (5.2) | 0.08 |
LV PRSW (mmHg·ml·ml−1) | 44 (8.8) | 41.8 (17.9) | 0.8 |
RV ESPVR (mmHg·ml−1) | 0.35 (0.12) | 1.07 (0.4) | 0.02 |
LV ESPVR (mmHg·ml−1) | 0.9 (0.08) | 1.32 (0.5) | 0.5 |
RV ESPVR V0 (ml) | − 31.8 (30.4) | 2.4 (11.7) | 0.04 |
LV ESPVR V0 (ml) | − 38.3 (16.9) | − 42.6 (18.3) | 0.7 |
RV dP/dtmax (mmHg/s) | 387.2 (93.6) | 542.8 (52.7) | 0.01 |
LV dP/dtmax (mmHg/s) | 1081 (240) | 1385 (322) | 0.1 |
RV Ea/ESPVR | 1.88 (0.8) | 1.34 (0.3) | 0.1 |
LV Ea/ESPVR | 1.78 (0.43) | 1.8 (0.57) | 0.96 |
RV EF (%) | 52.6 (6.6) | 52.8 (14) | 1.0 |
LV EF (%) | 56 (5) | 71 (12) | 0.03 |
RV dP/dtmin (mmHg/s) | − 378.5 (95) | − 677.5 (164.5) | 0.004 |
LV dP/dtmin (mmHg/s) | − 1680 (121) | − 1395 (324) | 0.1 |
RV tau (ms) | 75.4 (13.8) | 76.8 (17) | 0.9 |
LV tau (ms) | 47 (5.3) | 62 (13.4) | 0.03 |
RV EDPVR (mmHg/ml) | 0.16 (0.04) | 0.15 (0.05) | 0.7 |
LV EDPVR (mmHg/ml) | 0.18 (0.06) | 0.23 (0.05) | 0.4 |
Biochemistry | |||
Lactate (mM) | 1.0 (0.3) | 1.7 (0.3) | 0.007 |
NT-pro-BNP (pg/ml) | 6.3 (7.0) | 19.3 (8.9) | 0.02 |