Skip to main content

Table 1 Haemodynamics, ventricular function and volumes and heart failure markers in pulmonary artery-banded (PAB) animals and controls

From: Norepinephrine and dobutamine improve cardiac index equally by supporting opposite sides of the heart in an experimental model of chronic pulmonary hypertension

  Control (n = 6) PAB (n = 5) p
Biometrics
 Body weight (kg) 37.7 (0.9) 37.8 (4.5) 1.0
 BSA (m2) 0.8 (0.01) 0.8 (0.06) 1.0
Haemodynamics
 HR (min−1) 81.8 (11.3) 71.2 (7,9) 0.1
 CI (L/min/m2) 5.3 (1.1) 4.1 (0.5) 0.04
 SVi (ml/m2) 64.6 (6.8) 57.5 (2.2)  < 0.05
 SAP (mmHg) 90.2 (1.7) 78 (6) 0.01
 DAP (mmHg) 58 (9) 52 (7) 0.2
 MAP (mmHg) 71.8 (9) 63.8 (7.8) 0.2
 SVRI (dyn·s/cm5/kg) 1226 (355) 1423 (97) 0.2
 PVRI (dyn·s/cm5/kg) 140 (81) 358 (99) 0.005
 RV Ea (mmHg/ml) 0.58 (0.09) 1.36 (0.4) 0.001
 LV Ea (mmHg/ml) 1.76 (0.28) 2.09 (0.82) 0.4
Ventricle
 RV Pmax (mmHg) 27.4 (1.9) 44.7 (9.7) 0.02
 LV Pmax (mmHg) 84 (5.6) 68 (4.8)  < 0.05
 RV Pmean (mmHg) 15.1 (1.0) 23.2 (5.1) 0.02
 LV Pmean (mmHg) 39.9 (5.0) 42.7 (5.3) 0.4
 RV Pmin (mmHg) 7.1 (1.1) 6.6 (3.1) 0.7
 LV Pmin (mmHg) 7.6 (1.8) 7.6 (1.4) 1.0
 RV ESV (ml) 36.6 (6.9) 32.7 (18) 0.7
 LV ESV (ml) 40.2 (6.7) 12.7 (8.1) 0.03
 RV EDV (ml) 65.3 (19.8) 77.2 (10.1) 0.2
 LV EDV (ml) 82.3 (7.9) 55 (4.9) 0.02
 RV PRSW (mmHg·ml·ml−1) 10 (3.5) 15.2 (5.2) 0.08
 LV PRSW (mmHg·ml·ml−1) 44 (8.8) 41.8 (17.9) 0.8
 RV ESPVR (mmHg·ml−1) 0.35 (0.12) 1.07 (0.4) 0.02
 LV ESPVR (mmHg·ml−1) 0.9 (0.08) 1.32 (0.5) 0.5
 RV ESPVR V0 (ml) − 31.8 (30.4) 2.4 (11.7) 0.04
 LV ESPVR V0 (ml) − 38.3 (16.9) − 42.6 (18.3) 0.7
 RV dP/dtmax (mmHg/s) 387.2 (93.6) 542.8 (52.7) 0.01
 LV dP/dtmax (mmHg/s) 1081 (240) 1385 (322) 0.1
 RV Ea/ESPVR 1.88 (0.8) 1.34 (0.3) 0.1
 LV Ea/ESPVR 1.78 (0.43) 1.8 (0.57) 0.96
 RV EF (%) 52.6 (6.6) 52.8 (14) 1.0
 LV EF (%) 56 (5) 71 (12) 0.03
 RV dP/dtmin (mmHg/s) − 378.5 (95) − 677.5 (164.5) 0.004
 LV dP/dtmin (mmHg/s) − 1680 (121) − 1395 (324) 0.1
 RV tau (ms) 75.4 (13.8) 76.8 (17) 0.9
 LV tau (ms) 47 (5.3) 62 (13.4) 0.03
 RV EDPVR (mmHg/ml) 0.16 (0.04) 0.15 (0.05) 0.7
 LV EDPVR (mmHg/ml) 0.18 (0.06) 0.23 (0.05) 0.4
Biochemistry    
 Lactate (mM) 1.0 (0.3) 1.7 (0.3) 0.007
 NT-pro-BNP (pg/ml) 6.3 (7.0) 19.3 (8.9) 0.02
  1. Data are presented as means (SD)
  2. BSA, body surface area. CI, cardiac index. DAP, diastolic artery pressure. dP/dtmax, maximum pressure development over time. dP/dtmin, minimum pressure development over time. Ea: arterial elastance. EDV, end-diastolic pressure. EDP, end-diastolic pressure. EDPVR, end-diastolic pressure–volume relationship. EF, ejection fraction. ESPVR, end-systolic pressure–volume relationship. ESPVR V0, end-systolic pressure–volume relationship x-axis intercept. ESP, end-systolic pressure. ESV: end-systolic pressure. HR, heart rate. LV, left ventricle. MAP, mean artery pressure. NT-proBNP: N-terminal pro-brain natriuretic peptide. Ped, minimum ventricular pressure. Pmean, mean ventricular pressure. Pmax, maximum ventricular pressure. PRSW, preload recruitable stroke work. Ped, minimum ventricular pressure. PRSW, preload recruitable stroke work. RV, right ventricle. PVRI, pulmonary vascular resistance index. SAP, systolic artery pressure. SVi: stroke volume index. SVRI, systemic vascular resistance index. tau, isovolumic relaxation constant