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Intensive Care Medicine Experimental

Table 1 Plasma and urine concentrations and renal protein and gene expression levels of inflammatory, coagulation, and renal injury molecules

From: Preservation of renal endothelial integrity and reduction of renal edema by aprotinin does not preserve renal perfusion and function following experimental cardiopulmonary bypass

  

Baseline

60 min during CPB

60 min post-CPB

  

CPB control

CPB Aprotinin

CPB control

CPB Aprotinin

CPB control

CPB Aprotinin

Plasma

IL-6 (pg/ml)

21 ± 3

16 ± 9

71 ± 16*

85 ± 32*

772 ± 354*

775 ± 235*

 

vWF (ng/ml)

159 ± 40

163 ± 23

243 ± 32*

240 ± 57*

275 ± 98*

248 ± 54*

 

sTM (ng/ml)

0.2 ± 0.2

0.2 ± 0.2

1.0 ± 0.6*

1.1 ± 0.6*

6.0 ± 0.7*

6.0 ± 1.5*

 

TAT (ng/ml)

1.6 ± 0.8

1.7 ± 1.0

1.5 ± 0.7

1.6 ± 0.6

2.9 ± 1.4*

2.9 ± 1.0*

 

NGAL (ng/ml)

48 ± 7

43 ± 9

–

–

2012 ± 970*

1880 ± 700*

 

KIM-1 (pg/ml)

177 ± 27

193 ± 31

–

–

273 ± 81*

239 ± 48

 

Creatinine (nmol/ml)

23 ± 1

24 ± 1

–

–

58 ± 12*

57 ± 10*

Urine

NGAL (ng/ml)

–

–

–

–

659 ± 676

524 ± 387

 

KIM-1 (pg/ml)

–

–

–

–

1281 ± 865

1103 ± 703

Gene expression

ICAM-1

–

–

–

–

71 ± 56

68 ± 48

 

VCAM-1

–

–

–

–

1.8 ± 1.1

2.0 ± 0.8

 

E-selectin

–

–

–

–

0.09 ± 0.04

0.10 ± 0.05

 

P-selectin

–

–

–

–

0.11 ± 0.07

0.10 ± 0.04

 

PAR1

–

–

–

–

0.63 ± 0.30

0.78 ± 0.23

 

NGAL

–

–

–

–

29 ± 17

31 ± 16

 

KIM-1

–

–

–

–

9 ± 8

7 ± 6

Protein expression

PAR1

–

–

–

–

9.5 ± 6.7

10.0 ± 4.6

  1. Data are presented as mean ± standard deviation
  2. CPB cardiopulmonary bypass, IL-6 interleukin-6, ICAM-1 intracellular adhesion molecule 1, VCAM-1 vascular cell adhesion molecule 1, vWF von Willebrand Factor, sTM soluble thrombomodulin, TAT thrombin–antithrombin complex, PAR1 protease-activated receptor 1, NGAL neutrophil gelatinase-associated lipocalin, KIM-1 kidney injury molecule-1
  3. *p < 0.05 versus baseline, #p < 0.05 CPB control versus CPB aprotinin
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