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Intensive Care Medicine Experimental

Table 1 Patient characteristics on day 1, day 7 and day 14 of invasive mechanical ventilation

From: Risk factors for adverse outcomes during mechanical ventilation of 1152 COVID-19 patients: a multicenter machine learning study with highly granular data from the Dutch Data Warehouse

 

Day 1

Day 7

Day 14

 

(N = 1152)

(N = 761)

(N = 383)

Male

73% (N = 1139)

74% (N = 756)

76% (N = 380)

Age, years

66 (58–72, N = 1126)

65 (58–72, N = 753)

66 (58–72, N = 381)

 < 60

33%

33%

33%

 60–70

35%

36%

35%

 70–80

30%

29%

31%

 > 80

2%

2%

2%

BMI, kg/m2

27.8 (25.3–31.5, N = 988)

28.4 (25.5–31.9, N = 670)

28.1 (25.6–31.7, N = 328)

 < 25

23%

22%

23%

 25–30

44%

43%

44%

 30–35

21%

22%

20%

 > 35

12%

13%

13%

ICU mortality

28.8% (N = 1152)

30.4% (N = 761)

32.4% (N = 383)

ICU-free days

7 (0–21, N = 1152)

6 (0–21, N = 761)

3 (0–16, N = 383)

Ventilator-free days

15 (0–23, N = 1152)

16 (0–24, N = 761)

18 (0–25, N = 383)

Laboratory

   

CRP, mg/L

18 (104–267, N = 999)

171 (82–266, N = 718)

126 (60–196, N = 364)

Creatinine, micromol/L

83 (65–119, N = 1068)

89 (64–148, N = 732)

93 (61–156, N = 364)

D-dimer, ng/mL

1522 (893–3423, N = 354)

2600 (1509–4976, N = 417)

3120 (1900–4770, N = 241)

Lactate, mmol/L

1.2 (1.0–1.6, N = 1005)

1.2 (0.9–1.6, N = 692)

1.2 (0.9–1.4, N = 348)

Leukocytes, 109/L

9.7 (7.2–12.8, N = 1071)

10.5 (7.9–13.9, N = 743)

12.2 (9.7–15.5, N = 373)

pH

7.37 (7.32–7.41, N = 1105)

7.41 (7.35–7.46, N = 742)

7.4 (7.33–7.46, N = 369)

Thrombocytes, 109/L

251 (189–325, N = 1093)

309 (225–397, N = 748)

383 (281–507, N = 376)

Respiratory parameters

   

Respiratory rate, /min

22 (20–26, N = 846)

24 (20–28, N = 618)

25 (22–28, N = 324)

FiO2, %

45 (40–55, N = 1124)

46 (40–58, N = 754)

45 (36–60, N = 382)

PEEP, cmH2O

12 (10–14, N = 1121)

12 (10–14, N = 758)

10 (8–13, N = 383)

Pressure control:

   

 Set pressure, cmH2O

12 (10–15, N = 816)

12 (8–16, N = 655)

12 (8–16, N = 346)

Volume control:

   

 Plat pressure, cmH2O

24 (21–27, N = 528)

25 (22–29, N = 481)

25 (21–29, N = 276)

Tidal volume, mL/kg PBW

6.6 (6.1–7.6, N = 1085)

6.8 (6.1–7.8, N = 729)

6.9 (6.1–8.0, N = 362)

Static compliancea, ml/cmH2O

38 (30–52, N = 911)

37 (28–57, N = 671)

37 (26–60, N = 341)

Driving pressure, cmH2O

12 (9–14, N = 937)

12 (8–16, N = 684)

13 (9–16, N = 352)

P/F-ratiob

167 (130–210, N = 1110)

152 (122–193, N = 756)

161 (120–203, N = 380)

Ventilatory ratioc

1.7 (1.3–2.2, N = 1046)

2.1 (1.7–2.7, N = 718)

2.3 (1.8–2.9, N = 357)

  1. Patient demographics, lab values and respiratory parameters are shown. All values represent the median with an interquartile range unless otherwise specified. The number of observations is included. Respiratory parameters and gas exchange indices were shown for patients in a controlled mode only
  2. Patient demographics did not change substantially between the different days on IMV
  3. PC pressure control, PWB predicted body weight, plat pressure plateau pressure, FiO2 fraction of inspired oxygen, PEEP positive end expiratory pressure, CRP C-reactive protein
  4. aThe recorded static respiratory system compliance or the tidal volume/(plateau pressure—PEEP)
  5. bGradient between PaO2 and FiO2
  6. cMinute volume * PCO2/(predicted body weight * 100 * 37.5)
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