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Fig. 1 | Intensive Care Medicine Experimental

Fig. 1

From: Pulmonary and intestinal microbiota dynamics during Gram-negative pneumonia-derived sepsis

Fig. 1

Organ bacterial loads and cytokine levels during K. pneumoniae infection. a Experimental design. Mice received an intranasal inoculation with 104 colony forming units (CFU) of K. pneumoniae. A group was killed every 6 h, until 36 h (n = 10–12) at which time blood, lung, tongue and feces were collected, t = 0 serves as the control group. This model becomes lethal approximately 40 h post-inoculation (a). Pulmonary (b) and blood (c) CFU at 0 to 36 h post-inoculation. Tumor necrosis factor (TNF) of lung homogenate (d) and blood plasma (e) at 0 to 36 h post-inoculation. Data are shown as median, the top bar denotes at which time-points the data are significantly different from the 0-h group, the stars show the range of significance, p < 0.01 (**), p < 0.001 (***) and p < 0.0001 (****)

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