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Intensive Care Medicine Experimental

Table 2 sORP cut-off values for hypovitaminosis C and vitamin C deficiency

From: Rapid screening of critically ill patients for low plasma vitamin C concentrations using a point-of-care oxidation–reduction potential measurement

 

Cut-off value, mV

Sensitivity, % (95% CI)

Specificity, % (95% CI)

PPV, %

(95% CI)

NPV, %

(95% CI)

AUC

(95% CI)

p-value

Both fresh and thawed samples (datasets combined)

 Hypovitaminosis C (prevalence: 60/122)

103.0

100 (94–100)

44 (31–57)

63 (53–73)

100 (87–100)

0.91 (0.86–0.96)

 < 0.001

 

114.6a

90 (80–96)

77 (65–87)

79 (68–88)

89 (77–96)

  
 

141.1

23 (13–36)

100 (94–100)

100 (77–100)

57 (48–67)

  

 Vitamin C deficiency (prevalence: 18/122)

119.6

100 (82–100)

70 (60–79)

37 (23–52)

100 (95–100)

0.93 (0.88–0.98)

 < 0.001

 

124.7a

94 (73–100)

79 (70–86)

44 (28–60)

99 (94–100)

  
 

146.9

33 (13–59)

100 (97–100)

100 (54–100)

90 (83–95)

  
  1. AUC area under the curve, CI confidence interval, NPV negative predictive value, PPV positive predictive value
  2. aOptimal cut-off value, as chosen using Youden’s J Statistic
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