Fig. 2

Comparison of progranulin (PGRN, A) and procalcitonin (PCT, B) plasma concentrations between healthy controls and patients with either a severe localized infection (e.g., a large peripheral abscess at high risk for sepsis), non-COVID-19 community-acquired pneumonia (CAP), sepsis or septic shock. Data are presented separately for the exploratory (blue boxplots) and the confirmatory study (orange boxplots). All symbols indicate p < 0.001. Significant p-values ≥ 0.001 are given as numbers in addition to symbols. # Indicates a significant difference between patients with sepsis, septic shock or CAP when compared to healthy controls. $ Indicates a significant difference between patients with sepsis, septic shock or healthy controls when compared to patients with CAP. + Indicates a significant difference between patients with sepsis, CAP or healthy controls when compared to septic shock patients