Skip to main content
Intensive Care Medicine Experimental
Fig. 4 | Intensive Care Medicine Experimental

Fig. 4

From: Interstitial washdown and vascular albumin refill during fluid infusion: novel kinetic analysis from three clinical trials

Fig. 4

Influence of interstitial washdown on the distribution of crystalloid fluid. Volume kinetic analysis of the fluid distribution when 1.7 L of Ringer’s was infused in volunteers (top row; subplots A–D), 1.7 L to patients undergoing surgery (middle row; subplots E–H) and 1.0 L of 0.9% saline was given to patients with ketoacidosis (bottom row; subplots I–L). All infusions were given over 30 min. All volumes are shown depending on whether the interstitial washdown was in the low or high range (minimal to maximum washdown; approximately 5–95% span). For the volunteers, the range was between − 0.10 and + 0.10 (mean − 0.019), for the anesthesia patients − 0.01 to + 0.15 (mean, + 0.05), and for the patients with ketoacidosis the Hb–albumin difference in plasma dilution varied from − 0.10 to + 0.40 (mean, + 0.046)

Back to article page