Table 1 Demographic data and volume kinetic analysis of the three series of crystalloid fluid infusions

Demographics

 Subjects/infusions (N)

25/25

30/30

17/31

 Females/males (N)

0/25

25/4

2/15

 Age (years)

32 ± 7

55 ± 16

50 ± 22

 Body weight (kg)

80 ± 9

69 ± 11

72 ± 11

 Hb at baseline (g/L)

135 ± 8

123 ± 11*

135 ± 25

Parameter base model

 k₁₂ (10^–3 min⁻¹)

34.0 ± 3.0

66.2 ± 7.7

83.3 ± 2.2

 k₂₁ (10^–3 min⁻¹)

12.4 ± 2.1

33.3 ± 4.5

79.4 ± 2.2

 k₁₀ (10^–3 min⁻¹)

11.8 ± 0.2

2.4 ± 0.5

13.2 ± 2.6

 k_b (10^–3 min⁻¹)

1.1 ± 0.1

5.4 ± 1.6

5.8 ± 2.6

Covariance

 k₁₂

6.7 ± 1.9

2.3 ± 0.7

None

 k₂₁

7.3 ± 4.9

2.7 ± 1.2

-0.9 ± 0.1

 k₁₀

− 4.2 ± 0.9

2.9 ± 1.4

-1.7 ± 0.8

 k_b

None

5.2 ± 2.8

-2.3 ± 0.3