Inflammatory markers assessment in an animal model of intracranial hypertension: a randomized trial

do Espírito Santo, Marcelo Prudente; Faria, Caroline Silvério; Solla, Davi Jorge Fontoura; Pipek, Leonardo Zumerkorn; Belon, Alessandro Rodrigo; Jeng, Brasil Ping; de Andrade, Almir Ferreira; Teixeira, Manoel Jacobsen; Paiva, Wellingson Silva

doi:10.1186/s40635-021-00408-5

Intensive Care Medicine Experimental

Table 1 Cytokines values along the experiment according to group and moment (n = 10 per group)

From: Inflammatory markers assessment in an animal model of intracranial hypertension: a randomized trial

Group	Cytokine	Moment			p values
Group	Cytokine	Baseline	Pre-insufflation	Pre-deflation	p values
IL-1α
4 ml	Median (quartiles)	0,04 (0,03–0,07)	0,05 (0,03–0,13)	0,07 (0,04–0,12)	Group, p = 0,617 Moment, p = 0,006 Interaction, p = 0,848
4 ml	Min; max	0,01; 0,14	0,03; 0,20	0,02; 0,17
7 ml	Median (quartiles)	0,04 (0,02–0,06)	0,05 (0,05–0,06)	0,05 (0,03–0,06)
7 ml	Min; max	0,01; 0,13	0,03; 0,19	0,02; 0,16
IL-1β
4 ml	Median (quartiles)	0,27 (0,20–0,44)	0,65 (0,37—1,18)	1,44 (0,51–2,49)	Group, p = 0,934 Moment, p = 0,014 Interaction, p = 0,889
4 ml	Min; max	0,11; 5,05	0,12; 9,74	0,11; 10,1
7 ml	Median (quartiles)	0,40 (0,20–0,55)	0,97 (0,39–1,39)	1,32 (0,59–2,80)
7 ml	Min; max	0,13; 1,85	0,31; 8,3	0,13; 6,06
IL-1ra
4 ml	Median (quartiles)	0,58 (0,37–1,07)	56,1 (24,7–73,3)	72,1 (54,9–84,7)	Group, p = 0,919 Moment, p < 0,001 Interaction, p = 0,996
4 ml	Min; max	0,3; 86,4	0,4; 101,4	2,1; 101,8
7 ml	Median (quartiles)	0,87 (0,31–2,52)	64,1 (51,7–76,7)	70,8 (49,4–87,6)
7 ml	Min; max	0,2; 70,6	0,5; 109,4	0,4; 94,9
IL-2
4 ml	Median (quartiles)	0,12 (0,06–0,17)	0,11 (0,07–0,16)	0,09 (0,05–0,16)	Group, p = 0,543 Moment, p = 0,022 Interaction, p = 0,327
4 ml	Min; max	0,02; 0,27	0,02; 0,30	0,02; 0,20
7 ml	Median (quartiles)	0,13 (0,07–0,19)	0,11 (0,06–0,14)	0,05 (0,04–0,08)
7 ml	Min; max	0,03; 0,25	0,04; 0,17	0,03; 0,16
IL-4
4 ml	Median (quartiles)	0,59 (0,32–0,89)	0,52 (0,44–0,82)	0,51 (0,32–0,85)	Group, p = 0,166 Moment, p = 0,015 Interaction, p = 0,397
4 ml	Min; max	0,16; 1,39	0,16; 1,29	0,16; 1,04
7 ml	Median (quartiles)	0,60 (0,36–0,78)	0,49 (0,35–0,68)	0,25 (0,23–0,41)
7 ml	Min; max	0,18; 1,20	0,18; 0,74	0,19; 0,74
IL-6
4 ml	Median (quartiles)	0,14 (0,11–0,43)	1,21 (0,20–3,12)	1,70 (0,22–5,20)	Group, p = 0,837 Moment, p = 0,010 Interaction, p = 0,922
4 ml	Min; max	0,03; 6,39	0,05; 6,04	0,04; 7,07
7 ml	Median (quartiles)	0,22 (0,11–0,89)	1,62 (0,49–2,18)	2,27 (0,37–3,24)
7 ml	Min; max	0,06; 1,03	0,12; 10,11	0,04; 5,86
IL-8
4 ml	Median (quartiles)	0,17 (0,08–0,30)	3,54 (0,22–14,8)	1,38 (0,20–39,57)	Group, p = 0,766 Moment, p = 0,257 Interaction, p = 0,679
4 ml	Min; max	0,04; 63,7	0,03; 40,3	0,04; 58,2
7 ml	Median (quartiles)	0,40 (0,16–1,07)	11,4 (0,82–19,5)	3,02 (0,89–21,85)
7 ml	Min; max	0,1; 16	0,2; 92,1	0,1; 42,9
IL-10
4 ml	Median (quartiles)	0,62 (0,41–1,02)	0,86 (0,70–1,41)	0,88 (0,65–1,02)	Group, p = 0,765 Moment, p = 0,203 Interaction, p = 0,505
4 ml	Min; max	0,18; 1,48	0,3; 1,67	0,24; 1,05
7 ml	Median (quartiles)	0,68 (0,49–1,06)	0,79 (0,69–1,08)	0,66 (0,46–0,81)
7 ml	Min; max	0,29; 1,85	0,53; 1,23	0,29; 1,34
IL-12
4 ml	Median (quartiles)	1,59 (1,18–1,85)	2,42 (1,10–3,19)	2,63 (1,34–3,24)	Group, p = 0,281 Moment, p < 0,001 Interaction, p = 0,793
4 ml	Min; max	0,9; 2,7	1; 4,4	0,9; 3,9
7 ml	Median (quartiles)	1,27 (0,96–1,49)	2,12 (1,16–2,40)	2,13 (1,40–2,46)
7 ml	Min; max	0,7; 1,7	0,8; 4,4	0,6; 3,3
IL-18
4 ml	Median (quartiles)	1,45 (1,23–2,46)	2,08 (1,16–4,06)	2,41 (1,35–4,11)	Group, p = 0,732 Moment, p = 0,002 Interaction, p = 0,913
4 ml	Min; max	0,7; 4	0,8; 6	0,6; 6,2
7 ml	Median (quartiles)	1,73 (1,23–2,44)	2,04 (1,76–3,38)	2,24 (1,14–2,76)
7 ml	Min; max	0,7; 3	3; 5,1	0,6; 5,5
TNF-a
4 ml	Median (quartiles)	0,99 (0,11–5,13)	2,21 (0,22–3,01)	0,67 (0,16–1,87)	Group, p = 0,747 Moment, p = 0,008 Interaction, p = 0,306
4 ml	Min; max	0,03; 17	0,02; 42,7	0,02; 7,9
7 ml	Median (quartiles)	1,95 (0,15–17,6)	2,59 (0,74–7,84)	0,77 (0,46–1,39)
7 ml	Min; max	0,1; 35,8	0,2; 17,1	0,2; 22,7

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