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Intensive Care Medicine Experimental
Fig. 2 | Intensive Care Medicine Experimental

Fig. 2

From: Plasma hyaluronan, hyaluronidase activity and endogenous hyaluronidase inhibition in sepsis: an experimental and clinical cohort study

Fig. 2

a–c Preclinical experiments. a Plasma hyaluronan, b effective plasma HYAL activity and c plasma HYAL inhibition for timepoint T0–6–12. a Plasma hyaluronan concentration increased over time in all groups (Control p = 0.046, Sepsis-1 and Sepsis-2 p = 0.043). b Effective plasma HYAL activity decreased during the experiment in all groups (Control p = 0.028, Sepsis-1 and Sepsis-2 p = 0.043) whereas c plasma HYAL inhibition increased significantly in Control and Sepsis-1 over time (Control p = 0.028, Sepsis-1 p = 0.043). Control (white), Sepsis-1 (light gray) and Sepsis-2 (dark gray). p-value from Mann–Whitney U test and Wilcoxon signed-rank test

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