| |
Model C
|
Model B
|
Model A
|
|---|
| |
Additional file 1: Fig S7
|
Additional file 1: Fig S8
|
Fig. 4
|
|---|
| | | | |
95%CI
|
|---|
|
Factora−i
| | | | |
|
b_Ps_n
| | | | |
|
Pseudomonas colonization
|
1.25***
|
1.23***
|
1.23***
|
0.86 to 1.59
|
|
ppap
|
0.76*
|
0.74*
|
0.73*
|
0.1 to 1.36
|
|
_cons
|
− 5.92***
|
− 5.79***
|
− 5.83***
|
− 6.37 to − 5.28
|
|
v_Ps_n
| | | | |
|
Pseudomonas colonization
|
1
|
1
|
1
|
(constrained)
|
|
mvp90
|
0.35
|
0.25
|
0.28
|
− 0.11 to 0.67
|
|
non_D
|
− 0.54***
|
− 0.52***
|
− 0.46***
|
− 0.71 to − 0.22
|
|
_cons
|
− 4.48***
|
− 4.22***
|
− 4.31***
|
− 5.01 to − 3.57
|
|
Pseudomonas colonization
| | | | |
|
cc
| | |
0.37*
|
0.06 to 0.68
|
|
tap
|
− 0.64***
|
− 0.49***
|
− 0.44***
|
− 0.68 to − 0.21
|
|
Anti-septic (a_S)
|
− 0.86***
|
− 0.44
|
− 0.44
|
− 0.94 to 0.06
|
|
los7
|
0.82***
|
0.69***
|
0.69***
|
0.38 to 0.99
|
|
Trauma (trauma50)
|
− 0.05
|
− 0.01
|
− 0.03
|
− 0.4 to 0.34
|
|
crf
|
0.20
|
− 0.29
|
− 0.38
|
− 0.95 to 0.19
|
|
Candida colonization
| |
0.39***
|
0.37***
|
0.26 to 0.49
|
|
b_can_n
| | | | |
|
Candida colonization
|
0.73***
|
0.7***
|
0.7***
|
0.33 to 1.07
|
|
_cons
|
− 5.01***
|
− 4.95***
|
− 4.97***
|
− 5.34 to − 4.6
|
|
v_can_n
| | | | |
|
Candida colonization
|
1
|
1
|
1
|
(constrained)
|
|
mvp90
|
− 0.77
|
− 0.56
|
− 0.54
|
− 1.4 to 0.31
|
|
non_D
|
− 0.22
|
− 0.31
|
− 0.25
|
− 0.84 to 0.33
|
|
_cons
|
− 3.65***
|
− 4.0***
|
− 4.05***
|
− 5.77 to − 2.36
|
|
Candida colonization
| | | | |
|
cc
| | |
0.45
|
− 0.19 to 1.09
|
|
tap
|
0.96*
|
0.96*
|
1.02*
|
0.11 to 1.93
|
|
Anti-septic (a_S)
|
− 1.28**
|
− 1.27**
|
− 1.23**
|
− 2.13 to − 0.32
|
|
los7
|
0.13
|
0.13
|
0.1
|
− 0.45 to 0.65
|
|
Trauma (trauma50)
|
0.11
|
0.02
|
0.03
|
− 0.87 to 0.82
|
|
crf
|
1.43**
|
1.51**
|
1.48**
|
0.45 to 2.5
|
|
Amphotericin
|
− 1.73**
|
− 1.77***
|
− 1.78***
|
− 2.79 to − 0.78
|
|
Nystatin
|
− 0.90
|
− 1.05
|
− 1.04
|
− 2.33 to 0.3
|
|
Azoles and other
|
− 1.44**
|
− 1.53**
|
− 1.47**
|
− 2.56 to − 0.38
|
|
Error terms
| | | | |
|
var (e. Pseudomonas col)
|
0.52***
|
0.33***
|
0.32***
|
0.23 to 0.44
|
|
var (e. Candida col)
|
1.37***
|
1.3***
|
1.27***
|
0.82 to 1.97
|
|
Model fiti
| | | | |
|
AIC
|
3974
|
3928
|
3921
|
–
|
|
Groups (n)
|
464
|
464
|
464
|
–
|
|
Clusters (n)
|
279
|
279
|
279
| |
|
Factors (N)
|
29
|
30
|
32
|
–
|
- Shown in this table are models derived with all studies increasing in complexity from left to right. The figures corresponding to models C (Additional file 1: Fig. S7), model B (Additional file 1: Fig. S8) models A (Fig. 4)
- *p < 0.05; **p < 0.01; ***p < 0.001
- av_ps_n is the count of Pseudomonas VAP; v_can_n is the count of RT Candida; b_ps_n is the count of Pseudomonas bacteremia and b_can_n is the count of Candidemia
- bppap is the group wide use of protocolized parenteral antibiotic prophylaxis; tap is topical antibiotic prophylaxis; non-D is a non-decontamination intervention
- cmvp90 is use of mechanical ventilation by more than 90% of the group
- dcrf is group wide exposure to a candidemia risk factor
- eLOS7 is a mean or median length of ICU stay for the group of more than 7 days
- fTrauma ICU arbitrarily defined as an ICU for which > 50% of admissions were for trauma
- gPseudomonas colonization (Pseudomonas col) is a latent variable
- hCandida colonization (Candida col) is a latent variable
- iModel fit; AIC is Akaike’s information criteria. This indicates model fit taking into account the statistical goodness of fit and the number of parameters in the model. Lower values of AIC indicate a better model fit. Groups (n) is the number of patient groups; clusters (n) is the number of studies; factors (N) is the number of parameters in the model
