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Intensive Care Medicine Experimental

Table 2 Development of GSEM models; model C, model B and model A

From: Structural equation modelling the relationship between anti-fungal prophylaxis and Pseudomonas bacteremia in ICU patients

 

Model C

Model B

Model A

 

Additional file 1: Fig S7

Additional file 1: Fig S8

Fig. 4

    

95%CI

Factora−i

    

b_Ps_n

    

 Pseudomonas colonization

1.25***

1.23***

1.23***

0.86 to 1.59

 ppap

0.76*

0.74*

0.73*

0.1 to 1.36

 _cons

− 5.92***

− 5.79***

− 5.83***

− 6.37 to − 5.28

v_Ps_n

    

 Pseudomonas colonization

1

1

1

(constrained)

 mvp90

0.35

0.25

0.28

− 0.11 to 0.67

 non_D

− 0.54***

− 0.52***

− 0.46***

− 0.71 to − 0.22

 _cons

− 4.48***

− 4.22***

− 4.31***

− 5.01 to − 3.57

Pseudomonas colonization

    

cc

  

0.37*

0.06 to 0.68

tap

− 0.64***

− 0.49***

− 0.44***

− 0.68 to − 0.21

Anti-septic (a_S)

− 0.86***

− 0.44

− 0.44

− 0.94 to 0.06

los7

0.82***

0.69***

0.69***

0.38 to 0.99

Trauma (trauma50)

− 0.05

− 0.01

− 0.03

− 0.4 to 0.34

crf

0.20

− 0.29

− 0.38

− 0.95 to 0.19

Candida colonization

 

0.39***

0.37***

0.26 to 0.49

b_can_n

    

 Candida colonization

0.73***

0.7***

0.7***

0.33 to 1.07

 _cons

− 5.01***

− 4.95***

− 4.97***

− 5.34 to − 4.6

v_can_n

    

 Candida colonization

1

1

1

(constrained)

 mvp90

− 0.77

− 0.56

− 0.54

− 1.4 to 0.31

non_D

− 0.22

− 0.31

− 0.25

− 0.84 to 0.33

_cons

− 3.65***

− 4.0***

− 4.05***

− 5.77 to − 2.36

Candida colonization

    

cc

  

0.45

− 0.19 to 1.09

tap

0.96*

0.96*

1.02*

0.11 to 1.93

Anti-septic (a_S)

− 1.28**

− 1.27**

− 1.23**

− 2.13 to − 0.32

los7

0.13

0.13

0.1

− 0.45 to 0.65

Trauma (trauma50)

0.11

0.02

0.03

− 0.87 to 0.82

crf

1.43**

1.51**

1.48**

0.45 to 2.5

Amphotericin

− 1.73**

− 1.77***

− 1.78***

− 2.79 to − 0.78

Nystatin

− 0.90

− 1.05

− 1.04

− 2.33 to 0.3

Azoles and other

− 1.44**

− 1.53**

− 1.47**

− 2.56 to − 0.38

Error terms

    

var (e. Pseudomonas col)

0.52***

0.33***

0.32***

0.23 to 0.44

var (e. Candida col)

1.37***

1.3***

1.27***

0.82 to 1.97

Model fiti

    

AIC

3974

3928

3921

–

Groups (n)

464

464

464

–

Clusters (n)

279

279

279

 

Factors (N)

29

30

32

–

  1. Shown in this table are models derived with all studies increasing in complexity from left to right. The figures corresponding to models C (Additional file 1: Fig. S7), model B (Additional file 1: Fig. S8) models A (Fig. 4)
  2. *p < 0.05; **p < 0.01; ***p < 0.001
  3. av_ps_n is the count of Pseudomonas VAP; v_can_n is the count of RT Candida; b_ps_n is the count of Pseudomonas bacteremia and b_can_n is the count of Candidemia
  4. bppap is the group wide use of protocolized parenteral antibiotic prophylaxis; tap is topical antibiotic prophylaxis; non-D is a non-decontamination intervention
  5. cmvp90 is use of mechanical ventilation by more than 90% of the group
  6. dcrf is group wide exposure to a candidemia risk factor
  7. eLOS7 is a mean or median length of ICU stay for the group of more than 7 days
  8. fTrauma ICU arbitrarily defined as an ICU for which > 50% of admissions were for trauma
  9. gPseudomonas colonization (Pseudomonas col) is a latent variable
  10. hCandida colonization (Candida col) is a latent variable
  11. iModel fit; AIC is Akaike’s information criteria. This indicates model fit taking into account the statistical goodness of fit and the number of parameters in the model. Lower values of AIC indicate a better model fit. Groups (n) is the number of patient groups; clusters (n) is the number of studies; factors (N) is the number of parameters in the model
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