Skip to main content

Table 1 Characteristics of healthy subjects and patients

From: High levels of monocytic myeloid-derived suppressor cells are associated with favorable outcome in patients with pneumonia and sepsis with multi-organ failure

Characteristic

Healthy controls

Survivors (90 days)

Non-survivors (90 days)

p value* (survivors vs non-survivors)

Number of patients

18

14

34

 

Gender, male

15 (83%)

11 (79%)

24 (71%)

 

Age (years)

53 [25–58]

57 [47–74]

75 [67–86]

0.0014

Type of infection

   

 VAP/HAP

11 (79%)

22 (65%)

0.35

 HCAP

3 (21%)

12 (35%)

 

Severity of illness at admission

    

 APACHE II score

16 [14–21]

23 [18–27]

0.009

 SOFA score

10 [8.8–11]

10 [9–12]

0.41

Secondary infections

9 (64%)

17 (50%)

0.36

New sepsis episode

7 (50%)

16 (47%)

0.85

Charlson comorbidity index

4 [1–5]

6 [5–9]

0.002

Length of hospital stay

36 [24–48]

14 [8–28]

0.003

Length of ICU stay

26 [13–37]

15 [8–28]

0.16

Leukocytes (× 109/L)

13.9 [7.5–16.0]

13.8 [10.6–20.4]

0.32

PMN-MDSCs (% of leukocytes)

2.1 [0.74–3.1]

22 [6–44]

22 [8–37]

0.96

M-MDSCs (% of leukocytes)

0.96 [0.46–1.5]

4.6 [2.6–6.5]

2.9 [1.8–4.1]

0.052

Lactate (mmol/L)

1.4 [0.85–2.2]

2.8 [1.6–2.8]

0.02

CRP (mg/L)

130 [40–174]

144 [78–184]

0.63

IL-6 (pg/mL)

29 [19–52]

31 [17–73]

0.73

Ferritin (ng/mL)

501 [349–675]

748 [437–1478]

0.14

  1. p values < 0.05 are highlighted in bold
  2. Data are medians [IQR] or n (%). Severity scores, leukocyte counts, MDSC levels and lactate levels were measured at study inclusion
  3. VAP ventilator-associated pneumonia, HAP hospital-acquired pneumonia, HCAP healthcare-associated pneumonia, PMN-MDSCs polymorphonuclear-MDSCs, M-MDSCs monocytic myeloid-derived suppressor cells
  4. *p values comparing survivors and non-survivors at 90 days