|
Interval
|
Control
|
NE
|
Control vs. NE group p value
|
|---|
|
Baseline (− 60)–0 min
| | | |
|
MAP (mmHg)
|
88 (78–98)
|
78 (72–95)
|
0.198
|
|
HR (bpm)
|
56 (55–87)
|
87 (74–103)
|
0.016*
|
|
PbtO2 (mmHg)
|
22 (8–70)
|
37 (30–40)
|
0.880
|
|
PaO2 (kPa)
|
53 (49–57)
|
37 (36–40)
|
0.001*
|
|
PaCO2 (kPa)
|
5.6 (5.4–6)
|
6.4 (5.9–6.7)
|
< 0.001*
|
|
b-Hemoglobin (mM/L)
|
5.8 (5.6–6.3)
|
5 (4.8–5.3)
|
< 0.001*
|
|
b-Glucose (mM/L)
|
4.1 (3.7–6)
|
5.8 (3.9–8.1)
|
0.180
|
|
b-Lactate (mM/L) ABG
|
0.9 (0.5–1)
|
0.5 (0.4–0.9)
|
0.753
|
|
b-pH ABG
|
7.45 (7.44–7.48)
|
7.46 (7.43–7.5)
|
0.951
|
|
Diuresis (mL)
|
25 (0–72.5)
|
0 (0–50)
|
0.274
|
|
Hypoperfusion 0–90 min
| | | |
|
MAP (mmHg)
|
41 (40–42)
|
80 (75–86)
|
< 0.001*
|
|
HR (bpm)
|
108 (63–180)
|
98 (85–115)
|
0.625
|
|
PbtO2 (mmHg)
|
8 (4–18)
|
28 (23–34)
|
0.160
|
|
PaO2 (kPa)
|
52 (46.6–53.9)
|
38 (35–41)
|
0.019
|
|
PaCO2 (kPa)
|
5.5 (5.2–6.3)
|
6.3 (6.1–6.7)
|
0.031*
|
|
b-Hemoglobin (mM/L)
|
5.7 (5–6.1)
|
5.1 (4.8–5.6)
|
0.189
|
|
b-Glucose (mM/L) MD
|
6 (3.8–7.0)
|
4.9 (4.2–7.0)
|
0.974
|
|
b-Lactate (mM/L) ABG
|
8.2 (2.7–13.7)
|
1.1 (0.9–1.7)
|
0.001*
|
|
b-pH ABG
|
7.39 (7.23–7.4)
|
7.46 (7.43–7.49)
|
0.013
|
|
Diuresis (mL)
|
0 (0.35)
|
11.5 (0–47.5)
|
0.380
|
|
Post resuscitation 180–240 min
| | | |
|
MAP (mmHg)
|
56 (47–79)
|
74 (69–80)
|
0.037
|
|
HR (bpm)
|
89 (76–107)
|
90 (76–99)
|
0.858
|
|
PbtO2 (mmHg)
|
7 (2–10)
|
29 (13–34)
|
0.021
|
|
PaO2 (kPa)
|
51(49–54)
|
38 (37–42)
|
< 0.001*
|
|
PaCO2 (kPa)
|
6.5 (5.3–6.8)
|
6 (5.7–6.5)
|
0.665
|
|
b-Hemoglobin (mM/L)
|
6.5 (6–6.7)
|
4.6 (4.2–4.9)
|
< 0.001*
|
|
b-Glucose (mM/L)
|
2.8 (0.7–3.2)
|
3.6 (2.9–4.3)
|
0.432
|
|
b-Lactate (mM/L) ABG
|
3.9 (2–8.4)
|
0.5 (0.3–0.6)
|
0.003*
|
|
b-pH ABG
|
7.32 (7.29–7.39)
|
7.47 (7.45–7.51)
|
< 0.001*
|
|
Diuresis (mL)
|
0 (0–30)
|
0 (0–4)
|
0.676
|
- NE group n = 8, control group n = 4. Values are medians (interquartile range). Test statistics performed with mixed effect model
- *Statistical significant p value < 0.05
