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Table 2 Biochemical variables obtained on microdialysis from cerebral hemisphere

From: Effects of norepinephrine infusion on cerebral energy metabolism during experimental haemorrhagic shock

Baseline Location Control NE Control vs. NE group p value
LP ratio Hemisph 20 (15–29) 23 (18–27) 0.834
Lactate (mM/L) Hemisph 2.2 (1.4–3.8) 2.1 (1.7–3.1) 0.670
Pyruvate (mM/L) Hemisph 100 (92–134) 92 (73–108) 0.643
Glucose (mM/L) Hemisph 2.5 (1.8–2.8) 2.6 (2.2–3.2) 0.183
Glutamate (µM/L) Hemisph 15 (9–72) 12 (4–20) 0.081
Glycerol (µM/L) Hemisph 93 (58–149) 62 (45–90) 0.106
Hypoperfusion Location Control NE Control vs. NE group p value
LP ratio Hemisph 66 (38–82) 24 (19–31)  < 0.001*
Lactate (mM/L) Hemisph 7.8 (6.2–12.3) 2.5 (2.1–3.6)  < 0.001*
Pyruvate (mM/L) Hemisph 104 (81–177) 112 (91–132) 0.670
Glucose (mM/L) Hemisph 1 (0.4–1.6) 2.9 (2.4–3.9)  < 0.001*
Glutamate (µM/L) Hemisph 93 (6–155) 8 (4–11) 0.001*
Glycerol (µM/L) Hemisph 190 (75–270) 59 (44–86)  < 0.001*
Post resuscitation Location Control NE Control vs. NE group p value
LP ratio Hemisph 73 (29–100) 25 (21–29) 0.013*
Lactate (mM/L) Hemisph 4.9 (1–6.5) 1.3 (0.8–1.6)  < 0.001*
Pyruvate (mM/L) Hemisph 102 (71–185) 108 (100–133) 0.972
Glucose (mM/L) Hemisph 0.7 (0.5–0.8) 2.3 (1.6–2.9) 0.003*
Glutamate (µM/L) Hemisph 47 (6–110) 4 (2–7) 0.005*
Glycerol (µM/L) Hemisph 461 (254–545) 42 (23–55)  < 0.001*
  1. Values are divided into three-time intervals and expressed as median (interquartile range). Control n = 4. NE group n = 8. Test statistics performed with mixed effectt model
  2. *Statistical significant p value < 0.05