Skip to main content

Table 2 Biochemical variables obtained on microdialysis from cerebral hemisphere

From: Effects of norepinephrine infusion on cerebral energy metabolism during experimental haemorrhagic shock

Baseline

Location

Control

NE

Control vs. NE group p value

LP ratio

Hemisph

20 (15–29)

23 (18–27)

0.834

Lactate (mM/L)

Hemisph

2.2 (1.4–3.8)

2.1 (1.7–3.1)

0.670

Pyruvate (mM/L)

Hemisph

100 (92–134)

92 (73–108)

0.643

Glucose (mM/L)

Hemisph

2.5 (1.8–2.8)

2.6 (2.2–3.2)

0.183

Glutamate (µM/L)

Hemisph

15 (9–72)

12 (4–20)

0.081

Glycerol (µM/L)

Hemisph

93 (58–149)

62 (45–90)

0.106

Hypoperfusion

Location

Control

NE

Control vs. NE group p value

LP ratio

Hemisph

66 (38–82)

24 (19–31)

 < 0.001*

Lactate (mM/L)

Hemisph

7.8 (6.2–12.3)

2.5 (2.1–3.6)

 < 0.001*

Pyruvate (mM/L)

Hemisph

104 (81–177)

112 (91–132)

0.670

Glucose (mM/L)

Hemisph

1 (0.4–1.6)

2.9 (2.4–3.9)

 < 0.001*

Glutamate (µM/L)

Hemisph

93 (6–155)

8 (4–11)

0.001*

Glycerol (µM/L)

Hemisph

190 (75–270)

59 (44–86)

 < 0.001*

Post resuscitation

Location

Control

NE

Control vs. NE group p value

LP ratio

Hemisph

73 (29–100)

25 (21–29)

0.013*

Lactate (mM/L)

Hemisph

4.9 (1–6.5)

1.3 (0.8–1.6)

 < 0.001*

Pyruvate (mM/L)

Hemisph

102 (71–185)

108 (100–133)

0.972

Glucose (mM/L)

Hemisph

0.7 (0.5–0.8)

2.3 (1.6–2.9)

0.003*

Glutamate (µM/L)

Hemisph

47 (6–110)

4 (2–7)

0.005*

Glycerol (µM/L)

Hemisph

461 (254–545)

42 (23–55)

 < 0.001*

  1. Values are divided into three-time intervals and expressed as median (interquartile range). Control n = 4. NE group n = 8. Test statistics performed with mixed effectt model
  2. *Statistical significant p value < 0.05