Table 2 Comparison between stages 8 (S8), 9 (S9) and 10 (S10), that is, variables with and without ECMO support after lung lavage
S8: After surfactant depletion ECMO + Gas Flow OFF | S9: After surfactant depletion ECMO + Gas Flow ON | S10:After surfactant depletion ECMO + Gas Flow OFF | P value | |
|---|---|---|---|---|
Respiratory variables | ||||
Respiratory rate (ipm) | 35 [35, 35] | 35 [35, 35] | 35 [35, 35] | 1.000 |
Tidal volume (ml) | 160 [145, 173] | 150 [134, 173] | 147 [144, 178] | 0.031 |
Plato pressure (cmH2O) | 23 [20, 26] | 24 [21, 26] | 23 [21,2 6] | 0.656 |
FiO2 (%) | 100 [100, 100] | 100 [100, 100] | 30 [30, 35] | 0.001 |
PEEP (cmH2O) | 0 [0, 0] | 0 [0, 0] | 0 [0, 0] | 1.000 |
PaO2 (mmHg) | 50.3 [48.7, 53.5] | 72.7 [67.9, 108.0] | 50.5 [36.2, 54.1] | 0.002 |
PaCO2 (mmHg) | 62.5 [40.0, 63.8] | 52.1 [40.9, 53.5] | 67.9 [52.3, 68] | 0.067 |
PvO2 (mmHg) | 34.5 [25.7, 34.9] | 63.8 [57.1, 65.3] | 27.7 [24, 31.9] | 0.001 |
SaO2 (%) | 71.7 [60.6,73] | 91.4 [89.6,96.1] | 66.6 [33.0,80.2] | 0.006 |
SvO2 (%) | 48 [47,50] | 81 [79,90] | 49 [41,63] | 0.002 |
Hemodynamic variables | ||||
Heart rate (bpm) | 151 [147, 154] | 123 [106, 128] | 155 [137, 175] | 0.051 |
MAP (mmHg) | 78 [76, 94] | 82 [75, 104] | 97 [77, 99] | 0.622 |
MPAP (mmHg) | 41 [41, 42] | 31 [27, 33] | 44 [42, 50] | 0.010 |
CVP (mmHg) | 10 [8, 12] | 14 [11, 17] | 15 [11, 16] | 0.010 |
Wedge pressure (mmHg) | 10 [8, 10] | 9 [9, 14] | 10 [8, 14] | 0.639 |
Cardiac Output (l/min) | 6.7 [6.2, 9.3] | 6,8 [4.9, 20] | 6.5 [6.5, 6.7] | 0.369 |
Metabolic variables | ||||
Temperature (oC) | 38 [37.2, 38.2] | 37.9 [37.0, 38.0] | 37.9 [36.9, 38] | 0.282 |
pHa | 7.22 [7.19, 7.25] | 7.17 [7.06, 7.19] | 7.16 [6.96, 7.19] | 0.171 |
BE | − 1.9 [− 8.6, − 1.8] | − 3.0 [− 17, − 1.7] | − 16.5 [− 18.5, − 1.6] | 0.295 |
Lactate (mg/dl) | 12 [11, 12] | 8 [8, 16] | 8 [7,23] | 0.445 |
Hemoglobin (mg/dl) | 10 [8.5, 10.1] | 8.6 [7.6, 10] | 9.2 [8.4, 10.1] | 0.084 |