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Table 2 Comparison between stages 8 (S8), 9 (S9) and 10 (S10), that is, variables with and without ECMO support after lung lavage

From: Lung perfusion during veno-venous extracorporeal membrane oxygenation in a model of hypoxemic respiratory failure

  S8: After surfactant depletion
ECMO + Gas Flow OFF
S9: After surfactant depletion
ECMO + Gas Flow ON
S10:After surfactant depletion
ECMO + Gas Flow OFF
P value
Respiratory variables
Respiratory rate (ipm) 35 [35, 35] 35 [35, 35] 35 [35, 35] 1.000
Tidal volume (ml) 160 [145, 173] 150 [134, 173] 147 [144, 178] 0.031
Plato pressure (cmH2O) 23 [20, 26] 24 [21, 26] 23 [21,2 6] 0.656
FiO2 (%) 100 [100, 100] 100 [100, 100] 30 [30, 35] 0.001
PEEP (cmH2O) 0 [0, 0] 0 [0, 0] 0 [0, 0] 1.000
PaO2 (mmHg) 50.3 [48.7, 53.5] 72.7 [67.9, 108.0] 50.5 [36.2, 54.1] 0.002
PaCO2 (mmHg) 62.5 [40.0, 63.8] 52.1 [40.9, 53.5] 67.9 [52.3, 68] 0.067
PvO2 (mmHg) 34.5 [25.7, 34.9] 63.8 [57.1, 65.3] 27.7 [24, 31.9] 0.001
SaO2 (%) 71.7 [60.6,73] 91.4 [89.6,96.1] 66.6 [33.0,80.2] 0.006
SvO2 (%) 48 [47,50] 81 [79,90] 49 [41,63] 0.002
Hemodynamic variables
Heart rate (bpm) 151 [147, 154] 123 [106, 128] 155 [137, 175] 0.051
MAP (mmHg) 78 [76, 94] 82 [75, 104] 97 [77, 99] 0.622
MPAP (mmHg) 41 [41, 42] 31 [27, 33] 44 [42, 50] 0.010
CVP (mmHg) 10 [8, 12] 14 [11, 17] 15 [11, 16] 0.010
Wedge pressure (mmHg) 10 [8, 10] 9 [9, 14] 10 [8, 14] 0.639
Cardiac Output (l/min) 6.7 [6.2, 9.3] 6,8 [4.9, 20] 6.5 [6.5, 6.7] 0.369
Metabolic variables
Temperature (oC) 38 [37.2, 38.2] 37.9 [37.0, 38.0] 37.9 [36.9, 38] 0.282
pHa 7.22 [7.19, 7.25] 7.17 [7.06, 7.19] 7.16 [6.96, 7.19] 0.171
BE − 1.9 [− 8.6, − 1.8] − 3.0 [− 17, − 1.7] − 16.5 [− 18.5, − 1.6] 0.295
Lactate (mg/dl) 12 [11, 12] 8 [8, 16] 8 [7,23] 0.445
Hemoglobin (mg/dl) 10 [8.5, 10.1] 8.6 [7.6, 10] 9.2 [8.4, 10.1] 0.084
  1. SvO2 denotes venous oxygen saturation acquired in the Pulmonary Arterial Catheter; PaO2 and PvO2 denotes arterial and venous oxygen partial pressure, respectively; PaCO2 denotes arterial carbon dioxide partial pressure; SaO2 denotes arterial oxygen saturation; MAP denotes mean arterial pressure; MPAP denotes mean pulmonary arterial pressure; CVP denotes central venous pressure; and BE denotes Base Excess