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Table 2 Comparison of flow-controlled ventilation with volume-controlled ventilation

From: Flow-controlled ventilation in moderate acute respiratory distress syndrome due to COVID-19: an open-label repeated-measures controlled trial

 

FCV (n = 10)

VCV (n = 10)

p

95% CI of pseudo-medians

Effect size

PaO2 (mmHg)

74 [62–80]

73 [64–79]

0.65

− 4.5, 2.4

0.16

PaO2/FIO2 ratio (mmHg)

169 [125–195]

168 [132–194]

0.56

− 10.5, 3.6

0.21

FIO2

0.45 [0.40–0.49]

0.45 [0.40–0.49]

   

PEEP (cmH2O)

10 [10–12]

10 [10–12]

   

Pmean (cmH2O)

18 [15–20]

16 [13–17]

 < 0.01

1.5, 2.5

0.90

Pplat (cmH2O)

24 [20–25]

23 [19–26]

0.72

− 1.3, 2.0

0.10

Peak tracheal pressure (cmH2O)

26 [21–27]

 

0.03

− 5.0, − 0.5

0.71

Peak pressure at the ventilator (cmH2O)

 

28 [22–31]

MV (L/min)

6.60 [6.22–7.91]

7.85 [7.48–9.34]

0.01

− 1.9, − 0.5

0.81

TV (ml)

317 [281–360]

394 [344–410]

 < 0.01

− 79, − 24.8

0.85

Respiratory rate (min−1)

20 [20–24]

20 [20–24]

   

pH

7.31 [7.27–7.33]

7.31 [7.28–7.36]

0.24

− 0.05, 0.02

0.39

PaCO2 (mmHg)

53 [49–58]

48 [47–58]

0.31

− 2.5, 8.0

0.34

  1. Median [25th percentile–75th percentile]. Groups were compared with the paired Wilcoxon signed-rank test. P-values < 0.05 are marked in italics
  2. FCV flow-controlled ventilation, VCV volume-controlled ventilation, CI 95% confidence intervals of effect size, FIO2 fraction of inspiratory oxygen, PEEP positive end-expiratory pressure, Pmean mean airway pressure, Pplat plateau pressure, MV minute volume, TV tidal volume, RR respiratory rate, PaO2 partial pressure of arterial oxygen, PaCO2 partial pressure of arterial carbon dioxide