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Intensive Care Medicine Experimental
Fig. 6 | Intensive Care Medicine Experimental

Fig. 6

From: Sex-specific differences in cardiac function, inflammation and injury during early polymicrobial sepsis

Fig. 6

Expression of genes regulating cardioprotection and contractility after polymicrobial sepsis. A TNFR1/R2 ratio of mRNA expression in female and male wild-type mice before and 18 h after onset of sepsis (n = 6/sex). B Immunoblot for phosphotroponin I protein expression in left ventricle 18 h after sepsis in wild-type male and female mice (uncropped version in Additional file 1). Β-actin corrected values are compared in summary graph for 8/mice each sex. Individual p values on each panel refer to post hoc testing after ANOVA testing for sex x gene interaction. C mRNA expression of sarco(endo)plasmic reticulum Ca2 + ATPase 2 (SERCA2) female and male wild-type mice before and 18 h after onset of sepsis (n = 6/sex). Individual p values on each panel refer to post hoc testing after ANOVA testing for sex x condition interaction. D Immunoblot for SERCA2 protein expression in left ventricle 18 h after sepsis in wild-type male and female mice (original uncropped version in Additional file 1). Β-actin corrected values are compared in summary graph for 8/mice each sex. Individual p values on each panel refer to post hoc testing after ANOVA testing for sex x gene interaction

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