Fig. 7

Inflammatory response in iRHOM2-deficient female and male mice after polymicrobial sepsis. A Bone marrow and peritoneal enumeration of neutrophils before and after polymicrobial sepsis (n = 4–5 mice/sex, as indicated). Similar numbers of neutrophils egressed from bone marrow and accumulated in the peritoneum 18 h after onset of sepsis. B Intraperitoneal TNFα protein levels were higher in wild-type mice (n = 7; p = 0.026), compared with iRHOM2-deficient mice (n = 8), despite similar neutrophil infiltrates. C Surface CD62L expression in neutrophils obtained from wild-type and iRHOM2-deficient mice. This representative data show that CD62L surface expression declines in wild-type mice after sepsis, but fails to be shed from the neutrophil cell surface in iRHOM2-deficient mice (Additional file 1: Supplementary data for summary data)