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Fig. 8 | Intensive Care Medicine Experimental

Fig. 8

From: Sex-specific differences in cardiac function, inflammation and injury during early polymicrobial sepsis

Fig. 8

Loss of TNFα shedding in iRHOM2 deficiency and cardiac function after polymicrobial sepsis. A Summary data for stroke volume in male and female iRHOM2-deficient mice (n = 5/sex). Stroke volume increased only in both wild-type male mice. Data for each individual mouse were compared to its own pre-sepsis baseline reading, measured ~ 1 week before the onset of sepsis. Individual p values on each panel refer to post hoc testing after ANOVA testing for sex x time interaction. B Left ventricular volume (standardised by body weight) in iRHOM2-deficient male and female mice (n = 5/sex), as indicator of preload after 18 h sepsis. Data for each individual mouse were compared to its own pre-sepsis baseline reading, measured ~ 1 week before the onset of sepsis. Individual p values on each panel refer to post hoc testing after ANOVA testing for sex x time interaction. C Heart rate in male and female iRHOM2-deficient mice (n = 5/sex), as indicator of preload after 18 h sepsis. Data for each individual mouse were compared to its own pre-sepsis baseline reading, measured ~ 1 week before the onset of sepsis. Individual p values on each panel refer to post hoc testing after ANOVA testing for sex x time interaction

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