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Intensive Care Medicine Experimental
Fig. 1 | Intensive Care Medicine Experimental

Fig. 1

From: Induction of severe hypoxemia and low lung recruitability for the evaluation of therapeutic ventilation strategies: a translational model of combined surfactant-depletion and ventilator-induced lung injury

Fig. 1

Experimental protocol. Anesthetized pigs underwent lavage-induced surfactant depletion followed by either low (LVT; N = 6) or high (HVT; N = 6) tidal volume ventilation during ventilation phase 1 (3 h). LVT ventilation was resumed in ventilation phase 2 (3 h) in both groups. Recruitment maneuvers (RM) and PEEP trials were performed at three instances throughout the protocol to assess injury, recruitability, and “best PEEP”. For more details see “Methods” Section in the main text

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