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Intensive Care Medicine Experimental
Fig. 2 | Intensive Care Medicine Experimental

Fig. 2

From: Induction of severe hypoxemia and low lung recruitability for the evaluation of therapeutic ventilation strategies: a translational model of combined surfactant-depletion and ventilator-induced lung injury

Fig. 2

Respiratory mechanics and function. Dynamic compliance of the respiratory system (Crs) and arterial partial pressure of oxygenation (PaO2) were assessed in anesthetized pigs at baseline, after lavage-induced surfactant depletion, and after consecutive recruitment maneuvers (RM) at 3 h intervals. Group A, N = 6: continuous automated protective low tidal volume ventilation (LVT). Group B, N = 6: 3 h of injurious high tidal volume ventilation (HVT) prior to RM 2, resumption of protective low tidal volume ventilation for 3 h prior to RM 3. Two animals died after injurious HVT and RM 2, i.e., Group B, N = 4 at RM 3. For experimental protocol, see Fig. 1. Scatter plots with horizontal (means) and error bars (SD). **p < 0.01, Mann–Whitney U test

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