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Fig. 5 | Intensive Care Medicine Experimental

Fig. 5

From: Induction of severe hypoxemia and low lung recruitability for the evaluation of therapeutic ventilation strategies: a translational model of combined surfactant-depletion and ventilator-induced lung injury

Fig. 5

Tidal volume and mechanical power in combined lavage and ventilator-induced lung injury. Tidal volume (VT) and mechanical power (MP) of ventilation were assessed in anesthetized and surfactant-depleted pigs which underwent either an automated closed-loop protective low tidal volume (6 ml/kg BW LVT) and tabular PEEP ventilation strategy (group A) or non-automated injurious high tidal volume ventilation (HVT) with VT of 17 ml/kg BW and PEEP 2 cmH2O (group B) during ventilation phase 1. Ventilation phase 2 consisted of automated LVT ventilation in both groups (N = 6 each). Two animals died after injurious HVT and RM 2, i.e., Group B, N = 4 during ventilation phase 2. For experimental protocol, see Fig. 1 and “Methods” Section. For calculation of the MP, the simplified equation proposed by Becher et al. for pressure-controlled ventilation is used (see “Methods” Section in the main text). Means ± SD; p-values indicate significant group effects and were calculated using two-way ANOVA-type nparLD package (see Table 2, associated relative treatment effects (RTE) see Additional file 1: Table S2a). For more statistical details refer to main text

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