Skip to main content
Fig. 6 | Intensive Care Medicine Experimental

Fig. 6

From: Induction of severe hypoxemia and low lung recruitability for the evaluation of therapeutic ventilation strategies: a translational model of combined surfactant-depletion and ventilator-induced lung injury

Fig. 6

Histopathology. Representative tissue sections stained with hematoxylin/eosin of the right lower lung lobe of pigs after lavage-induced surfactant depletion and subsequent protective A, B or injurious C, D mechanical ventilation. High magnification fields (B, D, × 400) correspond to red box on low magnification field (A, C, × 100). Note the condensed histoarchitecture and signs of diffuse alveolar damage present after lavage and injurious ventilation (C, D), including septal thickening (*), massive interstitial ( →) and intra-alveolar ( >) infiltration of neutrophils, intra-alveolar erythrocytes (∆), protein strands (#), and disruption of the alveolar integrity ( +). In contrast, more aerated surface area with preserved alveolar architecture ( +), identification of type I pneumocytes (»), and less alveolar damage is present after lavage and protective ventilation (A, B). Septal thickening, neutrophil infiltration, and intra-alveolar protein strands occurred to a much lower extent

Back to article page