Fig. 5

Fluid volume kinetics. A Schematic drawing of the volume kinetic model. B Curve-fit in the final model for the plasma dilution versus time. C Correlation between the plasma MR-proANP concentration and the rate constant for urine flow (k₁₀). D Predicted versus measured plasma dilution in the final model. E Measured plasma dilution (red points) with the associated 5%, 50%, and 95% quantiles (black lines) and the corresponding quantiles obtained by a predictive check based on 1000 simulations using the model parameters in the final model (blue lines). F Inverse correlation between the urinary creatinine concentration at baseline and the rate constant for urine flow (k₁₀)