Table 1 Demographic and clinical characteristics of the participants in the 20% albumin infusion study
From: Fast versus slow infusion of 20% albumin: a randomized controlled cross-over trial in volunteers
Variable | Fast infusion | Slow infusion | p-value |
|---|---|---|---|
Plasma volume expansion (mL/kg) | |||
0.5 h | 5.4 ± 2.2 | 1.5 ± 1.6 | 0.001 |
2 h | 4.2 ± 2.6 | 4.9 ± 1.6 | 0.46 |
6 h | 2.5 ± 2.4 | 2.5 ± 2.5 | 0.92 |
AUC excess albumin (g min/kg) | |||
0–2 h | 50.3 (40.5–58.2) | 28.2 (24.8–31.8) | 0.003 |
Half-life albumin mass (h) | 8.0 (5.4–11.6) | 6.3 (4.4–8.4) | 0.028 |
AUC ∆plasma volume (L min/kg) | |||
0–2 h | 0.44 (0.40–0.65) | 0.26 (0.19–0.42) | 0.034 |
0–6 h | 1.08 (0.73–1.90) | 0.97 (0.67–1.68) | 0.31 |
Half-life plasma volume (h) | 5.6 (3.4–7.7) | 5.4 (2.0–10.1) | 0.347 |
Colloid osmotic pressure (mmHg), 0 min | 25.0 ± 1.0 | 25.1 ± 1.4 | 0.85 |
Recruited extravascular fluid (mL/mL)1 | 3.1 ± 1.3 | 3.1 ± 1.4 | 0.84 |
Mean arterial pressure (mmHg) | |||
0 h | 92 ± 11 | 93 ± 10 | 0.71 |
1 h | 90 ± 15 | 91 ± 8 | 0.73 |
2.5 h | 90 ± 12 | 91 ± 11 | 0.71 |
6 h | 94 ± 13 | 94 ± 10 | 0.96 |
Thrombocytes (109/L) | |||
0 h | 201 ± 50 | 190 ± 37 | 0.10 |
6 h | 193 ± 46 | 182 ± 41 | 0.02 |
Plasma sodium (mmol/L) | |||
0 h | 141.3 ± 2.0 | 141.0 ± 1.6 | 0.61 |
6 h | 142.1 ± 1.7 | 141.6 ± 1.8 | 0.36 |
Plasma potassium (mmol/L) | |||
0 h | 3.9 ± 0.3 | 3.9 ± 0.2 | 0.68 |
6 h | 3.9 ± 0.2 | 3.9 ± 0.2 | 0.55 |
Serum creatinine (µmol/L) | |||
0 h | 85 ± 14 | 85 ± 14 | 0.94 |
6 h | 78 ± 13 | 79 ± 14 | 0.54 |
Urinary creatinine (mmol/L) | |||
0 h | 15.1 ± 6.3 | 14.0 ± 4.5 | 0.30 |
6 h | 9.5 ± 5.9 | 9.9 ± 4.4 | 0.82 |