Fast versus slow infusion of 20% albumin: a randomized controlled cross-over trial in volunteers

Intensive Care Medicine Experimental

Table 2 Population kinetic parameters for infused albumin mass in the final model

Kinetic parameter	Covariate	Covariate model	Best estimate	95% CI	CV%	− 2 LL
Albumin kinetics
tvV_c (L)			5.89	5.16–6.62	6.3
tvk₁₀ (10^–4 min⁻⁴)			8.65	5.86–11.4	16.4	1213
k₁₀	Hgb baseline	Power	− 5.50	− 6.96 to − 4.04	− 13.5	1203
V_c	Albumin baseline	Power	4.32	1.60–7.03	31.9	1193
k₁₀	120-min infusion	Exponential	0.40	0.02–0.78	47.8	1187
Fluid kinetics
tvVc (L)			2.09	1.45–2.73	15.6
tvk₁₀ (10^–3 min⁻¹)	–		11.5	8.4–14.5	13.4
tvk₂₁ (10^–4 min⁻¹)	–		3.19	1.49–4.88	27.1	− 528
tvk_b (10^–3 min⁻¹)			12.5	3.90–21.0	35.0	− 582
k₂₁	∆ P-Albumin	Linear	0.083	0.057–0.108	16.0	− 609
k₁₀	MR-proANP	Power	0.80	0.37–1.23	28.7	− 624
k₁₀	U-creatinine, baseline	Exponential	− 0.96	− 1.80 to − 0.11	− 45.0	− 632

Shown are the typical values (tv) for the fixed parameters in the group, followed by individual-specific covariates
tv = typical value for the group. CI = confidence interval. CV% = coefficient of variation (inter-individual)
Mean blood Hgb at baseline 137 g/L and mean plasma albumin 40.0 g/L
LL = log likelihood for the model during development. Decrease by > 3.8 points = P < 0.05
Mean MR-proBNP = 49 pmol/L and urine creatinine 10.3 mmol/L