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  1. Authors: C Sánchez Ramirez, M Cabrera Santana, MA Hernández Viera, S Hípola Escalada, L Caipe Balcázar, N Sangil Monroy, A Bordes Benitez, F Artiles Campelo, P Saavedra Santana and S Ruiz Santana

    Citation: Intensive Care Medicine Experimental 2015 3(Suppl 1):A1009

    Content type: Poster presentation

    Published on:

    This article is part of a Supplement: Volume 3 Supplement 1

  2. Authors: M Chico-Fernández, M Sánchez-Casado, F Alberdi-Odriozola, F Guerrero-López, MD Mayor-García, J Egea-Guerrero, JF Fernández-Ortega, A Bueno-González, J González-Robledo, L Servià-Goixart, J Roldán-Ramírez, MÁ Ballesteros-Sanz, E Tejerina-Álvarez and JA Llompart-Pou

    Citation: Intensive Care Medicine Experimental 2015 3(Suppl 1):A856

    Content type: Poster presentation

    Published on:

    This article is part of a Supplement: Volume 3 Supplement 1

  3. Authors: E Coupez, J-F Timsit, A Boyer, L Bouadma, E Canet, K Klouche, L Argaud, J Bohé, M Garrouste-Orgeas, C Mariat, F Vincent, S Cayot, O Cointault, A Lepape, M Darmon, S Ruckly…

    Citation: Intensive Care Medicine Experimental 2015 3(Suppl 1):A463

    Content type: Poster presentation

    Published on:

    This article is part of a Supplement: Volume 3 Supplement 1

  4. Authors: M Miralbés Torner, F Ahmad Diaz, S Carvalho Brugger, SM Cano Marron, JA Schoenenberger, A Aragones Eroles, X Nuvials Casals, M Vallverdu Vidal, B Balsera Garrido and M Palomar Martinez

    Citation: Intensive Care Medicine Experimental 2015 3(Suppl 1):A394

    Content type: Poster presentation

    Published on:

    This article is part of a Supplement: Volume 3 Supplement 1

  5. Authors: J Ruiz Moreno, E González Marín, MJ Esteve Paños, R Corcuera Romero de la Devesa, M Moral Guiteras, M Juliá Amill, N Suárez Álvarez, N Conesa Folch, F Baigorri González and A Artigas Raventós

    Citation: Intensive Care Medicine Experimental 2015 3(Suppl 1):A247

    Content type: Poster presentation

    Published on:

    This article is part of a Supplement: Volume 3 Supplement 1

  6. Authors: C Sánchez Ramirez, L Caipe Balcázar, S Hípola Escalada, MA Hernández Viera, M Cabrera Santana, N Sangil Monroy, A Bordes Benitez, P Saavedra Santana and S Ruiz Santana

    Citation: Intensive Care Medicine Experimental 2015 3(Suppl 1):A2

    Content type: Oral presentation

    Published on:

    This article is part of a Supplement: Volume 3 Supplement 1

  7. Severe scorpion envenomation can evolve to lung injury and, in some cases, death. The lung injury could be attributed to acute left ventricular failure and increased pulmonary vascular permeability secondary t...

    Authors: Ceila Maria Sant Ana Malaque, Ana Carolina de Bragança, Talita Rojas Sanches, Rildo Aparecido Volpini, Maria Heloisa Shimizu, Meire Ioshie Hiyane, Niels Olsen Saraiva Câmara, Antonio Carlos Seguro and Lucia Andrade

    Citation: Intensive Care Medicine Experimental 2015 3:28

    Content type: Research

    Published on:

  8. Animal models are valuable in transfusion research. Use of human red blood cells (RBCs) in animal models facilitates extrapolation of the impact of storage conditions to the human condition but may be hampered...

    Authors: M. Straat, TRL Klei, D. de Korte, R. van Bruggen and NP Juffermans

    Citation: Intensive Care Medicine Experimental 2015 3:27

    Content type: Methodology

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  9. The diagnosis of ventilator-associated pneumonia (VAP) is challenging. An important aspect to improve outcome is early recognition of VAP and the initiation of the appropriate empirical treatment. We hypothesi...

    Authors: Ignacio Martin-Loeches, Lieuwe D. Bos, Pedro Povoa, Paula Ramirez, Marcus J. Schultz, Antoni Torres and Antonio Artigas

    Citation: Intensive Care Medicine Experimental 2015 3:26

    Content type: Research

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  10. Veno-arterial extracorporeal membrane oxygenation (ECMO-CPR) is a life-saving rescue for selected patients when standard cardiopulmonary resuscitation fails. The use is increasing although the treatment modali...

    Authors: Harald Arne Bergan, Per Steinar Halvorsen, Helge Skulstad, Thor Edvardsen, Erik Fosse and Jan Frederik Bugge

    Citation: Intensive Care Medicine Experimental 2015 3:25

    Content type: Research

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  11. Catheter securement is critical for the success of infusion therapy and to prevent complications. Our purpose was to compare the strength of catheter securement achieved with two investigational adhesive secur...

    Authors: Laura F. Rutledge, Daniel P. DeCabooter, Shelley-Ann H. Walters and Stéphanie F. Bernatchez

    Citation: Intensive Care Medicine Experimental 2015 3:24

    Content type: Methodology

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  12. Glucocorticoid (GC) treatment has variable effect in sepsis. This may be explained by decreased expression or function of the glucocorticoid receptor (GR). The aim of this study was to determine GR expression ...

    Authors: Maria Bergquist, Catharina Lindholm, Morten Strinnholm, Göran Hedenstierna and Christian Rylander

    Citation: Intensive Care Medicine Experimental 2015 3:23

    Content type: Research

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  13. Microvascular thrombosis during septic conditions is of essential clinical relevance, but the pathomechanisms are not yet completely understood. The purpose of this study was to study the distinguished differe...

    Authors: Heiko Sorg, Julius O. Hoffmann, Johannes N. Hoffmann and Brigitte Vollmar

    Citation: Intensive Care Medicine Experimental 2015 3:22

    Content type: Research

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  14. Renal ischemia/reperfusion (I/R) injury is commonly seen in kidney transplantation and affects the allograft survival rates. We aimed to test our hypothesis that scavenging reactive oxygen species (ROS) with t...

    Authors: Ugur Aksu, Bulent Ergin, Rick Bezemer, Asli Kandil, Dan M J Milstein, Cihan Demirci-Tansel and Can Ince

    Citation: Intensive Care Medicine Experimental 2015 3:21

    Content type: Research

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  15. Open AAA repair is associated with ischaemia-reperfusion injury where systemic inflammation and endothelial dysfunction can lead to multiple organ injury including acute lung injury. Oxidative stress plays a r...

    Authors: Martin J Duffy, Cecilia M O’Kane, Michael Stevenson, Ian S Young, Denis W Harkin, Brian A Mullan and Daniel F McAuley

    Citation: Intensive Care Medicine Experimental 2015 3:20

    Content type: Research

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  16. Survivors of critical illness are at increased risk of fractures. This may be due to increased osteoclast formation during critical illness, leading to trabecular bone loss. Such bone loss has also been observ...

    Authors: Helen C Owen, Ineke Vanhees, Jan Gunst, Sophie Van Cromphaut and Greet Van den Berghe

    Citation: Intensive Care Medicine Experimental 2015 3:19

    Content type: Research

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  17. Patients with acute respiratory distress syndrome receiving mechanical ventilation show inhomogeneous lung aeration. Atelectasis during uneven mechanical ventilation leads to alveolar hypoxia and could therefo...

    Authors: Kentaro Tojo, Yusuke Nagamine, Takuya Yazawa, Takahiro Mihara, Yasuko Baba, Shuhei Ota, Takahisa Goto and Kiyoyasu Kurahashi

    Citation: Intensive Care Medicine Experimental 2015 3:18

    Content type: Research

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  18. Prone position is used to recruit collapsed dependent lung regions during severe acute respiratory distress syndrome, improving lung elastance and lung gas content. We hypothesised that, in the absence of recr...

    Authors: Alessandro Santini, Alessandro Protti, Thomas Langer, Beatrice Comini, Massimo Monti, Cristina Carin Sparacino, Daniele Dondossola and Luciano Gattinoni

    Citation: Intensive Care Medicine Experimental 2015 3:17

    Content type: Research

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  19. Improperly set mechanical ventilation (MV) with normal lungs can advance lung injury and increase the incidence of acute respiratory distress syndrome (ARDS). A key mechanism of ventilator-induced lung injury ...

    Authors: Penny L Andrews, Benjamin Sadowitz, Michaela Kollisch-Singule, Joshua Satalin, Shreyas Roy, Kathy Snyder, Louis A Gatto, Gary F Nieman and Nader M Habashi

    Citation: Intensive Care Medicine Experimental 2015 3:16

    Content type: Research

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  20. Bone marrow-derived mesenchymal stem cells (BMSCs) reduced the severity of acute lung injury after transplantation in multiple experimental studies, and several paracrine soluble factors secreted by the cells ...

    Authors: Hiroyuki Ito, Tokujiro Uchida and Koshi Makita

    Citation: Intensive Care Medicine Experimental 2015 3:15

    Content type: Research

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  21. Microcirculation and macrohemodynamics are severely compromised during septic shock. However, the relationship between these two compartments needs to be further investigated. We hypothesized that early resusc...

    Authors: Alejandra López, Juan Carlos Grignola, Martín Angulo, Ignacio Alvez, Nicolás Nin, Gonzalo Lacuesta, Manuel Baz, Pablo Cardinal, Ivana Prestes, Juan P Bouchacourt, Juan Riva, Can Ince and Francisco Javier Hurtado

    Citation: Intensive Care Medicine Experimental 2015 3:14

    Content type: Research

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  22. The surge in uptake of nasal continuous positive airway pressure (CPAP) for respiratory support in preterm infants has occurred in the absence of an authentic animal model. Such a model would allow investigati...

    Authors: Peter A Dargaville, Anna Lavizzari, Priscila Padoin, Don Black, Elroy Zonneveld, Elizabeth Perkins, Magdy Sourial, Anushi E Rajapaksa, Peter G Davis, Stuart B Hooper, Timothy JM Moss, Graeme R Polglase and David G Tingay

    Citation: Intensive Care Medicine Experimental 2015 3:13

    Content type: Methodology

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  23. The mechanisms of sepsis mortality remain undefined. While there is some evidence of organ damage, it is not clear whether this damage alone is sufficient to cause death. Therefore, we aimed to examine contrib...

    Authors: Susanne Drechsler, Katrin M Weixelbaumer, Adelheid Weidinger, Pierre Raeven, Anna Khadem, Heinz Redl, Martijn van Griensven, Soheyl Bahrami, Daniel Remick, Andrey Kozlov and Marcin F Osuchowski

    Citation: Intensive Care Medicine Experimental 2015 3:12

    Content type: Research

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  24. The aim of the study was to describe the effects of intra-abdominal hypertension (IAH) on regional and microcirculatory intestinal blood flow, renal blood flow, and urine output, as well as their response to i...

    Authors: Gonzalo Ferrara, Vanina S Kanoore Edul, Juan F Caminos Eguillor, Enrique Martins, Carlos Canullán, Héctor S Canales, Can Ince, Elisa Estenssoro and Arnaldo Dubin

    Citation: Intensive Care Medicine Experimental 2015 3:11

    Content type: Research

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  25. Lethal and edema toxin contribute to shock and lethality with Bacillus anthracis. We showed previously in a 96-h sedated canine model that raxibacumab, a monoclonal antibody against protective antigen, augmented ...

    Authors: Kenneth E Remy, Xizhong Cui, Yan Li, Junfeng Sun, Steven B Solomon, Yvonne Fitz, Amisha V Barochia, Mariam Al-Hamad, Mahtab Moayeri, Stephen H Leppla and Peter Q Eichacker

    Citation: Intensive Care Medicine Experimental 2015 3:9

    Content type: Research

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  26. The renin-angiotensin system (RAS) plays a role in the pathogenesis of ARDS, Angiotensin II (Ang-II) contributing to the pathogenesis of inflammation and fibrogenesis. Angiotensin-(1-7) (Ang-(1-7)) may antagon...

    Authors: Vanessa Zambelli, Giacomo Bellani, Roberto Borsa, Federico Pozzi, Alice Grassi, Margherita Scanziani, Vittoria Castiglioni, Serge Masson, Alessandra Decio, John G Laffey, Roberto Latini and Antonio Pesenti

    Citation: Intensive Care Medicine Experimental 2015 3:8

    Content type: Research

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  27. The study of microglia and macrophage (M/M) morphology represents a key tool to understand the functional activation state and the pattern of distribution of these cells in acute brain injury. The identificati...

    Authors: Elisa R Zanier, Stefano Fumagalli, Carlo Perego, Francesca Pischiutta and Maria-Grazia De Simoni

    Citation: Intensive Care Medicine Experimental 2015 3:7

    Content type: Methodology

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  28. Systolic left ventricular function during therapeutic hypothermia is found both to improve and to decline. We hypothesized that this discrepancy would depend on the heart rate and the variables used to assess ...

    Authors: Viesturs Kerans, Andreas Espinoza, Helge Skulstad, Per Steinar Halvorsen, Thor Edvardsen and Jan Frederik Bugge

    Citation: Intensive Care Medicine Experimental 2015 3:6

    Content type: Research

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  29. Impaired coagulation contributes to the morbidity and mortality associated with septic shock. Whether abnormal platelet contraction adds to the bleeding tendency is unknown. Platelets contract when Ca2+-dependent...

    Authors: Benjamin AJ Reddi, Samantha M Iannella, Stephanie N O’Connor, Adam M Deane, Scott R Willoughby and David P Wilson

    Citation: Intensive Care Medicine Experimental 2015 3:5

    Content type: Research

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  30. Orthogonal polarized spectral (OPS) and sidestream dark field (SDF) imaging video microscope devices were introduced for observation of the microcirculation but, due to technical limitations, have remained as ...

    Authors: Guclu Aykut, Gerke Veenstra, Claudia Scorcella, Can Ince and Christiaan Boerma

    Citation: Intensive Care Medicine Experimental 2015 3:4

    Content type: Research

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  31. Lung failure after acute lung injury remains a challenge in different clinical settings. Various interventions for restoration of gas exchange have been investigated. Recruitment of collapsed alveoli by positi...

    Authors: Klaus Pfurtscheller, Stefan Ring, Elisabeth Beran, Erich Sorantin, Joachim Zobel, David Ganster, Alexander Avian and Gerfried Zobel

    Citation: Intensive Care Medicine Experimental 2015 3:3

    Content type: Research

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  32. Sepsis is characterised by diminished vasopressor responsiveness. Vasoconstriction depends upon a balance: Ca2+-dependent myosin light-chain kinase promotes and Ca2+-independent myosin light-chain phosphatase (ML...

    Authors: Benjamin AJ Reddi, John F Beltrame, Richard L Young and David P Wilson

    Citation: Intensive Care Medicine Experimental 2015 3:2

    Content type: Research

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  33. Sepsis has been shown to precondition the intact heart against ischaemia/reperfusion (IR) injury, and prior endotoxin exposure of cells in in vitro models has shown evidence of protection against subsequent simul...

    Authors: Criona M Walshe, John G Laffey, Leo Kevin and Daniel O’Toole

    Citation: Intensive Care Medicine Experimental 2015 3:1

    Content type: Research

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  34. Decreased renal blood flow (RBF) and vasoconstriction are considered major mechanisms of contrast-induced acute kidney injury (CIAKI). To understand the severity and duration of such putative effects, we measu...

    Authors: Paolo Calzavacca, Ken Ishikawa, Michael Bailey, Clive N May and Rinaldo Bellomo

    Citation: Intensive Care Medicine Experimental 2014 2:32

    Content type: Research

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  35. Up to 50% of septic patients develop acute kidney injury (AKI). The pathomechanism of septic AKI is poorly understood. Therefore, we established an innovative rodent model to characterize sepsis-induced AKI by...

    Authors: Martin A Schick, Wolfgang Baar, Sven Flemming, Nicolas Schlegel, Jakob Wollborn, Christopher Held, Reinhard Schneider, Robert W Brock, Norbert Roewer and Christian Wunder

    Citation: Intensive Care Medicine Experimental 2014 2:34

    Content type: Research

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  36. Lung weight characterises severity of pulmonary oedema and predicts response to mechanical ventilation. The aim of this study was to evaluate the accuracy of quantitative analysis of thorax computed tomography...

    Authors: Alessandro Protti, Giacomo E Iapichino, Marta Milesi, Valentina Melis, Paola Pugni, Beatrice Comini, Massimo Cressoni and Luciano Gattinoni

    Citation: Intensive Care Medicine Experimental 2014 2:31

    Content type: Research

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