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  1. Content type: Research

    The design of clinical immunology studies in sepsis presents several fundamental challenges to improving the translational understanding of pathologic mechanisms. We undertook a systematic review of bed-to-ben...

    Authors: David J Cain, Ana Gutierrez del Arroyo and Gareth L Ackland

    Citation: Intensive Care Medicine Experimental 2014 2:6

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  2. Content type: Research

    The loss of alveolar epithelial and endothelial integrity is a central component in acute respiratory distress syndrome (ARDS); however, experimental models investigating the mechanisms of epithelial injury ar...

    Authors: William R Henderson, Julian Barnbrook, Paolo B Dominelli, Donald EG Griesdale, Tara Arndt, Yannick Molgat-Seon, Glen Foster, Gareth L Ackland, James Xu, Najib T Ayas and Andrew W Sheel

    Citation: Intensive Care Medicine Experimental 2014 2:5

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  3. Content type: Research

    Heliox has a lower density and higher diffusion capacity compared to oxygen-in-air. We hypothesized that heliox ventilation allows for a reduction in minute volume ventilation and inspiratory pressures needed ...

    Authors: Charlotte J Beurskens, Hamid Aslami, Friso M de Beer, Joris JTH Roelofs, Margreeth B Vroom and Nicole P Juffermans

    Citation: Intensive Care Medicine Experimental 2014 2:8

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  4. Content type: Methodology

    Echocardiography plays a fundamental role in cannulae insertion and positioning for extracorporeal membrane oxygenation (ECMO). Optimal access and return cannulae orientation is required to prevent recirculati...

    Authors: David G Platts, Andrew Hilton, Sara Diab, Charles McDonald, Matthew Tunbridge, Saul Chemonges, Kimble R Dunster, Kiran Shekar, Darryl J Burstow and John F Fraser

    Citation: Intensive Care Medicine Experimental 2014 2:2

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  5. Content type: Research

    Ventilated patients with asymmetry of lung or chest wall mechanics may be vulnerable to differing lung stresses or strains dependent on body position. Our purpose was to examine transpulmonary pressure (PTP) and ...

    Authors: Gustavo A Cortes-Puentes, Kenneth Gard, Joseph C Keenan, Alexander Adams, David Dries and John J Marini

    Citation: Intensive Care Medicine Experimental 2014 2:4

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  6. Content type: Research

    In un-resuscitated rodent models of septic shock, the peroxisome proliferator-activated receptor-β/δ (PPAR-β/δ) agonist GW0742 improved visceral organ function. Therefore, we tested the hypothesis whether GW07...

    Authors: Martin Wepler, Sebastian Hafner, Angelika Scheuerle, Matthias Reize, Michael Gröger, Florian Wagner, Florian Simon, José Matallo, Frank Gottschalch, Andrea Seifritz, Bettina Stahl, Martin Matejovic, Amar Kapoor, Peter Möller, Enrico Calzia, Michael Georgieff…

    Citation: Intensive Care Medicine Experimental 2013 1:9

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  7. Content type: Research

    Mechanical ventilation can cause ventilator-induced lung injury, characterized by a sterile inflammatory response in the lungs resulting in tissue damage and respiratory failure. The cytokine interleukin-1β (I...

    Authors: Kim Timmermans, Selina EI van der Wal, Michiel Vaneker, Jeroen AWM van der Laak, Mihai G Netea, Peter Pickkers, Gert Jan Scheffer, Leo AB Joosten and Matthijs Kox

    Citation: Intensive Care Medicine Experimental 2013 1:8

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  8. Content type: Research

    Rodent models of sepsis are frequently used to investigate pathophysiological mechanisms and to evaluate putative therapeutic strategies. However, preclinical efficacy in these models has failed to translate t...

    Authors: Parjam S Zolfaghari, Bernardo Bollen Pinto, Alex Dyson and Mervyn Singer

    Citation: Intensive Care Medicine Experimental 2013 1:6

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  9. Content type: Research

    We aimed to test whether continuous recombinant human activated protein C (APC) administration would be able to protect renal oxygenation and function during endotoxemia in order to provide more insight into t...

    Authors: Emre Almac, Tanja Johannes, Rick Bezemer, Egbert G Mik, Klaus E Unertl, AB Johan Groeneveld and Can Ince

    Citation: Intensive Care Medicine Experimental 2013 1:5

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  10. Content type: Research

    This study aims to test the hypothesis that fluid loading with sodium chloride (150 mmol Na and 150 mmol Cl) or sodium octanoate (150 mmol Na, 100 mmol Cl, and 50 mmol octanoate) would lead to different acid–b...

    Authors: Lu Ke, Paolo Calzavacca, Michael Bailey, Wei-qin Li, Rinaldo Bellomo and Clive N May

    Citation: Intensive Care Medicine Experimental 2013 1:4

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  11. Content type: Research

    Adrenomedullin (ADM), a circulating vasodilatory peptide, plays an important role in the development of sepsis-associated hemodynamic and microcirculatory disorders. While administration of exogenous ADM had b...

    Authors: Joachim Struck, Frauke Hein, Siegmund Karasch and Andreas Bergmann

    Citation: Intensive Care Medicine Experimental 2013 1:3

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  12. Content type: Research

    Adrenomedullin (ADM) has been referred to as a double-edged sword during septic shock: On one hand, ADM supplementation improved organ perfusion and function, attenuated systemic inflammation, and ultimately redu...

    Authors: Katja Wagner, Ulrich Wachter, Josef A Vogt, Angelika Scheuerle, Oscar McCook, Sandra Weber, Michael Gröger, Bettina Stahl, Michael Georgieff, Peter Möller, Andreas Bergmann, Frauke Hein, Enrico Calzia, Peter Radermacher and Florian Wagner

    Citation: Intensive Care Medicine Experimental 2013 1:2

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