Articles

Effects of the PPAR-β/δ agonist GW0742 during resuscitated porcine septic shock

In un-resuscitated rodent models of septic shock, the peroxisome proliferator-activated receptor-β/δ (PPAR-β/δ) agonist GW0742 improved visceral organ function. Therefore, we tested the hypothesis whether GW07...

Authors: Martin Wepler, Sebastian Hafner, Angelika Scheuerle, Matthias Reize, Michael Gröger, Florian Wagner, Florian Simon, José Matallo, Frank Gottschalch, Andrea Seifritz, Bettina Stahl, Martin Matejovic, Amar Kapoor, Peter Möller, Enrico Calzia, Michael Georgieff…

IL-1β processing in mechanical ventilation-induced inflammation is dependent on neutrophil factors rather than caspase-1

Mechanical ventilation can cause ventilator-induced lung injury, characterized by a sterile inflammatory response in the lungs resulting in tissue damage and respiratory failure. The cytokine interleukin-1β (I...

Authors: Kim Timmermans, Selina EI van der Wal, Michiel Vaneker, Jeroen AWM van der Laak, Mihai G Netea, Peter Pickkers, Gert Jan Scheffer, Leo AB Joosten and Matthijs Kox

A mouse is not a rat is not a man: species-specific metabolic responses to sepsis - a nail in the coffin of murine models for critical care research?

Authors: Peter Radermacher and Philippe Haouzi

The metabolic phenotype of rodent sepsis: cause for concern?

Rodent models of sepsis are frequently used to investigate pathophysiological mechanisms and to evaluate putative therapeutic strategies. However, preclinical efficacy in these models has failed to translate t...

Authors: Parjam S Zolfaghari, Bernardo Bollen Pinto, Alex Dyson and Mervyn Singer

Activated protein C ameliorates impaired renal microvascular oxygenation and sodium reabsorption in endotoxemic rats

We aimed to test whether continuous recombinant human activated protein C (APC) administration would be able to protect renal oxygenation and function during endotoxemia in order to provide more insight into t...

Authors: Emre Almac, Tanja Johannes, Rick Bezemer, Egbert G Mik, Klaus E Unertl, AB Johan Groeneveld and Can Ince

Acid–base changes after fluid bolus: sodium chloride vs. sodium octanoate

This study aims to test the hypothesis that fluid loading with sodium chloride (150 mmol Na and 150 mmol Cl) or sodium octanoate (150 mmol Na, 100 mmol Cl, and 50 mmol octanoate) would lead to different acid–b...

Authors: Lu Ke, Paolo Calzavacca, Michael Bailey, Wei-qin Li, Rinaldo Bellomo and Clive N May

Epitope specificity of anti-Adrenomedullin antibodies determines efficacy of mortality reduction in a cecal ligation and puncture mouse model

Adrenomedullin (ADM), a circulating vasodilatory peptide, plays an important role in the development of sepsis-associated hemodynamic and microcirculatory disorders. While administration of exogenous ADM had b...

Authors: Joachim Struck, Frauke Hein, Siegmund Karasch and Andreas Bergmann

Adrenomedullin binding improves catecholamine responsiveness and kidney function in resuscitated murine septic shock

Adrenomedullin (ADM) has been referred to as a double-edged sword during septic shock: On one hand, ADM supplementation improved organ perfusion and function, attenuated systemic inflammation, and ultimately redu...

Authors: Katja Wagner, Ulrich Wachter, Josef A Vogt, Angelika Scheuerle, Oscar McCook, Sandra Weber, Michael Gröger, Bettina Stahl, Michael Georgieff, Peter Möller, Andreas Bergmann, Frauke Hein, Enrico Calzia, Peter Radermacher and Florian Wagner