Articles
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Citation: Intensive Care Medicine Experimental 2014 2(Suppl 1):P87
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1069. Pharmacological preconditioning with vitamin c attenuates intestinal injury via the induction of heme oxygenase-1 after hemorrhagic shock in rats
Citation: Intensive Care Medicine Experimental 2014 2(Suppl 1):P85 -
0992. Effects of inhaled aerosolized insulin on acutely injured lungs under normoglycemia: insulin may contribute to enhance alveolar liquid clearance through epithelial sodium channel expression
Citation: Intensive Care Medicine Experimental 2014 2(Suppl 1):P77 -
0730. Plasma endocan levels are associated with endothelial dysfunction during experimental human endotoxemia
Citation: Intensive Care Medicine Experimental 2014 2(Suppl 1):P52 -
0714. Interaction between adipokines and the metabolic stress response: angpt l2 cxcl5 and visfatin in patients undergoing cardiac surgery
Citation: Intensive Care Medicine Experimental 2014 2(Suppl 1):P46 -
0671. Extended extracorporeal lung support in a porcine acute lung injury model. Feasibility and preliminary data
Citation: Intensive Care Medicine Experimental 2014 2(Suppl 1):P44 -
0371. Temporal changes in systemic and renal inflammation and histology in a 72-hour rat model of faecal peritonitis
Citation: Intensive Care Medicine Experimental 2014 2(Suppl 1):P23 -
0353. Do the noble gases helium and argon exert neuroprotective effects in a rodent cardiac arrest model?
Citation: Intensive Care Medicine Experimental 2014 2(Suppl 1):P19 -
0095. Transvenous vagus nerve stimulation does not modulate the innate immune response in humans in vivo during experimental endotoxemia
Citation: Intensive Care Medicine Experimental 2014 2(Suppl 1):P7 -
Brain function in iNOS knock out or iNOS inhibited (l-NIL) mice under endotoxic shock
Microcirculatory dysfunction due to excessive nitric oxide production by the inducible nitric oxide synthase (iNOS) is often seen as a motor of sepsis-related organ dysfunction. Thus, blocking iNOS may improve...
Citation: Intensive Care Medicine Experimental 2014 2:24 -
Can computer simulators accurately represent the pathophysiology of individual COPD patients?
Computer simulation models could play a key role in developing novel therapeutic strategies for patients with chronic obstructive pulmonary disease (COPD) if they can be shown to accurately represent the patho...
Citation: Intensive Care Medicine Experimental 2014 2:23 -
Neutrophil extracellular traps in the host defense against sepsis induced by Burkholderia pseudomallei (melioidosis)
Neutrophil extracellular traps (NETs) are a central player in the host response to bacteria: neutrophils release extracellular DNA (nucleosomes) and neutrophil elastase to entrap and kill bacteria. We studied ...
Citation: Intensive Care Medicine Experimental 2014 2:21 -
Early and dynamic changes in gene expression in septic shock patients: a genome-wide approach
As early and appropriate care of severe septic patients is associated with better outcome, understanding of the very first events in the disease process is needed. Pan-genomic analyses offer an interesting opp...
Citation: Intensive Care Medicine Experimental 2014 2:20 -
The receptor for advanced glycation end products in ventilator-induced lung injury
Mechanical ventilation (MV) can cause ventilator-induced lung injury (VILI). The innate immune response mediates this iatrogenic inflammatory condition. The receptor for advanced glycation end products (RAGE) ...
Citation: Intensive Care Medicine Experimental 2014 2:22 -
A standardized model of brain death, donor treatment, and lung transplantation for studies on organ preservation and reconditioning
We set a model of brain death, donor management, and lung transplantation for studies on lung preservation and reconditioning before transplantation.
Citation: Intensive Care Medicine Experimental 2014 2:12 -
Effects of glycemic control on glucose utilization and mitochondrial respiration during resuscitated murine septic shock
This study aims to test the hypothesis whether lowering glycemia improves mitochondrial function and thereby attenuates apoptotic cell death during resuscitated murine septic shock.
Citation: Intensive Care Medicine Experimental 2014 2:19 -
Regulation of lung oxidative damage by endogenous superoxide dismutase in sepsis
The purpose of this research is to study the relationship between superoxide dismutase (SOD) and lung redox state in an animal model of sepsis.
Citation: Intensive Care Medicine Experimental 2014 2:17 -
Relevance of induced and accidental hypothermia after trauma-haemorrhage–what do we know from experimental models in pigs?
Recent experimental research has either focused on the role of accidental hypothermia as part of the lethal triad after trauma or tried to elucidate the effects of therapeutically induced hypothermia on the po...
Citation: Intensive Care Medicine Experimental 2014 2:16 -
‘Chronomics’ in ICU: circadian aspects of immune response and therapeutic perspectives in the critically ill
Complex interrelations exist between the master central clock, located in the suprachiasmatic nuclei of the hypothalamus, and several peripheral clocks, such as those found in different immune cells of the bod...
Citation: Intensive Care Medicine Experimental 2014 2:18 -
Genetic and pharmacologic inhibition of Tpl2 kinase is protective in a mouse model of ventilator-induced lung injury
Mechanical stress induced by injurious ventilation leads to pro-inflammatory cytokine production and lung injury. The extracellular-signal-regulated-kinase, ERK1/2, participates in the signaling pathways activ...
Citation: Intensive Care Medicine Experimental 2014 2:15 -
Moderately high frequency ventilation with a conventional ventilator allows reduction of tidal volume without increasing mean airway pressure
The aim of this study was to explore if positive-pressure ventilation delivered by a conventional ICU ventilator at a moderately high frequency (HFPPV) allows a safe reduction of tidal volume (VT) below 6 mL/kg i...
Citation: Intensive Care Medicine Experimental 2014 2:13 -
Statins, fibrates, thiazolidinediones and resveratrol as adjunctive therapies in sepsis: could mitochondria be a common target?
Through their pleiotropic actions, statins, fibrates, thiazolidinediones and resveratrol can target multiple mechanisms involved in sepsis. Their actions on mitochondrial function are of interest in a patholog...
Citation: Intensive Care Medicine Experimental 2014 2:9 -
Assessment of ventilation inhomogeneity during mechanical ventilation using a rapid-response oxygen sensor-based oxygen washout method
Ventilatory inhomogeneity indexes in critically ill mechanically ventilated patients could be of importance to optimize ventilator settings in order to reduce additional lung injury. The present study compared...
Citation: Intensive Care Medicine Experimental 2014 2:14 -
Reliability of the nitrogen washin-washout technique to assess end-expiratory lung volume at variable PEEP and tidal volumes
End-expiratory lung volume measurement by the nitrogen washin-washout technique (EELVWI-WO) may help titrating positive end-expiratory pressure (PEEP) during acute respiratory distress syndrome (ARDS). Validation...
Citation: Intensive Care Medicine Experimental 2014 2:10 -
The effect of vitamin C on plasma volume in the early stage of sepsis in the rat
Previous experimental studies have shown that vitamin C has several beneficial effects in sepsis and burns, such as decreased tissue oedema, improved endothelial barrier function and decreased transcapillary l...
Citation: Intensive Care Medicine Experimental 2014 2:11 -
Uncontrolled sepsis: a systematic review of translational immunology studies in intensive care medicine
The design of clinical immunology studies in sepsis presents several fundamental challenges to improving the translational understanding of pathologic mechanisms. We undertook a systematic review of bed-to-ben...
Citation: Intensive Care Medicine Experimental 2014 2:6 -
Bis maltolato oxovanadium (BMOV) and ischemia/reperfusion-induced acute kidney injury in rats
The aim of the present study was to test the potential protective effects of the organic vanadium salt bis (maltolato) oxovanadium (BMOV; 15 mg/kg) in the context of renal ischemia/reperfusion (30 min of ische...
Citation: Intensive Care Medicine Experimental 2014 2:3 -
Administration of intrapulmonary sodium polyacrylate to induce lung injury for the development of a porcine model of early acute respiratory distress syndrome
The loss of alveolar epithelial and endothelial integrity is a central component in acute respiratory distress syndrome (ARDS); however, experimental models investigating the mechanisms of epithelial injury ar...
Citation: Intensive Care Medicine Experimental 2014 2:5 -
Acute organ injury is associated with alterations in the cell-free plasma transcriptome
Despite a genomic revolution in biological sciences, clinical medicine has yet to integrate diagnostics based upon gene expression into practice. While commonly used plasma protein assays rely on organ-specifi...
Citation: Intensive Care Medicine Experimental 2014 2:7 -
Mechanical ventilation with heliox in an animal model of acute respiratory distress syndrome
Heliox has a lower density and higher diffusion capacity compared to oxygen-in-air. We hypothesized that heliox ventilation allows for a reduction in minute volume ventilation and inspiratory pressures needed ...
Citation: Intensive Care Medicine Experimental 2014 2:8 -
A novel echocardiographic imaging technique, intracatheter echocardiography, to guide veno-venous extracorporeal membrane oxygenation cannulae placement in a validated ovine model
Echocardiography plays a fundamental role in cannulae insertion and positioning for extracorporeal membrane oxygenation (ECMO). Optimal access and return cannulae orientation is required to prevent recirculati...
Citation: Intensive Care Medicine Experimental 2014 2:2 -
Unilateral mechanical asymmetry: positional effects on lung volumes and transpulmonary pressure
Ventilated patients with asymmetry of lung or chest wall mechanics may be vulnerable to differing lung stresses or strains dependent on body position. Our purpose was to examine transpulmonary pressure (PTP) and ...
Citation: Intensive Care Medicine Experimental 2014 2:4 -
Adrenomedullin: its double-edged sword during sepsis slices yet again
Citation: Intensive Care Medicine Experimental 2014 2:1 -
Effects of the PPAR-β/δ agonist GW0742 during resuscitated porcine septic shock
In un-resuscitated rodent models of septic shock, the peroxisome proliferator-activated receptor-β/δ (PPAR-β/δ) agonist GW0742 improved visceral organ function. Therefore, we tested the hypothesis whether GW07...
Citation: Intensive Care Medicine Experimental 2013 1:9 -
IL-1β processing in mechanical ventilation-induced inflammation is dependent on neutrophil factors rather than caspase-1
Mechanical ventilation can cause ventilator-induced lung injury, characterized by a sterile inflammatory response in the lungs resulting in tissue damage and respiratory failure. The cytokine interleukin-1β (I...
Citation: Intensive Care Medicine Experimental 2013 1:8 -
A mouse is not a rat is not a man: species-specific metabolic responses to sepsis - a nail in the coffin of murine models for critical care research?
Citation: Intensive Care Medicine Experimental 2013 1:7 -
The metabolic phenotype of rodent sepsis: cause for concern?
Rodent models of sepsis are frequently used to investigate pathophysiological mechanisms and to evaluate putative therapeutic strategies. However, preclinical efficacy in these models has failed to translate t...
Citation: Intensive Care Medicine Experimental 2013 1:6 -
Activated protein C ameliorates impaired renal microvascular oxygenation and sodium reabsorption in endotoxemic rats
We aimed to test whether continuous recombinant human activated protein C (APC) administration would be able to protect renal oxygenation and function during endotoxemia in order to provide more insight into t...
Citation: Intensive Care Medicine Experimental 2013 1:5 -
Acid–base changes after fluid bolus: sodium chloride vs. sodium octanoate
This study aims to test the hypothesis that fluid loading with sodium chloride (150 mmol Na and 150 mmol Cl) or sodium octanoate (150 mmol Na, 100 mmol Cl, and 50 mmol octanoate) would lead to different acid–b...
Citation: Intensive Care Medicine Experimental 2013 1:4 -
Epitope specificity of anti-Adrenomedullin antibodies determines efficacy of mortality reduction in a cecal ligation and puncture mouse model
Adrenomedullin (ADM), a circulating vasodilatory peptide, plays an important role in the development of sepsis-associated hemodynamic and microcirculatory disorders. While administration of exogenous ADM had b...
Citation: Intensive Care Medicine Experimental 2013 1:3 -
Adrenomedullin binding improves catecholamine responsiveness and kidney function in resuscitated murine septic shock
Adrenomedullin (ADM) has been referred to as a double-edged sword during septic shock: On one hand, ADM supplementation improved organ perfusion and function, attenuated systemic inflammation, and ultimately redu...
Citation: Intensive Care Medicine Experimental 2013 1:2 -
A new dawn for critical care research
Citation: Intensive Care Medicine Experimental 2013 1:1
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- ISSN: 2197-425X (electronic)