Articles
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Citation: Intensive Care Medicine Experimental 2015 3(Suppl 1):A1009
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Inferior vena cava filters in the intensive care unit population: single center experience in the united arab emirates
Citation: Intensive Care Medicine Experimental 2015 3(Suppl 1):A970 -
Sats can be used for mortality prediction
Citation: Intensive Care Medicine Experimental 2015 3(Suppl 1):A966 -
A new bedside prediction rule to assess liver allografts viability in icu admitted donors
Citation: Intensive Care Medicine Experimental 2015 3(Suppl 1):A895 -
Validation of the probability of survival using the triss methodology in the Spanish Trauma ICU registry (RETRAUCI)
Citation: Intensive Care Medicine Experimental 2015 3(Suppl 1):A856 -
Epidemiology of sepsis in brazilian icus: a nationwide stratified sample
Citation: Intensive Care Medicine Experimental 2015 3(Suppl 1):A642 -
Diagnostic performance of ct angiography for gastrointestinal haemorrhage according to the clinical severity
Citation: Intensive Care Medicine Experimental 2015 3(Suppl 1):A605 -
Pressure-support improves lung protection and reduces cardiovascular dysfunction compared to pressure-controlled ventilation in experimental emphysema
Citation: Intensive Care Medicine Experimental 2015 3(Suppl 1):A569 -
Levosimendan use in critical care - a case series
Citation: Intensive Care Medicine Experimental 2015 3(Suppl 1):A540 -
The effect of increased unplanned surgical admissions at a 12 bed critical care unit
Citation: Intensive Care Medicine Experimental 2015 3(Suppl 1):A534 -
The Diagnostic Utility of Early Ct Brain Imaging in Poisoned Intensive Care Patients
Citation: Intensive Care Medicine Experimental 2015 3(Suppl 1):A498 -
Elevation of serum phosphorus, an early biomarker of acute kidney injury after cardiac sugery?
Citation: Intensive Care Medicine Experimental 2015 3(Suppl 1):A465 -
Guidewire exchange vs new-site placement for temporary dialysis catheters insertion in ICU patients: is there a greater risk of colonization or dysfunction?
Citation: Intensive Care Medicine Experimental 2015 3(Suppl 1):A463 -
IMPACT OF TRIALS ON CLINICAL PRACTICE: INTERVENTIONS IN SEPTIC SHOCK PATIENTS BETWEEN 2005 AND 2013
Citation: Intensive Care Medicine Experimental 2015 3(Suppl 1):A430 -
Therapeutic drug monitoring of meropenem and piperacilin administered in continuous infusion. preliminary data
Citation: Intensive Care Medicine Experimental 2015 3(Suppl 1):A394 -
Personalised glucose therapy: glucose targets in critically ill patients with pre-existing poorly controlled type 2 diabetes
Citation: Intensive Care Medicine Experimental 2015 3(Suppl 1):A290 -
Impact of oncologic pathology (OP) in the evolution of severe sepsis (SS) in the critically ill patients (CIP)
Citation: Intensive Care Medicine Experimental 2015 3(Suppl 1):A247 -
Functional status in ICU survivors and out of hospital outcomes
Citation: Intensive Care Medicine Experimental 2015 3(Suppl 1):A178 -
High flow nasal cannula improves lung aeration and enhances CO2 removal in hypoxemic critically ill patients
Citation: Intensive Care Medicine Experimental 2015 3(Suppl 1):A176 -
Evaluation of Antibiotic Treatment And Antibiotic De-Escalation in a Intensive Care Unit With Selective Digestive Decontamination
Citation: Intensive Care Medicine Experimental 2015 3(Suppl 1):A2 -
The role of dexamethasone in scorpion venom-induced deregulation of sodium and water transport in rat lungs
Severe scorpion envenomation can evolve to lung injury and, in some cases, death. The lung injury could be attributed to acute left ventricular failure and increased pulmonary vascular permeability secondary t...
Citation: Intensive Care Medicine Experimental 2015 3:28 -
Accelerated clearance of human red blood cells in a rat transfusion model
Animal models are valuable in transfusion research. Use of human red blood cells (RBCs) in animal models facilitates extrapolation of the impact of storage conditions to the human condition but may be hampered...
Citation: Intensive Care Medicine Experimental 2015 3:27 -
Tumor necrosis factor receptor 1 (TNFRI) for ventilator-associated pneumonia diagnosis by cytokine multiplex analysis
The diagnosis of ventilator-associated pneumonia (VAP) is challenging. An important aspect to improve outcome is early recognition of VAP and the initiation of the appropriate empirical treatment. We hypothesi...
Citation: Intensive Care Medicine Experimental 2015 3:26 -
Successful ECMO-cardiopulmonary resuscitation with the associated post-arrest cardiac dysfunction as demonstrated by MRI
Veno-arterial extracorporeal membrane oxygenation (ECMO-CPR) is a life-saving rescue for selected patients when standard cardiopulmonary resuscitation fails. The use is increasing although the treatment modali...
Citation: Intensive Care Medicine Experimental 2015 3:25 -
Catheter securement systems: comparison of two investigational devices to a sutureless securement device, a securement dressing, and sutures in a pig model
Catheter securement is critical for the success of infusion therapy and to prevent complications. Our purpose was to compare the strength of catheter securement achieved with two investigational adhesive secur...
Citation: Intensive Care Medicine Experimental 2015 3:24 -
Impairment of neutrophilic glucocorticoid receptor function in patients treated with steroids for septic shock
Glucocorticoid (GC) treatment has variable effect in sepsis. This may be explained by decreased expression or function of the glucocorticoid receptor (GR). The aim of this study was to determine GR expression ...
Citation: Intensive Care Medicine Experimental 2015 3:23 -
Analysis of the influence of antithrombin on microvascular thrombosis: anti-inflammation is crucial for anticoagulation
Microvascular thrombosis during septic conditions is of essential clinical relevance, but the pathomechanisms are not yet completely understood. The purpose of this study was to study the distinguished differe...
Citation: Intensive Care Medicine Experimental 2015 3:22 -
Scavenging reactive oxygen species using tempol in the acute phase of renal ischemia/reperfusion and its effects on kidney oxygenation and nitric oxide levels
Renal ischemia/reperfusion (I/R) injury is commonly seen in kidney transplantation and affects the allograft survival rates. We aimed to test our hypothesis that scavenging reactive oxygen species (ROS) with t...
Citation: Intensive Care Medicine Experimental 2015 3:21 -
A randomized clinical trial of ascorbic acid in open abdominal aortic aneurysm repair
Open AAA repair is associated with ischaemia-reperfusion injury where systemic inflammation and endothelial dysfunction can lead to multiple organ injury including acute lung injury. Oxidative stress plays a r...
Citation: Intensive Care Medicine Experimental 2015 3:20 -
Critical illness-induced bone loss is related to deficient autophagy and histone hypomethylation
Survivors of critical illness are at increased risk of fractures. This may be due to increased osteoclast formation during critical illness, leading to trabecular bone loss. Such bone loss has also been observ...
Citation: Intensive Care Medicine Experimental 2015 3:19 -
Atelectasis causes alveolar hypoxia-induced inflammation during uneven mechanical ventilation in rats
Patients with acute respiratory distress syndrome receiving mechanical ventilation show inhomogeneous lung aeration. Atelectasis during uneven mechanical ventilation leads to alveolar hypoxia and could therefo...
Citation: Intensive Care Medicine Experimental 2015 3:18 -
Prone position ameliorates lung elastance and increases functional residual capacity independently from lung recruitment
Prone position is used to recruit collapsed dependent lung regions during severe acute respiratory distress syndrome, improving lung elastance and lung gas content. We hypothesised that, in the absence of recr...
Citation: Intensive Care Medicine Experimental 2015 3:17 -
Alveolar instability (atelectrauma) is not identified by arterial oxygenation predisposing the development of an occult ventilator-induced lung injury
Improperly set mechanical ventilation (MV) with normal lungs can advance lung injury and increase the incidence of acute respiratory distress syndrome (ARDS). A key mechanism of ventilator-induced lung injury ...
Citation: Intensive Care Medicine Experimental 2015 3:16 -
Interactions between rat alveolar epithelial cells and bone marrow-derived mesenchymal stem cells: an in vitro co-culture model
Bone marrow-derived mesenchymal stem cells (BMSCs) reduced the severity of acute lung injury after transplantation in multiple experimental studies, and several paracrine soluble factors secreted by the cells ...
Citation: Intensive Care Medicine Experimental 2015 3:15 -
Effects of early hemodynamic resuscitation on left ventricular performance and microcirculatory function during endotoxic shock
Microcirculation and macrohemodynamics are severely compromised during septic shock. However, the relationship between these two compartments needs to be further investigated. We hypothesized that early resusc...
Citation: Intensive Care Medicine Experimental 2015 3:14 -
An authentic animal model of the very preterm infant on nasal continuous positive airway pressure
The surge in uptake of nasal continuous positive airway pressure (CPAP) for respiratory support in preterm infants has occurred in the absence of an authentic animal model. Such a model would allow investigati...
Citation: Intensive Care Medicine Experimental 2015 3:13 -
Why do they die? Comparison of selected aspects of organ injury and dysfunction in mice surviving and dying in acute abdominal sepsis
The mechanisms of sepsis mortality remain undefined. While there is some evidence of organ damage, it is not clear whether this damage alone is sufficient to cause death. Therefore, we aimed to examine contrib...
Citation: Intensive Care Medicine Experimental 2015 3:12 -
Effects of norepinephrine on tissue perfusion in a sheep model of intra-abdominal hypertension
The aim of the study was to describe the effects of intra-abdominal hypertension (IAH) on regional and microcirculatory intestinal blood flow, renal blood flow, and urine output, as well as their response to i...
Citation: Intensive Care Medicine Experimental 2015 3:11 -
An improved mounting device for attaching intracranial probes in large animal models
The rigid support of intracranial probes can be difficult when using animal models, as mounting devices suitable for the probes are either not available, or designed for human use and not suitable in animal sk...
Citation: Intensive Care Medicine Experimental 2015 3:10 -
Raxibacumab augments hemodynamic support and improves outcomes during shock with B. anthracis edema toxin alone or together with lethal toxin in canines
Lethal and edema toxin contribute to shock and lethality with Bacillus anthracis. We showed previously in a 96-h sedated canine model that raxibacumab, a monoclonal antibody against protective antigen, augmented ...
Citation: Intensive Care Medicine Experimental 2015 3:9 -
Angiotensin-(1-7) improves oxygenation, while reducing cellular infiltrate and fibrosis in experimental Acute Respiratory Distress Syndrome
The renin-angiotensin system (RAS) plays a role in the pathogenesis of ARDS, Angiotensin II (Ang-II) contributing to the pathogenesis of inflammation and fibrogenesis. Angiotensin-(1-7) (Ang-(1-7)) may antagon...
Citation: Intensive Care Medicine Experimental 2015 3:8 -
Shape descriptors of the “never resting” microglia in three different acute brain injury models in mice
The study of microglia and macrophage (M/M) morphology represents a key tool to understand the functional activation state and the pattern of distribution of these cells in acute brain injury. The identificati...
Citation: Intensive Care Medicine Experimental 2015 3:7 -
Systolic left ventricular function is preserved during therapeutic hypothermia, also during increases in heart rate with impaired diastolic filling
Systolic left ventricular function during therapeutic hypothermia is found both to improve and to decline. We hypothesized that this discrepancy would depend on the heart rate and the variables used to assess ...
Citation: Intensive Care Medicine Experimental 2015 3:6 -
Attenuated platelet aggregation in patients with septic shock is independent from the activity state of myosin light chain phosphorylation or a reduction in Rho kinase-dependent inhibition of myosin light chain phosphatase
Impaired coagulation contributes to the morbidity and mortality associated with septic shock. Whether abnormal platelet contraction adds to the bleeding tendency is unknown. Platelets contract when Ca2+-dependent...
Citation: Intensive Care Medicine Experimental 2015 3:5 -
Cytocam-IDF (incident dark field illumination) imaging for bedside monitoring of the microcirculation
Orthogonal polarized spectral (OPS) and sidestream dark field (SDF) imaging video microscope devices were introduced for observation of the microcirculation but, due to technical limitations, have remained as ...
Citation: Intensive Care Medicine Experimental 2015 3:4 -
Effect of body position on ventilation distribution during PEEP titration in a porcine model of acute lung injury using advanced respiratory monitoring and electrical impedance tomography
Lung failure after acute lung injury remains a challenge in different clinical settings. Various interventions for restoration of gas exchange have been investigated. Recruitment of collapsed alveoli by positi...
Citation: Intensive Care Medicine Experimental 2015 3:3 -
Calcium desensitisation in late polymicrobial sepsis is associated with loss of vasopressor sensitivity in a murine model
Sepsis is characterised by diminished vasopressor responsiveness. Vasoconstriction depends upon a balance: Ca2+-dependent myosin light-chain kinase promotes and Ca2+-independent myosin light-chain phosphatase (ML...
Citation: Intensive Care Medicine Experimental 2015 3:2 -
Sepsis protects the myocardium and other organs from subsequent ischaemic/reperfusion injury via a MAPK-dependent mechanism
Sepsis has been shown to precondition the intact heart against ischaemia/reperfusion (IR) injury, and prior endotoxin exposure of cells in in vitro models has shown evidence of protection against subsequent simul...
Citation: Intensive Care Medicine Experimental 2015 3:1 -
Systemic and renal hemodynamic effects of intra-arterial radiocontrast
Decreased renal blood flow (RBF) and vasoconstriction are considered major mechanisms of contrast-induced acute kidney injury (CIAKI). To understand the severity and duration of such putative effects, we measu...
Citation: Intensive Care Medicine Experimental 2014 2:32 -
Sepsis-induced acute kidney injury by standardized colon ascendens stent peritonitis in rats - a simple, reproducible animal model
Up to 50% of septic patients develop acute kidney injury (AKI). The pathomechanism of septic AKI is poorly understood. Therefore, we established an innovative rodent model to characterize sepsis-induced AKI by...
Citation: Intensive Care Medicine Experimental 2014 2:34
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- ISSN: 2197-425X (electronic)