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  1. Content type: Research

    Multiple organ failure, wasting, increased morbidity, and mortality following acute illness complicates the health span of patients surviving sepsis. Persistent inflammation has been implicated, and it is prop...

    Authors: Ata Murat Kaynar, Veli Bakalov, Silvia Martinez Laverde, Amélie I. F. Cambriel, Byoung-Hoon Lee, Atif Towheed, Alyssa D. Gregory, Steven A. R. Webb, Michael J. Palladino, Fernando A. Bozza, Steven D. Shapiro and Derek C. Angus

    Citation: Intensive Care Medicine Experimental 2016 4:4

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  2. Content type: Research

    Cerebral cytoplasmatic redox state is a sensitive indicator of cerebral oxidative metabolism and is conventionally evaluated from the extracellular lactate/pyruvate (LP) ratio. In the present experimental stud...

    Authors: Rasmus Jakobsen, Troels Halfeld Nielsen, Asger Granfeldt, Palle Toft and Carl-Henrik Nordström

    Citation: Intensive Care Medicine Experimental 2016 4:3

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  3. Content type: Research

    Extracorporeal carbon dioxide removal (ECCO2R) has been gaining interest to potentially facilitate gas transfer and equilibrate mild to moderate hypercapnic acidosis, when standard therapy with non-invasive venti...

    Authors: A. S. Sharma, P. W. Weerwind, O. Bekers, E. M. Wouters and J. G. Maessen

    Citation: Intensive Care Medicine Experimental 2016 4:2

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  4. Content type: Research

    Extracorporeal membrane oxygenation (ECMO) is a technique widely used worldwide to improve gas exchange. Changes in ECMO settings affect both oxygen and carbon dioxide. The impact on oxygenation can be followe...

    Authors: Pedro Vitale Mendes, Marcelo Park, Alexandre Toledo Maciel, Débora Prudêncio e Silva, Natalia Friedrich, Edzangela Vasconcelos Santos Barbosa, Adriana Sayuri Hirota, Guilherme Pinto Paula Schettino, Luciano Cesar Pontes Azevedo and Eduardo Leite Vieira Costa

    Citation: Intensive Care Medicine Experimental 2016 4:1

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  5. Content type: Research

    Intra-arrest hypothermia induction may provide more benefit than inducing hypothermia after return of spontaneous circulation. However, little is understood about the interaction between patient physiology and...

    Authors: Joshua W. Lampe, George Bratinov, Theodore R. Weiland III, Uday Illindala, Robert A. Berg and Lance B. Becker

    Citation: Intensive Care Medicine Experimental 2015 3:37

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  6. Content type: Research

    The beneficial effects of heparin in the treatment of severe sepsis, septic shock, and sepsis-associated disseminated intravascular coagulation (DIC) have recently been reported. However, the mechanisms underl...

    Authors: Toshiaki Iba, Naoyuki Hashiguchi, Isao Nagaoka, Yoko Tabe, Katsuhiko Kadota and Koichi Sato

    Citation: Intensive Care Medicine Experimental 2015 3:36

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  7. Content type: Research

    Lung injury is often studied without consideration for pathologic changes in the chest wall. In order to reduce the incidence of lung injury using preemptive mechanical ventilation, it is important to recogniz...

    Authors: Michaela Kollisch-Singule, Bryanna Emr, Sumeet V. Jain, Penny Andrews, Joshua Satalin, Jiao Liu, Elizabeth Porcellio, Van Kenyon, Guirong Wang, William Marx, Louis A. Gatto, Gary F. Nieman and Nader M. Habashi

    Citation: Intensive Care Medicine Experimental 2015 3:35

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  8. Content type: Research

    High tidal volume can cause ventilator-induced lung injury (VILI), but positive end-expiratory pressure (PEEP) is thought to be protective. We aimed to find the volumetric VILI threshold and see whether PEEP i...

    Authors: Alessandro Protti, Davide T. Andreis, Marta Milesi, Giacomo E. Iapichino, Massimo Monti, Beatrice Comini, Paola Pugni, Valentina Melis, Alessandro Santini, Daniele Dondossola, Stefano Gatti, Luciano Lombardi, Emiliano Votta, Eleonora Carlesso and Luciano Gattinoni

    Citation: Intensive Care Medicine Experimental 2015 3:34

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  9. Content type: Research

    A recent prospective trial using porcine models of severe acute respiratory distress syndrome (ARDS) indicated that positive-pressure ventilation delivered by a conventional intensive care ventilator at a mode...

    Authors: Wenfei Wang, Anup Das, Oanna Cole, Marc Chikhani, Jonathan G. Hardman and Declan G. Bates

    Citation: Intensive Care Medicine Experimental 2015 3:33

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  10. Content type: Research

    Blast lung injuries (BLI) caused by blast waves are extremely critical in the prehospital setting, and hypotension is thought to be the main cause of death in such cases. The present study aimed to elucidate t...

    Authors: Hiroki Miyawaki, Daizoh Saitoh, Kohsuke Hagisawa, Midori Noguchi, Shunichi Sato, Manabu Kinoshita, Hiromi Miyazaki, Yasushi Satoh, Nahoko Harada and Toshihisa Sakamoto

    Citation: Intensive Care Medicine Experimental 2015 3:32

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  11. Content type: Research

    Upregulation of the endothelin axis has been observed in pulmonary tissue after brain death, contributing to primary graft dysfunction and ischaemia reperfusion injury. The current study aimed to develop a nov...

    Authors: Ryan P. Watts, Izabela Bilska, Sara Diab, Kimble R. Dunster, Andrew C. Bulmer, Adrian G. Barnett and John F. Fraser

    Citation: Intensive Care Medicine Experimental 2015 3:31

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  12. Content type: Review

    Several mechanisms are associated with brain dysfunction during sepsis; one of the most important are activation of microglia and astrocytes. Activation of glial cells induces changes in permeability of the bl...

    Authors: Monique Michels, Amanda V. Steckert, João Quevedo, Tatiana Barichello and Felipe Dal-Pizzol

    Citation: Intensive Care Medicine Experimental 2015 3:30

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  13. Content type: Research

    The potential for mesenchymal stem cells (MSCs) to reduce the severity of experimental lung injury has been established in several pre-clinical studies. We have recently demonstrated that MSCs, and MSC-secrete...

    Authors: Mairead Hayes, Gerard F. Curley, Claire Masterson, James Devaney, Daniel O’Toole and John G. Laffey

    Citation: Intensive Care Medicine Experimental 2015 3:29

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  14. Content type: Poster presentation

    Citation: Intensive Care Medicine Experimental 2015 3(Suppl 1):A858

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    This article is part of a Supplement: Volume 3 Supplement 1