Articles

Transcriptional reprogramming of metabolic pathways in critically ill patients

Critical illness causes a shift away from mitochondrial metabolism towards a greater dependence on glycolysis. This metabolic shift is thought to be associated with lactic acidosis, organ dysfunction and poor ...

Authors: Marek Nalos, Grant Parnell, Robert Robergs, David Booth, Anthony S. McLean and Benjamin M. Tang

Modulatory effects of vagal stimulation on neurophysiological parameters and the cellular immune response in the rat brain during systemic inflammation

Stimulation of the vagus nerve has modulating, anti-inflammatory effects on the cellular immune response in the blood and the spleen, stabilizing brain function. Here, we aimed to investigate its potential eff...

Authors: Hanna Schweighöfer, Christoph Rummel, Joachim Roth and Bernhard Rosengarten

Erratum to: Left ventricular function during porcine-resuscitated septic shock with pre-existing atherosclerosis

Authors: Benedikt L. Nußbaum, Oscar McCook, Clair Hartmann, José Matallo, Martin Wepler, Elena Antonucci, Miriam Kalbitz, Markus Huber-Lang, Michael Georgieff, Enrico Calzia, Peter Radermacher and Sebastian Hafner

Microcirculatory perfusion shows wide inter-individual variation and is important in determining shock reversal during resuscitation in a porcine experimental model of complex traumatic hemorrhagic shock

Traumatic hemorrhagic shock (THS) is a leading cause of preventable death following severe traumatic injury. Resuscitation of THS is typically targeted at blood pressure, but the effects of such a strategy on ...

Authors: Sam D. Hutchings, David N. Naumann, Sarah Watts, Callie Wilson, Clare Burton, Julia Wendon and Emrys Kirkman

Lung stress, strain, and energy load: engineering concepts to understand the mechanism of ventilator-induced lung injury (VILI)

It was recently shown that acute respiratory distress syndrome (ARDS) mortality has not been reduced in over 15 years and remains ~40 %, even with protective low tidal volume (LVt) ventilation. Thus, there is ...

Authors: Gary F. Nieman, Joshua Satalin, Penny Andrews, Nader M. Habashi and Louis A. Gatto

Erratum to: Comparison of the evolution of mechanical ventilation associated pneumonia (VAP) before the implantation of selective digestive decontamination (DDS) and after implantation of pneumonia zero program (NZ)

Authors: R. Fernández Fernández, M. Herreros Gonzalo, L. Serrano Fernández, L. Camacho Peinado, N. Cruza Leganés, M. Á. Taberna Izquierdo, F. Alba García and F. Árbol Linde

Left ventricular function during porcine-resuscitated septic shock with pre-existing atherosclerosis

Reversible, depressed cardiac function is frequently encountered during septic shock and commonly called septic cardiomyopathy. Previous studies demonstrated reduced ejection fraction and left ventricular dila...

Authors: Benedikt L. Nußbaum, Oscar McCook, Clair Hartmann, José Matallo, Martin Wepler, Elena Antonucci, Miriam Kalbitz, Markus Huber-Lang, Michael Georgieff, Enrico Calzia, Peter Radermacher and Sebastian Hafner

Comparison between pressure-recording analytical method (PRAM) and femoral arterial thermodilution method (FATD) cardiac output monitoring in an infant animal model of cardiac arrest

The pressure-recording analytical method is a new semi-invasive method for cardiac output measurement (PRAM). There are no studies comparing this technique with femoral artery thermodilution (FATD) in an infan...

Authors: Javier Urbano, Jorge López, Rafael González, Sarah N. Fernández, María José Solana, Blanca Toledo, Ángel Carrillo and Jesús López-Herce

Cross-species validation of cell cycle arrest markers for acute kidney injury in the rat during sepsis

The recent discovery of cell cycle arrest biomarkers, tissue inhibitor of metalloproteinases (TIMP)-2 and insulin-like growth factor binding protein 7 (IGFBP7), has led to a newly available clinical test for a...

Authors: Zhi-Yong Peng, Feihu Zhou and John A. Kellum

The 30-year evolution of airway pressure release ventilation (APRV)

Airway pressure release ventilation (APRV) was first described in 1987 and defined as continuous positive airway pressure (CPAP) with a brief release while allowing the patient to spontaneously breathe through...

Authors: Sumeet V. Jain, Michaela Kollisch-Singule, Benjamin Sadowitz, Luke Dombert, Josh Satalin, Penny Andrews, Louis A. Gatto, Gary F. Nieman and Nader M. Habashi

Critical illness polyneuropathy in ICU patients is related to reduced motor nerve excitability caused by reduced sodium permeability

Reduced motor and sensory nerve amplitudes in critical illness polyneuropathy (CIP) are characteristic features described in electrophysiological studies and due to dysfunction of voltage-gated sodium channels...

Authors: Susanne Koch, Jeffrey Bierbrauer, Kurt Haas, Simone Wolter, Julian Grosskreutz, Friedrich C. Luft, Claudia D. Spies, Jens Fielitz and Steffen Weber-Carstens

Serum proteomics as a strategy to identify novel biomarkers of neurologic recovery after cardiac arrest: a feasibility study

Serum biomarkers may play a role in prognostication after cardiac arrest. This study was designed to assess the feasibility of using two-dimensional gel electrophoresis (2D-GE) coupled with mass spectrometry (...

Authors: J. Gordon Boyd, Laura J. Smithson, Daniel Howes, John Muscedere and Michael D. Kawaja

Hypercapnic acidosis attenuates pulmonary epithelial stretch-induced injury via inhibition of the canonical NF-κB pathway

Hypercapnia, with its associated acidosis (HCA), is a consequence of respiratory failure and is also seen in critically ill patients managed with conventional “protective” ventilation strategies. Nuclear facto...

Authors: Shahd Horie, Bilal Ansari, Claire Masterson, James Devaney, Michael Scully, Daniel O’Toole and John G. Laffey

Quantification of perflutren microsphere contrast destruction during transit through an ex vivo extracorporeal membrane oxygenation circuit

Echocardiography is a key investigation in the management of patients on extracorporeal membrane oxygenation (ECMO). However, echocardiographic images are often non-diagnostic in this patient population. Contr...

Authors: David G. Platts, Charles McDonald, Kiran Shekar, Darryl J. Burstow, Daniel Mullany, Marc Ziegenfuss, Sara Diab and John F. Fraser

Effects of fresh frozen plasma, Ringer’s acetate and albumin on plasma volume and on circulating glycocalyx components following haemorrhagic shock in rats

Early use of fresh frozen plasma (FFP) in haemorrhagic shock is associated with improved outcome. This effect may partly be due to protection of the endothelial glycocalyx and/or secondary to a superior effica...

Authors: Axel Nelson, Svajunas Statkevicius, Ulf Schött, Pär I. Johansson and Peter Bentzer

Modulation of monocytes in septic patients: preserved phagocytic activity, increased ROS and NO generation, and decreased production of inflammatory cytokines

The nature of the inflammatory response underscoring the pathophysiology of sepsis has been extensively studied. We hypothesized that different cell functions would be differentially regulated in a patient wit...

Authors: Sidnéia S. Santos, Amanda M. Carmo, Milena K. C. Brunialti, Flavia R. Machado, Luciano C. Azevedo, Murillo Assunção, Sílvia C. Trevelin, Fernando Q. Cunha and Reinaldo Salomao

Cost of surviving sepsis: a novel model of recovery from sepsis in Drosophila melanogaster

Multiple organ failure, wasting, increased morbidity, and mortality following acute illness complicates the health span of patients surviving sepsis. Persistent inflammation has been implicated, and it is prop...

Authors: Ata Murat Kaynar, Veli Bakalov, Silvia Martinez Laverde, Amélie I. F. Cambriel, Byoung-Hoon Lee, Atif Towheed, Alyssa D. Gregory, Steven A. R. Webb, Michael J. Palladino, Fernando A. Bozza, Steven D. Shapiro and Derek C. Angus

A technique for continuous bedside monitoring of global cerebral energy state

Cerebral cytoplasmatic redox state is a sensitive indicator of cerebral oxidative metabolism and is conventionally evaluated from the extracellular lactate/pyruvate (LP) ratio. In the present experimental stud...

Authors: Rasmus Jakobsen, Troels Halfeld Nielsen, Asger Granfeldt, Palle Toft and Carl-Henrik Nordström

Carbon dioxide dialysis in a swine model utilizing systemic and regional anticoagulation

Extracorporeal carbon dioxide removal (ECCO₂R) has been gaining interest to potentially facilitate gas transfer and equilibrate mild to moderate hypercapnic acidosis, when standard therapy with non-invasive venti...

Authors: A. S. Sharma, P. W. Weerwind, O. Bekers, E. M. Wouters and J. G. Maessen

Kinetics of arterial carbon dioxide during veno-venous extracorporeal membrane oxygenation support in an apnoeic porcine model

Extracorporeal membrane oxygenation (ECMO) is a technique widely used worldwide to improve gas exchange. Changes in ECMO settings affect both oxygen and carbon dioxide. The impact on oxygenation can be followe...

Authors: Pedro Vitale Mendes, Marcelo Park, Alexandre Toledo Maciel, Débora Prudêncio e Silva, Natalia Friedrich, Edzangela Vasconcelos Santos Barbosa, Adriana Sayuri Hirota, Guilherme Pinto Paula Schettino, Luciano Cesar Pontes Azevedo and Eduardo Leite Vieira Costa

Volume infusion cooling increases end-tidal carbon dioxide and results in faster and deeper cooling during intra-cardiopulmonary resuscitation hypothermia induction

Intra-arrest hypothermia induction may provide more benefit than inducing hypothermia after return of spontaneous circulation. However, little is understood about the interaction between patient physiology and...

Authors: Joshua W. Lampe, George Bratinov, Theodore R. Weiland III, Uday Illindala, Robert A. Berg and Lance B. Becker

Heparins attenuated histone-mediated cytotoxicity in vitro and improved the survival in a rat model of histone-induced organ dysfunction

The beneficial effects of heparin in the treatment of severe sepsis, septic shock, and sepsis-associated disseminated intravascular coagulation (DIC) have recently been reported. However, the mechanisms underl...

Authors: Toshiaki Iba, Naoyuki Hashiguchi, Isao Nagaoka, Yoko Tabe, Katsuhiko Kadota and Koichi Sato

The effects of airway pressure release ventilation on respiratory mechanics in extrapulmonary lung injury

Lung injury is often studied without consideration for pathologic changes in the chest wall. In order to reduce the incidence of lung injury using preemptive mechanical ventilation, it is important to recogniz...

Authors: Michaela Kollisch-Singule, Bryanna Emr, Sumeet V. Jain, Penny Andrews, Joshua Satalin, Jiao Liu, Elizabeth Porcellio, Van Kenyon, Guirong Wang, William Marx, Louis A. Gatto, Gary F. Nieman and Nader M. Habashi

Lung anatomy, energy load, and ventilator-induced lung injury

High tidal volume can cause ventilator-induced lung injury (VILI), but positive end-expiratory pressure (PEEP) is thought to be protective. We aimed to find the volumetric VILI threshold and see whether PEEP i...

Authors: Alessandro Protti, Davide T. Andreis, Marta Milesi, Giacomo E. Iapichino, Massimo Monti, Beatrice Comini, Paola Pugni, Valentina Melis, Alessandro Santini, Daniele Dondossola, Stefano Gatti, Luciano Lombardi, Emiliano Votta, Eleonora Carlesso and Luciano Gattinoni

Computational simulation indicates that moderately high-frequency ventilation can allow safe reduction of tidal volumes and airway pressures in ARDS patients

A recent prospective trial using porcine models of severe acute respiratory distress syndrome (ARDS) indicated that positive-pressure ventilation delivered by a conventional intensive care ventilator at a mode...

Authors: Wenfei Wang, Anup Das, Oanna Cole, Marc Chikhani, Jonathan G. Hardman and Declan G. Bates

Noradrenalin effectively rescues mice from blast lung injury caused by laser-induced shock waves

Blast lung injuries (BLI) caused by blast waves are extremely critical in the prehospital setting, and hypotension is thought to be the main cause of death in such cases. The present study aimed to elucidate t...

Authors: Hiroki Miyawaki, Daizoh Saitoh, Kohsuke Hagisawa, Midori Noguchi, Shunichi Sato, Manabu Kinoshita, Hiromi Miyazaki, Yasushi Satoh, Nahoko Harada and Toshihisa Sakamoto

Novel 24-h ovine model of brain death to study the profile of the endothelin axis during cardiopulmonary injury

Upregulation of the endothelin axis has been observed in pulmonary tissue after brain death, contributing to primary graft dysfunction and ischaemia reperfusion injury. The current study aimed to develop a nov...

Authors: Ryan P. Watts, Izabela Bilska, Sara Diab, Kimble R. Dunster, Andrew C. Bulmer, Adrian G. Barnett and John F. Fraser

Mechanisms of long-term cognitive dysfunction of sepsis: from blood-borne leukocytes to glial cells

Several mechanisms are associated with brain dysfunction during sepsis; one of the most important are activation of microglia and astrocytes. Activation of glial cells induces changes in permeability of the bl...

Authors: Monique Michels, Amanda V. Steckert, João Quevedo, Tatiana Barichello and Felipe Dal-Pizzol

Mesenchymal stromal cells are more effective than the MSC secretome in diminishing injury and enhancing recovery following ventilator-induced lung injury

The potential for mesenchymal stem cells (MSCs) to reduce the severity of experimental lung injury has been established in several pre-clinical studies. We have recently demonstrated that MSCs, and MSC-secrete...

Authors: Mairead Hayes, Gerard F. Curley, Claire Masterson, James Devaney, Daniel O’Toole and John G. Laffey

Outcomes of critical patients with tracheostomy: proposal of a decannulation protocol

Authors: C Duro, C Granja, S Castro, A Cardoso and S Mestre

Impact of proactive nurse participation in ICU family conferences: a mixed-method study

Authors: M Garrouste-Orgeas, A Max, C Grégoire, S Ruckly, M Kloeckner, S Brochon, E Pichot, C Simons, M El Mhadri, C Bruel, F Philippart, J Fournier, K Tiercelet, J-F Timsit and B Misset

Brain death and potential organ donors in neurocritical care mortality

Authors: V Spatenkova, O Bradac and P Suchomel

Introduction of weekly multidisciplinary teammeetings in a tertiary cardiothoracic critical care unit: evaluation of staff satisfaction and impact on clinical outcomes

Authors: S Gelvez-Zapata, R D'Oliveiro, K Eriksson, J Bracken, M Pontin and N Jones

A quality improvement comparative audit on theimpact of competency based basic intensive care medicine (ICM) training on the confidence levels of medical senior house officers registrars dealing with intensive care procedures in acutely ill patients

Authors: V Gulia, A Goel, S Kumari, R Kumari and N Arora

Characteristics associated with low risk of significant coronary stenosis after an episode of acute coronary syndrome

Authors: R Blancas, Ó Martínez González, M Chana, D Ballesteros, B López Matamal, MÁ Alonso and C Martín Parra

Lung protective vs. standard ventilation during laparoscopic surgery in obese patients. preliminary results of a randomized, controlled trial

Authors: DL Grieco, A Russo, MS Vallecoccia, L Polidori, B Costantini, V Simili, F Varone, G Scambia, E Marana and M Antonelli

ECCO₂R, a french national survey

Authors: B Deniau, JD Ricard, J Messika, D Dreyfuss and S Gaudry

Radiation overdose: the utility of ct scanning in self poisoning

Authors: G Sondh, S Noble, RI Docking, P Doherty, A Davidson and A Mackay

Feasibility of ultrasound-based identification of correct central venous access using two acoustic windows

Authors: G Zick, G Elke, D Schaedler, T Becher, L Balke and N Weiler

Intravenous oxygen administration in a rat model of hypoxia

Authors: E Damiani, A Donati and M Singer

Effect of a Lung Rest Strategy During Ecmo in a Porcine Acute Lung Injury Model

Authors: J Araos, P Cruces, P Tapia, L Alegria, P García, T Salomon, F Rodriguez, M Amthauer, G Castro, B Erranz, D Soto, P Carreño, T Medina, F Damiani, G Bugedo and A Bruhn

Modulation of inflammatory response related to severe peritonitis by polymyxin-B haemoperfusion

Authors: R Coudroy, J-C Lecron, DM Payen and R Robert

Circadian rhythm disruption exists in icu patients

Authors: K Kiss, I Földesi, B Köves, V Csernus and Z Molnár

Are extended and continuous infusions of time dependent antibiotics used in the management of sepsis in england today?

Authors: JA Dunning and JC Roberts

Inhalatory sedation in postoperative neurovascular surgery patients

Authors: R Badenes, A Belltall, V Chisbert, M De Fez, A Lozano, P Valls, I Fuentes, E Gracia and F Bilotta

Predictors of outcome and severity in adult filipino patients with febrile neutropenia

Authors: REM Villalobos, MG Yu, RP Berba and MMJ Juan-Bartolome

Evaluation of risk factors for mortality in hematological malignancy patients admitted to intensive care unit

Authors: I Ileri, R Coskun, K Gundogan, M Guven and M Sungur

Turning a fasthug [1] into low flat hugs could improve compliance with daily care bundles on the general intensive care unit: a preliminary audit

Authors: M Brooke and B Murthy

Are peripherally inserted central catheters in critical ill patients justified?

Authors: O Martínez González, D Ballesteros, C Martín Parra, M Chana, B López Matamala, MA Alonso Fernández, B Estébanez, J Luján and R Blancas

Improving error reporting at the ICU

Authors: EE Rouw and T van Galen