Articles
Page 5 of 36
-
Citation: Intensive Care Medicine Experimental 2021 9:58
-
Effects of therapeutic plasma exchange on the endothelial glycocalyx in septic shock
Disruption of the endothelial glycocalyx (eGC) is observed in septic patients and its injury is associated with multiple-organ failure and inferior outcomes. Besides this biomarker function, increased blood co...
Citation: Intensive Care Medicine Experimental 2021 9:57 -
Neutrophil gelatinase-associated lipocalin does not originate from the kidney during reperfusion in clinical renal transplantation
Acute Kidney Injury (AKI) is a common clinical complication. Plasma/serum neutrophil gelatinase-associated lipocalin (NGAL) has been proposed as a rapid marker of AKI. However, NGAL is not kidney-specific. It ...
Citation: Intensive Care Medicine Experimental 2021 9:56 -
Intracycle power and ventilation mode as potential contributors to ventilator-induced lung injury
High rates of inflation energy delivery coupled with transpulmonary tidal pressures of sufficient magnitude may augment the risk of damage to vulnerable, stress-focused units within a mechanically heterogeneou...
Citation: Intensive Care Medicine Experimental 2021 9:55 -
Data automated bag breathing unit for COVID-19 ventilator shortages
The COVID-19 pandemic has caused a global mechanical ventilator shortage for treatment of severe acute respiratory failure. Development of novel breathing devices has been proposed as a low cost, rapid solutio...
Citation: Intensive Care Medicine Experimental 2021 9:54 -
Plasma hyaluronan, hyaluronidase activity and endogenous hyaluronidase inhibition in sepsis: an experimental and clinical cohort study
Plasma hyaluronan concentrations are increased during sepsis but underlying mechanisms leading to high plasma hyaluronan concentration are poorly understood. In this study we evaluate the roles of plasma hyalu...
Citation: Intensive Care Medicine Experimental 2021 9:53 -
ESICM LIVES 2021: Part 2
Citation: Intensive Care Medicine Experimental 2021 9(Suppl 1):50 -
Computed tomographic assessment of lung aeration at different positive end-expiratory pressures in a porcine model of intra-abdominal hypertension and lung injury
Intra-abdominal hypertension (IAH) is common in critically ill patients and is associated with increased morbidity and mortality. High positive end-expiratory pressures (PEEP) can reverse lung volume and oxyge...
Citation: Intensive Care Medicine Experimental 2021 9:52 -
ESICM LIVES 2021: Part 1
Citation: Intensive Care Medicine Experimental 2021 9(Suppl 1):51 -
Evaluation of a simultaneous adsorption device for cytokines and platelet–neutrophil complexes in vitro and in a rabbit acute lung injury model
Platelet–neutrophil complexes (PNCs) readily migrate into tissues and induce tissue damage via cytokine or other pathogenic factors release. These actions are involved in onset and progression of acute respira...
Citation: Intensive Care Medicine Experimental 2021 9:49 -
A randomised controlled trial of succinylated gelatin (4%) fluid on urinary acute kidney injury biomarkers in cardiac surgical patients
Fluid resuscitation is frequently required for cardiac surgical patients admitted to the intensive care unit. The ideal fluid of choice in regard to efficacy and safety remains uncertain. Compared with crystal...
Citation: Intensive Care Medicine Experimental 2021 9:48 -
Novel method of transpulmonary pressure measurement with an air-filled esophageal catheter
There is a strong rationale for proposing transpulmonary pressure-guided protective ventilation in acute respiratory distress syndrome. The reference esophageal balloon catheter method requires complex in vivo...
Citation: Intensive Care Medicine Experimental 2021 9:47 -
Validation of a novel system to assess end-expiratory lung volume and alveolar recruitment in an ARDS model
Personalizing mechanical ventilation requires the development of reliable bedside monitoring techniques. The multiple-breaths nitrogen washin–washout (MBNW) technique is currently available to measure end-expi...
Citation: Intensive Care Medicine Experimental 2021 9:46 -
Killer immunoglobulin-like receptor 2DS5 is associated with recovery from coronavirus disease 2019
Despite numerous advances in the identification of risk factors for the development of severe coronavirus disease 2019 (COVID-19), factors that promote recovery from COVID-19 remain unknown. Natural killer (NK...
Citation: Intensive Care Medicine Experimental 2021 9:45 -
Progranulin signaling in sepsis, community-acquired bacterial pneumonia and COVID-19: a comparative, observational study
Progranulin is a widely expressed pleiotropic growth factor with a central regulatory effect during the early immune response in sepsis. Progranulin signaling has not been systematically studied and compared b...
Citation: Intensive Care Medicine Experimental 2021 9:43 -
Interstitial washdown and vascular albumin refill during fluid infusion: novel kinetic analysis from three clinical trials
Increased capillary filtration may paradoxically accelerate vascular refill of both fluid and albumin from the interstitial space, which is claimed to be edema-preventing. We characterized this proposed mechan...
Citation: Intensive Care Medicine Experimental 2021 9:44 -
Inflammatory markers assessment in an animal model of intracranial hypertension: a randomized trial
Intracranial hypertension (ICH) is a common final pathway of most neurosurgical pathologies and leads to poor prognosis if not detected and treated properly. Inflammatory markers have been assessed in clinical...
Citation: Intensive Care Medicine Experimental 2021 9:42 -
Complement factor D is linked to platelet activation in human and rodent sepsis
The complement factor D (CFD) exerts a regulatory role during infection. However, its physiological function in coagulopathy and its impact on the course of an infection remains unclear.
Citation: Intensive Care Medicine Experimental 2021 9:41 -
Rapid screening of critically ill patients for low plasma vitamin C concentrations using a point-of-care oxidation–reduction potential measurement
Hypovitaminosis C and vitamin C deficiency are common in critically ill patients and associated with organ dysfunction. Low vitamin C status often goes unnoticed because determination is challenging. The stati...
Citation: Intensive Care Medicine Experimental 2021 9:40 -
Flow-dependent regulation of endothelial Tie2 by GATA3 in vivo
Reduced endothelial Tie2 expression occurs in diverse experimental models of critical illness, and experimental Tie2 suppression is sufficient to increase spontaneous vascular permeability. Looking for a commo...
Citation: Intensive Care Medicine Experimental 2021 9:38 -
Effect of positive end-expiratory pressure on additional passive ventilation generated by CPR compressions in a porcine model
Compressions given during cardiopulmonary resuscitation generate small, ineffective passive ventilations through oscillating waves. Positive end-expiratory pressure increases the volume of these passive ventil...
Citation: Intensive Care Medicine Experimental 2021 9:37 -
Mortality of septic shock patients is associated with impaired mitochondrial oxidative coupling efficiency in lymphocytes: a prospective cohort study
Septic shock is a life-threatening condition that challenges immune cells to reprogram their mitochondrial metabolism towards to increase ATP synthesis for building an appropriate immunity. This could print me...
Citation: Intensive Care Medicine Experimental 2021 9:39 -
Plasma proenkephalin A 119–159 on intensive care unit admission is a predictor of organ failure and 30-day mortality
Proenkephalin A 119-159 (penKid) has been suggested as a marker of renal failure and poor outcome. We aimed to investigate the association of penKid on ICU admission with organ dysfunction and mortality in a m...
Citation: Intensive Care Medicine Experimental 2021 9:36 -
Pulmonary and intestinal microbiota dynamics during Gram-negative pneumonia-derived sepsis
The gut microbiome plays a protective role in the host defense against pneumonia. The composition of the lung microbiota has been shown to be predictive of clinical outcome in critically ill patients. However,...
Citation: Intensive Care Medicine Experimental 2021 9:35 -
Induced hypernatremia in patients with moderate-to-severe ARDS: a randomized controlled study
Induced hypernatremia and hyperosmolarity is protective in animal models of lung injury. We hypothesized that increasing and maintaining plasma sodium between 145 and 150 mmol/l in patients with moderate-to-se...
Citation: Intensive Care Medicine Experimental 2021 9:33 -
The Surviving Sepsis Campaign: research priorities for the administration, epidemiology, scoring and identification of sepsis
To identify priorities for administrative, epidemiologic and diagnostic research in sepsis.
Citation: Intensive Care Medicine Experimental 2021 9:34 -
Risk factors for adverse outcomes during mechanical ventilation of 1152 COVID-19 patients: a multicenter machine learning study with highly granular data from the Dutch Data Warehouse
The identification of risk factors for adverse outcomes and prolonged intensive care unit (ICU) stay in COVID-19 patients is essential for prognostication, determining treatment intensity, and resource allocat...
Citation: Intensive Care Medicine Experimental 2021 9:32 -
Preservation of renal endothelial integrity and reduction of renal edema by aprotinin does not preserve renal perfusion and function following experimental cardiopulmonary bypass
Acute kidney injury is a severe complication following cardiopulmonary bypass (CPB) and is associated with capillary leakage and microcirculatory perfusion disturbances. CPB-induced thrombin release results in...
Citation: Intensive Care Medicine Experimental 2021 9:30 -
A 29-mRNA host response test from blood accurately distinguishes bacterial and viral infections among emergency department patients
Whether or not to administer antibiotics is a common and challenging clinical decision in patients with suspected infections presenting to the emergency department (ED). We prospectively validate InSep, a 29-m...
Citation: Intensive Care Medicine Experimental 2021 9:31 -
Endothelial cell regulation of systemic haemodynamics and metabolism acts through the HIF transcription factors
The vascular endothelium has important endocrine and paracrine roles, particularly in the regulation of vascular tone and immune function, and it has been implicated in the pathophysiology of a range of cardio...
Citation: Intensive Care Medicine Experimental 2021 9:28 -
Norepinephrine and dobutamine improve cardiac index equally by supporting opposite sides of the heart in an experimental model of chronic pulmonary hypertension
Pulmonary hypertension is a significant risk factor in patients undergoing surgery. The combined effects of general anaesthesia and positive pressure ventilation can aggravate this condition and cause increase...
Citation: Intensive Care Medicine Experimental 2021 9:29 -
Dynamic compliance in flow-controlled ventilation
Citation: Intensive Care Medicine Experimental 2021 9:26 -
Continuous intra-gastral monitoring of intra-abdominal pressure in critically ill children: a validation study
In critically ill children, detection of intra-abdominal hypertension (IAH > 10 mmHg) and abdominal compartment syndrome (ACS = IAH + organ dysfunction) is paramount and usually monitored through intra-vesical...
Citation: Intensive Care Medicine Experimental 2021 9:24 -
The effect of targeting Tie2 on hemorrhagic shock-induced renal perfusion disturbances in rats
Hemorrhagic shock is associated with acute kidney injury and increased mortality. Targeting the endothelial angiopoietin/Tie2 system, which regulates endothelial permeability, previously reduced hemorrhagic sh...
Citation: Intensive Care Medicine Experimental 2021 9:23 -
Tissue adhesives for bacterial inhibition in extracorporeal membrane oxygenation cannulae
One of the most serious complications of extracorporeal membrane oxygenation (ECMO) therapy is ECMO cannulae infection, which can occur at quadruple the rate of central venous catheter infections, and signific...
Citation: Intensive Care Medicine Experimental 2021 9:25 -
Sepsis: deriving biological meaning and clinical applications from high-dimensional data
The pathophysiology of sepsis is multi-facetted and highly complex. As sepsis is a leading cause of global mortality that still lacks targeted therapies, increased understanding of its pathogenesis is vital fo...
Citation: Intensive Care Medicine Experimental 2021 9:27 -
Haptoglobin treatment prevents cell-free hemoglobin exacerbated mortality in experimental rat sepsis
Citation: Intensive Care Medicine Experimental 2021 9:22 -
End-tidal to arterial PCO2 ratio: a bedside meter of the overall gas exchanger performance
The physiological dead space is a strong indicator of severity and outcome of acute respiratory distress syndrome (ARDS). The “ideal” alveolar PCO2, in equilibrium with pulmonary capillary PCO2, is a central conc...
Citation: Intensive Care Medicine Experimental 2021 9:21 -
Treatment with senicapoc in a porcine model of acute respiratory distress syndrome
Senicapoc is a potent and selective blocker of KCa3.1, a calcium-activated potassium channel of intermediate conductance. In the present study, we investigated whether there is a beneficial effect of senicapoc...
Citation: Intensive Care Medicine Experimental 2021 9:20 -
Triiodothyronine prevents tissue hypoxia in experimental sepsis: potential therapeutic implications
Citation: Intensive Care Medicine Experimental 2021 9:17 -
Mechanical ventilation preserves diaphragm mitochondrial function in a rat sepsis model
To describe the effect of mechanical ventilation on diaphragm mitochondrial oxygen consumption, ATP production, reactive oxygen species (ROS) generation, and cytochrome c oxidase activity and content, and thei...
Citation: Intensive Care Medicine Experimental 2021 9:19 -
Point-of-care detection of lactate in cerebrospinal fluid
Measurements of cerebrospinal fluid (CSF) lactate can aid in detecting infections of the central nervous system and surrounding structures. Neurosurgical patients with temporary lumbar or ventricular CSF drain...
Citation: Intensive Care Medicine Experimental 2021 9:18 -
Evaluation of automated microvascular flow analysis software AVA 4: a validation study
Real-time automated analysis of videos of the microvasculature is an essential step in the development of research protocols and clinical algorithms that incorporate point-of-care microvascular analysis. In re...
Citation: Intensive Care Medicine Experimental 2021 9:15 -
A role for bronchial epithelial autotaxin in ventilator-induced lung injury
The pathophysiology of acute respiratory distress syndrome (ARDS) may eventually result in heterogeneous lung collapse and edema-flooded airways, predisposing the lung to progressive tissue damage known as ven...
Citation: Intensive Care Medicine Experimental 2021 9:12 -
Association of transcranial Doppler blood flow velocity slow waves with delayed cerebral ischemia in patients suffering from subarachnoid hemorrhage: a retrospective study
Cerebral vasospasm (VS) and delayed cerebral ischemia (DCI) constitute major complications following subarachnoid hemorrhage (SAH). A few studies have examined the relationship between different indices of cer...
Citation: Intensive Care Medicine Experimental 2021 9:11 -
National Preclinical Sepsis Platform: developing a framework for accelerating innovation in Canadian sepsis research
Despite decades of preclinical research, no experimentally derived therapies for sepsis have been successfully adopted into routine clinical practice. Factors that contribute to this crisis of translation incl...
Citation: Intensive Care Medicine Experimental 2021 9:14 -
Rapid changes in mucociliary transport in the tracheal epithelium caused by unconditioned room air or nebulized hypertonic saline and mannitol are not determined by frequency of beating cilia
Inspired air is heated and humidified in the nose before it reaches lower airways. This mechanism is bypassed during tracheostomy, directly exposing the airways to colder and drier air from the environment, kn...
Citation: Intensive Care Medicine Experimental 2021 9:8 -
Longitudinal multi-omics transition associated with fatality in critically ill COVID-19 patients
Critically ill COVID-19 patients have significantly increased risk of death. Although several circulating biomarkers are thought to be related to COVID-19 severity, few studies have focused on the characterist...
Citation: Intensive Care Medicine Experimental 2021 9:13 -
Is an EAA > 0.6 in severe COVID-19 patients synonymous with a toxic and pro-inflammatory endotoxin profile, and should we treat it?
Citation: Intensive Care Medicine Experimental 2021 9:16 -
The surviving sepsis campaign: fluid resuscitation and vasopressor therapy research priorities in adult patients
To expand upon the priorities of fluid resuscitation and vasopressor therapy research priorities identified by a group of experts assigned by the Society of Critical Care Medicine and the European Society of I...
Citation: Intensive Care Medicine Experimental 2021 9:10
Follow
- ISSN: 2197-425X (electronic)